メディシナルケミストリー分野  大学院修士課程 医歯理工学専攻  大学院博士課程 生命理工学系専攻

野村 渉

略歴

野村 渉(ノムラ ワタル)
Wataru Nomura, Ph.D. 【CV

東京医科歯科大学 生体材料工学研究所
生体機能分子研究部門 メディシナルケミストリー分野
准教授
博士(薬学)(京都大学)

〒101-0062 東京都千代田区神田駿河台 2-3-10
Tel: (03)5280-8038
Fax: (03)5280-8039
e-mail: nomura.mr(ここに@をいれてください)tmd.ac.jp

 新学術領域研究「動的・多要素な生体分子ネットワークを理解するための合成生物学の基盤構築(合成生物学)」(H24.4-H28.3)に参加しています。

 新学術領域研究「共鳴誘導で革新するバイオイメージング(レゾナンスバイオ)」に参加しています。

生年月日

1977年5月10日

学歴・職歴・資格

2000年3月 京都大学薬学部卒業(杉浦幸雄教授)
2002年3月 京都大学大学院薬学研究科修士課程修了(杉浦幸雄教授)
2005年3月 京都大学大学院薬学研究科博士後期課程修了(杉浦幸雄教授)
2005年4月 スクリプス研究所分子生物学科 博士研究員(Carlos F. Barbas, Ⅲ教授)
2007年8月 東京医科歯科大学生体材料工学研究所 助教(玉村啓和教授)
2012年1月 東京医科歯科大学生体材料工学研究所 講師(玉村啓和教授)
2013年4月 東京医科歯科大学生体材料工学研究所 准教授(玉村啓和教授)
この間、
2002年4月~2005年3月 日本学術振興会特別研究員(DC1)

研究分野

生物化学

所属学会

日本薬学会、日本化学会、日本ケミカルバイオロジー学会、日本ペプチド学会、アメリカ化学会

受賞歴

  1. 2013年 平成25年度日本ペプチド学会奨励賞受賞
  2. 2010年 薬学会ハイライト  日本薬学会第130年会
  3. 2009年 第3回日本エピジェネティクス研究会年会長賞

Selected publications of Wataru Nomura, Ph. D.

  1. Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura
    Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
    Bioconjugate Chem., in press (2017)
  2. Hikaru Takano, Tetsuo Narumi, Wataru Nomura, and Hirokazu Tamamura
    Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
    J. Org. Chem., 82(5), 2739-2744 (2017)
  3. Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
    Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells.
    J. Pept. Sci. 2017 Jan 12. doi: 10.1002/psc.2946 (2017)
  4. Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Development of Anti-HIV Peptides Based on a Viral Capsid Protein.
    Biopolymers: Peptide Science, 2017 Jan;108(1). doi: 10.1002/bip.22920 (2017)
  5. Kei Toyama, Takaaki Mizuguchi, Wataru Nomura & Hirokazu Tamamura
    Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization.
    Bioorg. Med. Chem., 24(16), 3406-3412 (2016)
  6. Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura
    Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines.
    Biopolymers: Peptide Science, 106(4), 622-628 (2016)
  7. Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.
    ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions, 11(8), 940-946 (2016)
  8. Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.
    Bioorg. Med. Chem. Lett., 26(2), 397-400 (2016)
  9. Hikaru Takano, Tetsuo, Narumi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group.
    Org. Lett., 17(21), 5372-5375 (2015)
  10. Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
    Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.
    Bioorg. Med. Chem., 23(21), 6967-6973 (2015)
  11. Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
    Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.
    Org. Biomol. Chem., 13(32), 8734-8739 (2015)
  12. Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.
    Bioorg. Med. Chem., 23(15), 4423-4427 (2015)
  13. Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura
    An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides.
    Bioconjugate Chem., 26(6), 1080-1085 (2015)
  14. Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura
    Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.
    Chem. Pharm. Bull.,62(10), 1019-1025 (2014)
  15. Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.
    Tetrahedron, 70(34), 5122-5127 (2014)
  16. Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura
    Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups.
    Tetrahedron, 70(29), 4400-4404 (2014)
  17. Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.
    Org. Biomol. Chem., 12(23), 3821-3826 (2014)
  18. Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura
    Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C.
    Biopolymers: Peptide Science, 100(6), 613-620 (2013)
  19. Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura
    A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics.
    Bioorg. Med. Chem., 21(24), 7884-7889 (2013)
  20. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies.
    Bioorg. Med. Chem., 21(22), 6878-6885 (2013)
  21. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4.
    ChemMedChem, 8(10), 1668-1672 (2013)
  22. Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura
    Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.
    ACS Chem. Biol., 8(10), 2235-2244 (2013)
  23. Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors.
    Bioorg. Med. Chem., 21(15), 4452-4458 (2013)
  24. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.
    Bioorg. Med. Chem., 21(9), 2518-2526 (2013)
  25. Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Low Molecular Weight CXCR4 Ligands with Variable Spacers.
    ChemMedChem, 8(1), 118-124 (2013)
  26. Wataru Nomura, Akemi Masuda, Kenji Ohba, Arisa Urabe, Nobutoshi Ito, Akihide Ryo, Naoki Yamamoto & Hirokazu Tamamura
    Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System
    Biochemistry, 51(7), 1510-1517 (2012)
  27. Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
    Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency
    ChemMedChem, 7, 205-208 (2012)
  28. Chie Hashimoto, Wataru Nomura, Aki Ohya, Emiko Urano, Kosuke Miyauchi, Tetsuo Narumi, Haruo Aikawa, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
    Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines
    Bioorg. Med. Chem., 20, 3287-3291 (2012)
  29. Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura
    Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore
    Bioconjugate Chem., 22, 923-930(2011)
  30. Nami Ohashi, Wataru Nomura, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura
    Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding
    Bioconjugate Chem., 22, 82-87(2011)
  31. Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura
    Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C
    ChemBioChem,12, 535-539 (2011)
  32. Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura
    Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins
    Biopolymers: Peptide Science, 94, 843-852(2010)
  33. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda & Hirokazu Tamamura
    Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of the Dimerization State in Cells
    J. Am. Chem. Soc., 132 (45), 15899-15901(2010)
  34. Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies
    Bioconjugate Chem., 21(4), 709-714 (2010)
  35. Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura
    Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells
    Angew. Chem., Int. Ed., 48, 9164-9166 (2009)
  36. Nami Ohashi, Wataru Nomura, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura
    Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding
    J. Pept. Sci., 5(10), 642-646 (2009)
  37. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii, & Hirokazu Tamamura
    Structure-Activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: the Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acid
    Org. Biomol. Chem., 7, 3805-3809 (2009)
  38. Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto & Hirokazu Tamamura
    Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening
    Bioconjugate Chem., 19, 1917-1920 (2008)
  39. Wataru Nomura & Carlos F. Barbas, III
    In Vivo Site-Specific DNA Methylation with a Designed Sequence-Enabled DNA Methylase
    J. Am. Chem. Soc., 29; 8676-8677 (2007)
  40. Wataru Nomura, Makoto Nagaoka, Yasuhisa Shiraishi & Yukio Sugiura
    Influence of TFIIIA-Type Linker at the N- or C-Terminal of Nine-Zinc Finger Protein on DNA Binding Site
    Biochem. Biophys. Res. Commun., 300, 87-92 (2003)
  41. Wataru Nomura & Yukio Sugiura
    Effects of Length and Position of an Extended Linker on Sequence-Selective DNA Recognition of Zinc Finger Peptides
    Biochemistry, 42, 14805-14813 (2003)
PAGETOP
〒101-0062 東京都千代田区神田駿河台2-3-10 東京医科歯科大学 生体材料工学研究所6階
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