メディシナルケミストリー分野  大学院修士課程 医歯理工学専攻  大学院博士課程 生命理工学系専攻

研究業績

原著論文 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005
著書 英文総説 和文総説
List of publications of Hirokazu Tamamura, Ph. D.(原著論文、英文総説 ※2004年以前を含む)

論文検索はこちらから

原著論文 2017

  1. Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura
    Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
    Bioconjugate Chem., in press (2017)
  2. Takuya Kobayakawa & Hirokazu Tamamura
    Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation.
    Tetrahedron, 73(30), 4464-4471 (2017)
  3. Kazuya Kobayashi, Takaaki Mizuguchi, Yasunao Hattori, Naho Ohara, Ryunosuke Ninomiya, Mika Iida, Honami Ooe, Yukako Yamazaki, Minami Takata, Hirokazu Tamamura & Kenichi Akaji
    Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor.
    J. Pept. Sci., 2017 Apr 4. doi: 10.1002/psc.3004 (2017)
  4. Hikaru Takano, Tetsuo Narumi, Wataru Nomura, and Hirokazu Tamamura
    Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
    J. Org. Chem., 82(5), 2739-2744 (2017)
  5. Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
    Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells.
    J. Pept. Sci. 2017 Jan 12. doi: 10.1002/psc.2946 (2017)
  6. Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Development of Anti-HIV Peptides Based on a Viral Capsid Protein.
    Biopolymers: Peptide Science, 2017 Jan;108(1). doi: 10.1002/bip.22920 (2017)

原著論文 2016

  1. Tomofumi Nakamura, Joseph R. Campbell, Amber R. Moore, Sachiko Otsu, Haruo Aikawa, Hirokazu Tamamura & Hiroaki Mitsuya
    Development and Validation of a Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization.
    J. Virol. Methods, 236, 196-206 (2016)
  2. Takuya Kobayakawa & Hirokazu Tamamura
    Efficient Synthesis of Xaa-Gly Type (Z)-Chloroalkene Dipeptide Isosteres via Organocuprate Mediated Reduction.
    Tetrahedron, 72(32), 4968-4971 (2016)
  3. Kei Toyama, Takaaki Mizuguchi, Wataru Nomura & Hirokazu Tamamura
    Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization.
    Bioorg. Med. Chem., 24(16), 3406-3412 (2016)
  4. Kenichi Hiramatsu & Hirokazu Tamamura
    A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst.
    Eur. J. Org. Chem., 2016(21), 3491-3494 (2016)
  5. Aisha Abduelmula, Ruijin Huang, Qin Pu, Hirokazu Tamamura, Gabriela Morosan-Puopolo & Beate Brand-Saberi
    SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite.
    Int. J. Dev. Biol., 60(1-2-3), 29-38 (2016)
  6. Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, and Tom W. Muir
    Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.
    Nat Commun., doi: 10.1038/ncomms10589 (2016)
  7. Kenichi Hiramatsu, Takashi Honjo, Vivek Rauniyar, and F. Dean Toste
    Enantioselective Synthesis of Fluoro−Dihydroquinazolones and −Benzooxazinones by Fluorination-Initiated Asymmetric Cyclization Reactions.
    ACS Catal., 6 (1), 151–154 (2016)
  8. Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.
    ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions, 11(8), 940-946 (2016)
  9. Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori; Yu Irahara; Yuko Yamada; Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.
    Bioorg. Med. Chem. Lett., 26(2), 397-400 (2016)

原著論文 2015

  1. Hikaru Takano, Tetsuo, Narumi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group.
    Org. Lett., 17(21), 5372-5375 (2015)
  2. Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
    Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.
    Bioorg. Med. Chem., 23(21), 6967-6973 (2015)
  3. Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
    Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.
    Org. Biomol. Chem., 13(32), 8734-8739 (2015)
  4. Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.
    Bioorg. Med. Chem., 23(15), 4423-4427 (2015)
  5. Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura
    An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides.
    Bioconjugate Chem., 26(6), 1080-1085 (2015)
  6. Takuya Kobayakawa, Tetsuo Narumi & Hirokazu Tamamura
    Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres.
    Org. Lett., 17(10), 2302-2305 (2015)

原著論文 2014

  1. Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura
    Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.
    Chem. Pharm. Bull.,62(10), 1019-1025 (2014)
  2. Maryna Masyuk, Aisha Abduelmula, Gabriela Morosan-Puopolo, Veysel Odemis, Rizwan Rehimi, Nargis Khalida, Faisal Yusuf, Jurgen Engele, Hirokazu Tamamura, Carsten Theiss & Beate Brand-Saberi
    Retrograde Migration of Pectoral Girdle Muscle Precursors Depends on CXCR4/SDF-1 Signaling.
    Histochem. Cell. Biol.,142(5), 473-488 (2014)
  3. Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.
    Tetrahedron, 70(34), 5122-5127 (2014)
  4. Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura
    Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups.
    Tetrahedron, 70(29), 4400-4404 (2014)
  5. Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.
    Org. Biomol. Chem., 12(23), 3821-3826 (2014)
  6. Tetsuo Narumi, Seiji Tsuzuki & Hirokazu Tamamura
    Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab Initio Calculations.
    Asian J. Org. Chem., 3(4), 497-503 (2014)
  7. Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura
    Isostere-Based Design of 8-Azacoumarin-Type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls.
    Org. Lett., 16(4), 1184-1187 (2014)

原著論文 2013

  1. Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura
    A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics.
    Bioorg. Med. Chem., 21(24), 7884-7889 (2013)
  2. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies.
    Bioorg. Med. Chem., 21(22), 6878-6885 (2013)
  3. Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi
    Generation of a Replication-competent Simian-human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic.
    J. Gen.Virol., 94(12), 2710-2716 (2013)
  4. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4.
    ChemMedChem, 8(10), 1668-1672 (2013)
  5. Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura
    Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.
    ACS Chem. Biol., 8(10), 2235-2244 (2013)
  6. Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors.
    Bioorg. Med. Chem., 21(15), 4452-4458 (2013)
  7. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.
    Bioorg. Med. Chem., 21(9), 2518-2526 (2013)
  8. Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Low Molecular Weight CXCR4 Ligands with Variable Spacers.
    ChemMedChem, 8(1), 118-124 (2013)

原著論文 2012

  1. Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura
    Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation.
    Org. Lett., 14, 4490-4493 (2012)
  2. Tetsuo Narumi, Tomohiro Tanaka, Chie Hashimoto, Wataru Nomura, Haruo Aikawa, Akira Sohma, Kyoko Itotani, Miyako Kawamata, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Pharmacophore-Based Small Molecule CXCR4 Ligands.
    Bioorg. Med. Chem. Lett., 22, 4169-4172 (2012)
  3. Chie Hashimoto, Wataru Nomura, Aki Ohya, Emiko Urano, Kosuke Miyauchi, Tetsuo Narumi, Haruo Aikawa, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
    Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines.
    Bioorg. Med. Chem., 20, 3287-3291 (2012)
  4. Wataru Nomura, Akemi Masuda, Kenji Ohba, Arisa Urabe, Nobutoshi Ito, Akihide Ryo, Naoki Yamamoto & Hirokazu Tamamura
    Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion. on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System.
    Biochemistry, 51, 1510-1517 (2012)
  5. Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun Komano, Naoki Yamamoto & Hirokazu Tamamura
    A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency.
    ChemMedChem, 7, 205-208 (2012)
  6. Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins.
    Bioorg. Med. Chem., 20, 1468-1474 (2012)

原著論文 2011

  1. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    Small Molecular CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 19, 6735-6742 (2011)
  2. Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii & Mitsuo Kaku
    The Increase in Surface CXCR4 Expression on Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury.
    Cell Mol. Immunol., 8, 305-314 (2011)
  3. Changshui Xu, Jianuo Liu, Lina Chen, Shangdong Liang, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    HIV-1 gp120 Enhances Outward Potassium Current via CXCR4 and cAMP-Dependent Protein Kinase a Signaling in Cultured Rat Microglia.
    Glia., 59, 997-1007 (2011)
  4. Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura
    Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore.
    Bioconjugate Chem., 22, 923-930 (2011)
  5. Tomohiro Tanaka, Tetsuo Narumi, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Azamacrocyclic-metal Complexes as CXCR4 Antagonists.
    ChemMedChem, 6, 834-839 (2011)
  6. Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino, Wataru Nomura & Hirokazu Tamamura
    Intense Blue Fluorescence in a Leucine Zipper Assembly.
    ChemBioChem, 12, 691-694 (2011)
  7. Nami Ohashi, Wataru Nomura, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura
    Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding.
    Bioconjugate Chem., 22, 82-87 (2011)
  8. Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura
    Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C.
    ChemBioChem, 12, 535-539 (2011)
  9. Tetsuo Narumi & Jeffrey W. Bode
    α,α-Dichloroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation OF α-Peptide α-Ketoacids.
    Heterocycles, 82, 1515-1525 (2011)

原著論文 2010

  1. Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi & Nobutaka Fujii
    Synthesis of Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres
    Org. Biomol. Chem., 8, 616-621 (2010)
  2. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda & Hirokazu Tamamura
    Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells
    J. Am. Chem. Soc.(Commun.),132, 15899-15901 (2010)
  3. Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist
    Bioorg. Med. Chem. Lett., 20, 5853-5858 (2010)
  4. Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano & Hirokazu Tamamura
    Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies.
    Bioorg. Med. Chem., 18, 6771-6775 (2010)
  5. Shintaro Suzuki, Emiko Urano, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Kasthuraiah Maddali, Yan Han, Makiko Hamatake, Kosuke Miyauchi, Yves Pommier, John A. Beutler, Wataru Sugiura, Hideyoshi Fuji, Tyuji Hoshino, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Jun A. Komano & Hirokazu Tamamura
    Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products.
    J. Med. Chem., 53(14), 5356-5360 (2010)
  6. Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura & Shuzo Matsushita
    Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds.
    J. Virol., 84(15), 7558-7568 (2010)
  7. Toru Aoki, Saki Shimizu, Emiko Urano, Yuko Futahashi, Makiko Hamatake, Hirokazu Tamamura, Kazuo Terashima, Tsutomu Murakami, Naoki Yamamoto & Jun Komano
    Improvement of Lentiviral Vector-mediated Gene Transduction by Genetic Engineering of the Structural Protein Pr55Gag.
    Gene Ther., 17(9), 1124-1133(2010)
  8. Roberta Melchionna, Anna Di Carlo, Roberta De Mori, Claudia Cappuzzello, Laura Barberi, Antonio Musar?, Chiara Cencioni, Nobutaka Fujii, Hirokazu Tamamura, Marco Crescenzi, Maurizio C. Capogrossi, Monica Napolitano & Antonia Germani
    Induction of Myogenic Differentiation by SDF-1 via CXCR4 and CXCR7 Receptors.
    Muscle Nerve., 41(6), 828-835 (2010)
  9. Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura
    Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins.
    Biopolymers: Peptide Science, 94, 843-852 (2010)
  10. Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies.
    Bioconjugate Chem., 21(4), 709-714 (2010)
  11. Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the Mechanism of HIV.
    Bioorg. Med. Chem. Lett., 20, 354-358 (2010)

原著論文 2009

  1. Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura
    Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells.
    Angew. Chem., Int. Ed., 48, 9164-9166 (2009)
  2. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: The Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids.
    Org. Biomol. Chem., 7, 3805-3809 (2009)
  3. Nami Ohashi, Wataru Nomura, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura
    Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding.
    J. Pept. Sci., 5(10), 642-646 (2009)
  4. Yuka Inaba, Nobuko Yoshimoto, Yuta Sakamaki, Makoto Nakabayashi, Teikichi Ikura, Hirokazu Tamamura, Nobutoshi Ito, Masato Shimizu & Keiko Yamamoto
    A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor.
    J. Med. Chem., 52(5), 1438-1449 (2009)
  5. Fuminori Mizukoshi, Kenji Baba, Yuko Goto-Koshino, Asuka Setoguchi-Mukai, Yasuhito Fujino, Koichi Ohno, Hirokazu Tamamura, Shinya Oishi, Nobutaka Fujii & Hajime Tsujimoto
    Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus.
    J. Vet. Med. Sci., 71(1), 121-124 (2009)

原著論文 2008

  1. Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore.
    Org. Biomol. Chem., 6, 4374-4377 (2008)
  2. Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto & Hirokazu Tamamura
    Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening.
    Bioconjugate Chem., 19, 1917-1920 (2008)
  3. Hirotomo Nakata, Seth M. Steinberg, Yasuhiro Koh, Kenji Maeda, Yoshikazu Takaoka, Hirokazu Tamamura, Nobutaka Fujii & Hiroaki Mitsuya
    Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs.
    Antimicrob. Agents Chemother., 52(6), 2111-2119 (2008)
  4. Wouter H. P., Driessen, Nobutaka Fujii, Hirokazu Tamamura & Sean M. Sullivan
    Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells.
    Mol. Ther., 16(3), 516-524 (2008)
  5. Alexander Kasiyanov, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    Modulation of Network-driven, GABA-mediated Giant Depolarizing Potentials by SDF-1 in Developing Hippocampus.
    Developmental Neuroscience, 30(4), 285-292 (2008)

原著論文 2007

  1. Kenji Kabashima, Noriko Shiraishi, Kazunari Sugita, Tomoko Mori, Ayako Onoue, Miwa Kobayashi, Jun-ichi Sakabe, Ryutaro Yoshiki, Hirokazu Tamamura, Nobutaka Fujii, Kayo Inaba & Yoshiki Tokura
    CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells.
    Am. J Pathol., 171(4), 1249-1257 (2007)
  2. Kenji Kabashima, Kazunari Sugita, Noriko Shiraishi, Hirokazu Tamamura, Nobutaka Fujii & Yoshiki Tokura
    CXCR4 Engagement Promotes Dendritic Cell Survival and Maturation.
    Biochem. Biophys. Res. Commun., 361, 1012-1016 (2007)
  3. Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii
    Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics.
    Tetrahedron, 63, 9243-9254 (2007)
  4. Yamina A. Berchiche, Ken Y. Chow, Bernard Lagane, Martin Leduc, Yann Percherancier, Nobutaka Fujii, Hirokazu Tamamura, Fran?oise Bachelerie & Nikolaus Heveker
    Direct Assessment of CXCR4 Mutant Conformations Reveals Complex link between Receptor Structure and Galphai Activation.
    J. Biol. Chem. (Commun.), 282, 5111 – 5115 (2007)
  5. Shiro Kubonishi, Tomoko Kikuchi, Shinya Yamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Toshimitsu Matsui, Mitsune Tanimoto & Yoshio Katayama
    Rapid Hematopoietic Progenitor Mobilization by Sulfated Colominic Acid.
    Biochem. Biophys. Res. Commun., 355 (4), 970-975 (2007)
  6. Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jerome Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Peiper & Nobutaka Fujii
    Structure-Activity Relationships of Cyclic Peptide-Based Chemokine Receptor CXCR4 Antagonists: Disclosing the Importance of Side-Chain and Backbone Functionalities.
    J. Med. Chem., 50(2), 192-198 (2007)

原著論文 2006

  1. Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, Stephen C. Peiper, Kazuo Kitaura, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated Anti-S(N)2 ‘ Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists.
    J. Org. Chem., 71 (10), 3942-3951 (2006)
  2. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Satoko Mizokami, Kenichi Hiramatsu, Zixuan Wang, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper & Nobutaka Fujii
    Development of a Linear Type of Low Molecular Weight CXCR4 Antagonists Based on T140 Analogs.
    Org. Biomol. Chem., 4, 2354-2357 (2006)
  3. Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi & Nobutaka Fujii
    Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure.
    J. Med. Chem., 49 (11), 3412-3415 (2006)
  4. Eline Menu, Kewal Asosingh, Stefano Indraccolo, Hendrik De Raeve, Ivan Van Riet, Els Van Valckenborgh, Isabelle Vande Broek, Nobutaka Fujii, Hirokazu Tamamura, Ben Van Camp & Karin Vanderkerken
    The Involvement of Stromal Derived Factor 1α in Homing and Progression of Multiple Myeloma in the 5TMM Model.
    Haematologica/the Hematology Journal, 91(5), 605-612 (2006)
  5. Hirofumi Hanaoka, Takahiro Mukai, Hirokazu Tamamura, Tomohiko Mori, Seigo Ishino, Kazuma Ogawa, Yasuhiko Iida, Ryuichiro Doi, Nobutaka Fujii & Hideo Saji
    Development of a In-111-Labeled Peptide Derivative Targeting a Chemokine Receptor, CXCR4, for Imaging Tumors.
    Nucl. Med. Biol., 33 (4), 489-494 (2006)
  6. Alexander Kasyanov, Hirokazu Tamamura, Nobutaka Fujii & Huangui Xiong
    HIV-1 gp120 Enhances Giant Depolarizing Potentials via Chemokine Receptor CXCR4 in Neonatal Rat Hippocampus.
    Eur. J. Neuroscience, 23, 1120-1128 (2006)
  7. Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii
    Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides.
    Tetrahedron, 62, 1416-1424 (2006)
  8. Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper & Nobutaka Fujii
    Design and Synthesis of Downsized Metastin (45-54) Analogs with Maintenance of High GPR54 Agonistic Activity.
    Bioorg. Med. Chem. Lett., 16(1), 134-137 (2006)

原著論文 2005

  1. Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Structure-activity Relationship Studies on CXCR4 Antagonists Having Cyclic Pentapeptide Scaffolds.
    Org. Biomol. Chem., 3, 4392-4394 (2005)
  2. Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum
    New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion.
    Eur. Urol., 48 (6), 1025-1030 (2005)
  3. Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Photolabile Protection for One-Pot Sequential Native Chemical Ligation.
    ChemBioChem, 6 (11), 1983-1986 (2005)
  4. Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent
    A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools.
    QSAR Comb. Sci., 24 (5), 620-630 (2005)
  5. Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2′ Reactions.
    Tetrahedron Lett., 46, 4183-4186 (2005)
  6. Meike Burger, Tanja Hartmann, Myriam Krome, Justyna Rawluk, Hirokazu Tamamura, Nobutaka Fujii, Thomas J. Kipps & Jan A. Burger
    Small Peptide Inhibitors of the CXCR4 Chemokine Receptor (CD184) Antagonize the Activation, Migration and Antiapoptotic Responses of CXCL12 in Chronic Lymphocytic Leukemia B Cells.
    Blood, 106 (5), 1824-1830 (2005)
  7. Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide-scaffolds.
    J. Med. Chem., 48, 3280-3289 (2005)
  8. Yann Percherancier, Yamina Berchiche, Isabelle Slight, Rudolf Volkmer-Engert, Hirokazu Tamamura, Nobutaka Fujii, Michel Bouvier & Nikolaus Heveker
    Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers.
    J. Biol. Chem., 280, 9895 – 9903 (2005)
  9. Andrew C. W. Zannettino, Amanda N. Farrugia, Angela Kortesidis, Jim Manavis, Luen B. To, Sally K. Martin, Peter Diamond, Hirokazu Tamamura, Tsvee Lapidot, Nobutaka Fujii & Stan Gronthos
    Elevated Serum Levels of SDF-1α are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients.
    Cancer Res., 65(5), 1700-1709 (2005)
  10. Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii & Masao Matsuoka
    Mutations Conferring Resistance to HIV-1 Fusion Inhibitors Are Restricted by gp41 and Rev Responsive Element Functions.
    J. Virol., 79, 764-770 (2005)
  11. Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.
    J. Med. Chem., 48, 380-391 (2005)
  12. Erich Piovan, Valeria Tosello, Stefano Indraccolo, Anna Cabrelle, Ilenia Baesso, Livio Trentin, Rita Zamarchi, Hirokazu Tamamura, Nobutaka Fujii, Gianpietro Semenzato, Luigi-Chieco Bianchi & Alberto Amadori
    Chemokine Receptor Expression in EBV-associated Lymphoproliferation in Hu/SCID Mice: Implications for CXCL12/CXCR4 Axis in Lymphoma Generation.
    Blood, 105, 931-939 (2005)

著書

  1. 野村 渉、田中智博、玉村啓和
    「HIV阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
    pp101-107. ペプチド医薬の最前線. (株)シーエムシー出版. 2012.
  2. 野村 渉、田中智博、相川春夫、玉村啓和
    「多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用」
    pp267-273.最新ペプチド合成技術とその創薬研究への応用.株式会社 メディカルドゥ.2012.
  3. 鳴海哲夫、Jeffrey W. Bode
    「α-ケト酸とヒドロキシアミンの化学選択的なライゲーション反応によるペプチド合成」
    pp68-75.最新ペプチド合成技術とその創薬研究への応用.株式会社 メディカルドゥ.2012.
  4. Masuda A, Nomura, W, Ohba K, Yamamoto N, Tamamura H.
    Studies for Optimum Design of Artificial Zinc Finger Recombinases by Evaluation of Effects of DNA Binding Affinity and Linker Components on Recombination Efficiency.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 130-131, 2011.
  5. Nomura W, Nakahara T, Hashimoto C, Ohba K , Narumi T, Yamamoto N, Tamamura T.
    Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 132-133, 2011.
  6. Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
    Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 134-135, 2011.
  7. Narumi T, Bode JW.
    α,α-Dicholoroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation of α-Peptide α-Ketoacids.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 178, 2011.
  8. Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
    Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 220, 2011.
  9. Hashimoto C, Narumi T, Nomura W, Yamamoto N, Tamamura H.
    ynthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 103, 2011.
  10. Nomura W, Ohashi N, Mori A, Narumi T, Tanaka T, Masuda A, Tsutsumi H, Tamamura H.
    Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 40, 2011.
  11. Tanaka T, Nomura W, Narumi T, Yoshimura K, Matsushita S, Murakami T, Komano J, Yamamoto N & Tamamura H
    From reverse to forward chemical genomics: Development of anti-HIV agent.
    Peptide Science 2009, Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka, 105-106, 2010.
  12. Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S & Fujii N
    Stereoselective Synthesis of Peptidomimetics Based on Acid-catalyzed Ring-opening of beta-Aziridinyl-alpha,beta-enoates.
    Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 149-150, 2009.
  13. Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N
    Development of Chemokine Receptor CXCR4 Antagonists Using Bio-mimetic Strategy.
    Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 145-146, 2009.
  14. Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T, Ohba K, Yamamoto N, Fujii N & Tamamura H
    Structure-activity relationship study of CXCR4 antagonists on the cyclic pentapeptide scaffold: Identification of new pharmacophore moieties.
    Peptide Science 2008, Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka, 273-276, 2009.
  15. Kobayashi K, Narumi T, Oishi S, Ohno H, Fujii N
    Diastereoselective synthesis of trifuluoromethylalkene dipeptide isosters based on nucleophilic trifluoromethylaion.
    Peptide Science 2008, Motoyoshi Nomizu(Eds.), The Japanese peptide Society, Osaka, 13-14, 2009.
  16. Ohashi N, Kato M, Matsumoto H, Tanaka T, Tsutsumi H, Masuno H, Nomura W, Yoshida K, Ikura T, Ito N & Tamamura H.
    Chemical Synthesis of a PKC C1b Domain by a Peptide Ligation Method and Expression of the Protein in E. coli and Their Application.
    4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
  17. Tamamura H, Komano A, Nakahara T, Ohashi1 N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto N.
    Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
    4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
  18. Tsutsumi H, Tanabe Y, Abe S, Mino T, Ohashi N, Tanaka T, Nomura W & Tamamura H.
    Development of Peptide Tools for Fluorescence Imaging of Proteins in Living Cells.
    Peptide Science 2007, Saburo Amimoto and Shin Ono,(Eds.), The Japanese peptide Society, Osaka, 95-96, 2008.
  19. Tamamura H, Komano A, Nakahara T, Ohashi N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto N.
    Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
    Peptide Science 2007, Saburo Amimoto and Shin Ono (Eds.), The Japanese peptide Society, Osaka, 335-336, 2008.
  20. Tamamura H, Tsutsumi H Masuno H, Ogawa T, Kenichi Hiramatsu K, Takanobu Araki T, Ueda S, Oishi S, Esaka A, Tanaka T, Ohashi N, Wang Z, Peiper SC, Trent JO, & Fujii N
    Synthesis and biological evaluation of CXCR4 antagonists as pharmaceutical agents,
    Peptides 2006, Rolka K. and. Rekowski P. and. Silberring J.,(Eds.), KENES, Geneva, 110-111, 2007.
  21. 濱崎啓太、堤浩
    ナノマテリアル・シクロデキストリン.
    pp129-148.シクロデキストリン学会編.米田出版.2005.

英文総説

  1. Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura
    Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines.
    Biopolymers: Peptide Science, 106(4), 622-628 (2016)
  2. Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura
    Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C.
    Biopolymers: Peptide Science, 100(6), 613-620 (2013)
  3. Chie Hashimoto, Tomohiro Tanaka, Tetsuo Narumi, Wataru Nomura & Hirokazu Tamamura
    The Success and Failures of HIV Drug Discovery.
    Expert Opin. Drug Discov., 6, 1067-1090 (2011)
  4. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii
    A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists.
    Expert Opin. Drug Discov., 3(10), 1155-1166 (2008)
  5. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura & Nobutaka Fujii
    Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing.
    Perspec. Medicin. Chem., 2, 1-9 (2008)
  6. Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Shinya Oishi & Nobutaka Fujii
    Therapeutic Potential of the Chemokine Receptor CXCR4 Antagonists as Multi-functional Agents.
    Biopolymers: Peptide Science, 88(2), 279-289 (2007)
  7. Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii
    Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis.
    Lett. Drug Design Discovery, 4, 20-26 (2007)
  8. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno & Nobutaka Fujii
    Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-scaffolds towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Curr. Med. Chem., 14 (1), 93-102 (2007)
  9. Hirokazu Tamamura, Hiroshi Tsutsumi & Nobutaka Fujii
    The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases.
    Mini-Rev. Med. Chem., 6 (9), 109-120 (2006)
  10. Hirokazu Tamamura & Hiroshi Tsutsumi
    Specific Probes for Chemokine Receptors.
    Chem. Biol., 13, 8-10 (2006)
  11. Hirokazu Tamamura & Nobutaka Fujii
    The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Expert Opin. Ther. Targets, 9 (6),1267-1282 (2005)
  12. Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
    Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides.
    Curr. HIV Res., 3 (4), 289 – 301 (2005)

和文総説

  1. 野村渉、玉村啓和
    「細胞内タンパク質を可視化するタグ—蛍光プローブシステム」
    「生化学」みにれびゅう(日本生化学会 東京)、89巻、1号、頁1-6、2017年
  2. 大橋南美、玉村啓和
    「ペプチドミメティックを活用した中分子創薬の研究」
    化学工業 特集「ペプチド化学の最前線(I)」 (化学工業社 川崎)、67巻 10号 頁9-17、2016年
  3. 玉村啓和
    「中分子創薬の可能性―ペプチドを創薬へと展開するー」
    現代化学(株式会社 東京化学同人)、6月号 543号 頁47-51、2016年
  4. 野村 渉、玉村啓和
    「多価型CXCR4リガンドの創製とがん細胞イメージング・検出」
    医学のあゆみ 第5土曜特集「GPCR研究の最前線2016」 (医歯薬出版株式会社 東京)、256巻 5号 頁430-437、2016年
  5. 野村 渉、玉村啓和
    「ターゲットタンパク質を特異的に認識するプローブ」
    「化学工業」特集「ペプチド化学の新潮流(I)」(化学工業社 川崎)、65(11)巻 頁8~14、2014年
  6. 玉村啓和
    「ペプチドミメティックスを活用した抗HIV剤の創製」
    「MEDCHEM NEWS」(日本薬学会 医薬化学部会)、24(1)巻 頁14~19、2014年
  7. 玉村啓和
    「ケミカルバイオロジーを基盤とした抗HIV剤の創製」
    「薬学雑誌」(日本薬学会)、131(1)巻 頁69~78、2012年
  8. 鳴海哲夫、玉村啓和
    「ペプチドミメティックによる創薬研究」
    「生化学」特集号「ペプチド科学と生化学の接点」(日本生化学会 東京)、第82巻6号 頁515-523、2010年
  9. 野村 渉、増田朱美、玉村啓和
    「エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製」
    「生化学」ミニレビュウ(日本生化学会 東京)、第82巻5号 頁393-397、2010年
  10. 橋本知恵、玉村啓和
    「タンパク質半合成技術を用いたプロテインスプライシング機構の律速段階を実証した」
    「ケミカルバイオロジー」(日本ケミカルバイオロジー学会 東京)、第3巻2号 頁15、2010年
  11. 玉村啓和
    「種々の作用点をターゲットとした抗HIV剤の創製」
    日本エイズ学会誌 (日本エイズ学会)、11巻、2号、頁100-101、2009年
  12. 玉村啓和
    「PK-Cを標的としたdiacylglycerolの環化誘導体の創製」
    ファルマシア 最前線(日本薬学会)、42巻、5号、頁431-435、2006年
  13. 玉村啓和
    「抗ウイルス薬・抗AIDS (HIV)薬」
    BIO Clinica(北隆館 東京)、21巻、3号、頁224-230、2006年
  14. 藤井信孝、大高章、玉村啓和
    「ケミカルプロテオミクスによる創薬基盤の革新―情報から制御へ」
    細胞工学 特集 飛躍するケミカルバイオロジー: 化学から生命現象を明らかに (秀潤社 東京)、24巻、11号、頁1181-1186、2005年
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