メディシナルケミストリー分野　　大学院修士課程　医歯理工保健学専攻　　大学院博士課程　生命理工医療科学専攻

研究業績

原著論文 2024 2023 2022 2021  2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005
著書 英文総説  和文総説 オピニオン 総説の編集

List of publications of Hirokazu Tamamura, Ph. D.（原著論文、英文総説　※2004年以前を含む)

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原著論文2024

  1. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Peter Bolah, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Effect of two-photon excitation to 8-azacoumarin derivatives as photolabile protecting groups
    Chem. Pharm. Bull., 72 (3), 311-312 (2024). doi.org/10.1248/cpb.c24-00013　(Featured Article)

原著論文2023

  1. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Sayaka Boku, Masaki Kurakami, Masayuki Fujino, Takahiro Ishii, Yutaro Miura, Soshi Nishimura, Kouki Shinohara, Kenichi Yamamoto, Peter Bolah, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
    Development of small-molecule anti-HIV-1 agents targeting HIV-1 capsid proteins.
    Chem. Pharm. Bull., 72 (1), 41-47 (2024). doi.org/10.1248/cpb.c23-00618
  2. Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
    Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement.
    Chem. Pharm. Bull., 71, 879-886 (2023). doi.org/10.1248/cpb.c23-00562
  3. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
    Structure–Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moietie.
    J. Med. Chem., 66, 13516-13529 (2023). doi.org/10.1021/acs.jmedchem.3c00777 (TMDU press release)
  4. Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka & Hirokazu Tamamura
    Development of Anti-HBV Agents Targeting HBV Capsid Proteins.
    RSC. Med. Chem., 14, 1973-1980 (2023). doi.org/10.1039/d3md00258f (TMDU press release) (Front Cover)
  5. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda & Hirokazu Tamamura
    Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity.
    Eur. J. Med. Chem., 256, 115449(article number) published: Aug 05 (2023). doi: 10.1016/j.ejmech.2023.115449 (TMDU press release, TMDU Int’l press release)
  6. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki & Hirokazu Tamamura
    Dimerized Fusion Inhibitor Peptides Targeting the HR1-HR2 Interaction of SARS-CoV-2.
    RSC Adv., 13, 8779-8793 (2023). doi: 10.1039/d2ra07356k
  7. Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura & Hiroaki Mitsuya
    Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature Commun., 14, 1076(article number) (2023). doi: 10.1038/s41467-023-36729-0
  8. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Yuki Kishihara, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
    Low-molecular-weight Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins.
    RSC Adv., 13, 2156-2167 (2023). doi: 10.1039/d2ra06837k
  9. Kanako Matsuura, Mizuki Yamaura, Hiromi Sakawaki, Ai Himeno, Yalcin Pisil, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Shuzo Matsushita & Tomoyuki Miura
    Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C.
    Virology, 578, 171-179 (2023). doi.org/10.1016/j.virol.2022.12.004

原著論文2022

  1. Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda & Hiroaki Takeuchi
    4-Phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells.
    Biochem. Biophys. Res. Commun., 641, 139-147 (2023). doi.org/10.1016/j.bbrc.2022.12.024
  2. Kaho Matsumoto, Takeo Kuwata, William Tolbert, Jonathan Richard, Shilei Ding, Jérémie Prévost, Shokichi Takahama, George Judicate, Takamasa Ueno, Hirotomo Nakata, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Amos Smith III, Marzena Pazgier, Andrés Finzi & Shuzo Matsushita
    Characterization of a novel CD4 mimetic compound YIR-821 against HIV-1 clinical isolates.
    J. Virol., 97 (1), e01638-22 (2023). doi.org/10.1128/jvi.01638-22
  3. Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors.
    Bioorg. Med. Chem., 76, 117083(article number) (2022). doi.org: 10.1016/j.bmc.2022.117083
  4. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya & Hirokazu Tamamura
    Potent and Biostable Inhibitors of the Main Protease of SARS-CoV-2.
    iScience, 25 (11), 105365(article number) published: Nov 01 (2022). doi.org/10.1016/j.isci.2022.105365 (TMDU press release, TMDU Int’l press release)
  5. Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinovd & Terrence R. Burke, Jr.
    Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.
    RSC Chemical Biology, 3 (9), 1111-1120 (2022). doi: 10.1039/D2CB00153E (Back Cover picture)

  6. Kohei Tsuji, Takuya Kobayakawa, Kiju Konno, Ami Masuda, Kohei Takahashi, Nami Ohashi, Kazuhisa Yoshimura, Takeo Kuwata, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Exploratory Studies on Soluble Small Molecule CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 56, 116616(article number) (2022). doi.org: 10.1016/j.bmc.2022.116616 (Cover picture)

原著論文2021

  1. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, & Hirokazu Tamamura
    Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-Methoxynaphthalene-labeled 1,2-Diacylglycerol-lactones
    Org. Biomol. Chem., 19(38), 8264-8271 (2021). doi: 10.1039/d1ob00814e (Inside Front Cover)
  2. Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji & Hirokazu Tamamura
    Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application
    J. Org. Chem., 86(7), 5091-5101 (2021). doi.org: 10.1021/acs.joc.0c03019 (TMDU & TOYAKU press release)
  3. Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda
    A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells with a Combination of Latency-reversing Agents Containing DAG-lactone PKC Activators
    Frontiers in Microbiology, 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021.
  4. Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura & Shiroh Futaki
    Discovery of a Macropinocytosis-inducing Peptide Potentiated by Medium-mediated Intramolecular Disulfide Formation
    Angew. Chem., Int. Ed., 60(21), 11928-11936 (2021). doi: 10.1002/anie.202016754
  5. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
    Small-molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins.
    Biomolecules, 11, 208 (2021). https://doi.org/10.3390/biom11020208 (TMDU & AMED press release)
  6. Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
    Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors.
    J. Med. Chem.,64(3), 1481-1496 (2021). doi.org: 10.1021/acs.jmedchem.0c01153 (Supplementary Journal Cover, TMDU & AMED press release)
  7. Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Kofi Baffour-Awuah Owusu, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Potent Leads Based on CA-19L, an Anti-HIV Active HIV-1 Capsid Fragment.
    Bioorg. Med. Chem., 30, 115923 (2021). doi.org: 10.1016/j.bmc.2020.115923 (Cover picture)

原著論文2020

  1. Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
    A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Shows Improved Genome Editing Accuracy.
    Communications Biology, 3, 1-10 (2020). doi: 10.1038/s42003-020-01340-2　(TMDU & Hiroshima Univ. press release)
  2.  Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura
    Bivalent HIV-1 Fusion Inhibitors Based on Peptidomimetics.
    Bioorg. Med. Chem., 28(24), 115812 (2020). doi.org: 10.1016/j.bmc.2020.115812
  3. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications.
    Org. Biomol. Chem., 18, 4217-4223 (2020). doi: 10.1039/d0ob00807a
  4.  Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Exploratory Studies on CA-15L, an Anti-HIV Active HIV-1 Capsid Fragment.
    Bioorg. Med. Chem., 28(11), 115488 (2020). doi.org: 10.1016/j.bmc.2020.115488
  5. Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
    TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases.
    Biochemistry, 59(2), 197-204 (2020). doi: 10.1021/acs.biochem.9b00798

原著論文　2019

  1. Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura & Shuzo Matsushita
    Synergistic Inhibition of Cell-to-cell HIV-1 Infection by Combinations of Single Chain Variable Fragments and Fusion Inhibitors.
    Biochem Biophys Rep., 20, (2019). Sep 21; doi: 10.1016/j.bbrep.2019.100687. eCollection 2019 Dec.
  2. Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors.
    ChemBioChem: Special Issue dedicated to the 10th IPS in Kyoto, 20(16) 2101-2108 (2019). doi: 10.1002/cbic.201900187 (Cover picture)
  3. Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
    Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands.
    Bioconjugate Chem., 30(5), 1442-1450 (2019). doi: 10.1021/acs.bioconjchem.9b00182
  4. Maxwell M. Sakyiamah, Takuya Kobayakawa, Masayuki Fujino, Makoto Konno, Tetsuo Narumi, Tomohiro Tanaka, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Design, Synthesis and Biological Evaluation of Low Molecular Weight CXCR4 Ligands.
    Bioorg. Med. Chem.: Special Issue entitled “Strategic Basic Molecular Medicinal Chemistry,” 27(6), 1130-1138 (2019). doi.org/10.1016/j.bmc.2019.02.013
  5. Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada & Hirokazu Tamamura
    Soluble-type Small-molecule CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem. Lett., 29(5), 719-723 (2019). doi.org/10.1016/j.bmcl.2019.01.011
  6. Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-ichiro Hattori, Wataru Nomura, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya & Kenji Maeda
    Benzolactam-Related Compounds Promote Apoptosis Via Protein Kinase C-Induced HIV Latency Reversal.
    J. Biol. Chem., 294(1), 116-129 (2019). doi: 10.1074/jbc.RA118.005798.
  7. Akinobu Z. Suzuki, Ryota Sekine, Shiori Takeda, Ryosuke Aikawa, Yukiko Shiraishi, Tomomi Hamaguchi, Hiroyuki Okuno, Hirokazu Tamamura & Toshiaki Furuta
    A Clickable Caging Group as a New Platform for Modular Caged Compounds with Improved Photochemical Properties.
    Chem. Comm., 55, 451-454 (2019). doi: 10.1039/c8cc07981a

原著論文　2018

  1. Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa & Hirokazu Tamamura
    Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors.
    Biochemistry, 57(45), 6452-6459 (2018). doi: 10.1021/acs.biochem.8b00741
  2. Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Flexibility of Small Molecular CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 26(21), 5664-5671 (2018). doi.org: 10.1016/j.bmc.2018.10.011
  3. Kei Toyama, Takuya Kobayakawa, Wataru Nomura & Hirokazu Tamamura
    Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
    Chem. Pharm. Bull., 66(11), 1083-1089 (2018).
  4. Kei Toyama, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
    Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
    Bioconjugate Chem., 29(6), 2050-2057 (2018). doi: 10.1021/acs.bioconjchem.8b00250
  5. Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu & Hirokazu Tamamura
    Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.
    ACS Med. Chem. Lett., 9(1), 6-10 (2018). doi: 10.1021/acsmedchemlett.7b00234

原著論文　2017

  1. Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura
    Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
    Bioconjugate Chem., 28(8), 2135-2144 (2017)
  2. Takuya Kobayakawa & Hirokazu Tamamura
    Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation.
    Tetrahedron, 73(30), 4464-4471 (2017)
  3. Kazuya Kobayashi, Takaaki Mizuguchi, Yasunao Hattori, Naho Ohara, Ryunosuke Ninomiya, Mika Iida, Honami Ooe, Yukako Yamazaki, Minami Takata, Hirokazu Tamamura & Kenichi Akaji
    Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor.
    J. Pept. Sci., 23(7-8), 581-586 (2017)
  4. Hikaru Takano, Tetsuo Narumi, Wataru Nomura, and Hirokazu Tamamura
    Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
    J. Org. Chem., 82(5), 2739-2744 (2017)
  5. Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
    Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells.
    J. Pept. Sci., 23(7-8), 574-580 (2017)
  6. Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Development of Anti-HIV Peptides Based on a Viral Capsid Protein.
    Biopolymers: Peptide Science, 2017 Jan;108(1). doi: 10.1002/bip.22920 (2017)

原著論文　2016

  1. Tomofumi Nakamura, Joseph R. Campbell, Amber R. Moore, Sachiko Otsu, Haruo Aikawa, Hirokazu Tamamura & Hiroaki Mitsuya
    Development and Validation of a Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization.
    J. Virol. Methods, 236, 196-206 (2016)
  2. Takuya Kobayakawa & Hirokazu Tamamura
    Efficient Synthesis of Xaa-Gly Type (Z)-Chloroalkene Dipeptide Isosteres via Organocuprate Mediated Reduction.
    Tetrahedron, 72(32), 4968-4971 (2016)
  3. Kei Toyama, Takaaki Mizuguchi, Wataru Nomura & Hirokazu Tamamura
    Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization.
    Bioorg. Med. Chem., 24(16), 3406-3412 (2016)
  4. Kenichi Hiramatsu & Hirokazu Tamamura
    A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst.
    Eur. J. Org. Chem., 2016(21), 3491-3494 (2016)
  5. Aisha Abduelmula, Ruijin Huang, Qin Pu, Hirokazu Tamamura, Gabriela Morosan-Puopolo & Beate Brand-Saberi
    SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite.
    Int. J. Dev. Biol., 60(1-2-3), 29-38 (2016)
  6. Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, and Tom W. Muir
    Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.
    Nat Commun., doi: 10.1038/ncomms10589 (2016)
  7. Kenichi Hiramatsu, Takashi Honjo, Vivek Rauniyar, and F. Dean Toste
    Enantioselective Synthesis of Fluoro−Dihydroquinazolones and −Benzooxazinones by Fluorination-Initiated Asymmetric Cyclization Reactions.
    ACS Catal., 6 (1), 151–154 (2016)
  8. Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura　& Hirokazu Tamamura
    Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.
    ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions, 11(8), 940-946 (2016)
  9. Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori; Yu Irahara; Yuko Yamada; Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.
    Bioorg. Med. Chem. Lett., 26(2), 397-400 (2016)

原著論文　2015

  1. Hikaru Takano, Tetsuo, Narumi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group.
    Org. Lett., 17(21), 5372-5375 (2015)
  2. Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
    Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.
    Bioorg. Med. Chem., 23(21), 6967-6973 (2015)
  3. Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
    Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.
    Org. Biomol. Chem., 13(32), 8734-8739 (2015)
  4. Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.
    Bioorg. Med. Chem., 23(15), 4423-4427 (2015)
  5. Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura
    An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides.
    Bioconjugate Chem., 26(6), 1080-1085 (2015)
  6. Takuya Kobayakawa, Tetsuo Narumi & Hirokazu Tamamura
    Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres.
    Org. Lett., 17(10), 2302-2305 (2015)

原著論文　2014

  1. Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura
    Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.
    Chem. Pharm. Bull.,62(10), 1019-1025 (2014)
  2. Maryna Masyuk, Aisha Abduelmula, Gabriela Morosan-Puopolo, Veysel Odemis, Rizwan Rehimi, Nargis Khalida, Faisal Yusuf, Jurgen Engele, Hirokazu Tamamura, Carsten Theiss & Beate Brand-Saberi
    Retrograde Migration of Pectoral Girdle Muscle Precursors Depends on CXCR4/SDF-1 Signaling.
    Histochem. Cell. Biol.,142(5), 473-488 (2014)
  3. Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.
    Tetrahedron, 70(34), 5122-5127 (2014)
  4. Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura
    Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups.
    Tetrahedron, 70(29), 4400-4404 (2014)
  5. Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.
    Org. Biomol. Chem., 12(23), 3821-3826 (2014)
  6. Tetsuo Narumi, Seiji Tsuzuki & Hirokazu Tamamura
    Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab Initio Calculations.
    Asian J. Org. Chem., 3(4), 497-503 (2014)
  7. Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura
    Isostere-Based Design of 8-Azacoumarin-Type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls.
    Org. Lett., 16(4), 1184-1187 (2014)

原著論文　2013

  1. Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura
    A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics.
    Bioorg. Med. Chem., 21(24), 7884-7889 (2013)
  2. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies.
    Bioorg. Med. Chem., 21(22), 6878-6885 (2013)
  3. Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi
    Generation of a Replication-competent Simian-human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic.
    J. Gen.Virol., 94(12), 2710-2716 (2013)
  4. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4.
    ChemMedChem, 8(10), 1668-1672 (2013)
  5. Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura
    Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.
    ACS Chem. Biol., 8(10), 2235-2244 (2013)
  6. Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors.
    Bioorg. Med. Chem., 21(15), 4452-4458 (2013)
  7. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.
    Bioorg. Med. Chem., 21(9), 2518-2526 (2013)
  8. Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Low Molecular Weight CXCR4 Ligands with Variable Spacers.
    ChemMedChem, 8(1), 118-124 (2013)

原著論文　2012

  1. Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura
    Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation.
    Org. Lett., 14, 4490-4493 (2012)
  2. Tetsuo Narumi, Tomohiro Tanaka, Chie Hashimoto, Wataru Nomura, Haruo Aikawa, Akira Sohma, Kyoko Itotani, Miyako Kawamata, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Pharmacophore-Based Small Molecule CXCR4 Ligands.
    Bioorg. Med. Chem. Lett., 22, 4169-4172 (2012)
  3. Chie Hashimoto, Wataru Nomura, Aki Ohya, Emiko Urano, Kosuke Miyauchi, Tetsuo Narumi, Haruo Aikawa, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
    Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines.
    Bioorg. Med. Chem.,　20, 3287-3291 (2012)
  4. Wataru Nomura, Akemi Masuda, Kenji Ohba, Arisa Urabe, Nobutoshi Ito, Akihide Ryo, Naoki Yamamoto & Hirokazu Tamamura
    Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion. on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined　by a Facile Fluorescent System.
    Biochemistry, 51, 1510-1517 (2012)
  5. Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun Komano, Naoki Yamamoto & Hirokazu Tamamura
    A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency.
    ChemMedChem, 7, 205-208 (2012)
  6. Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins.
    Bioorg. Med. Chem., 20, 1468-1474 (2012)

原著論文　2011

  1. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    Small Molecular CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 19, 6735-6742 (2011)
  2. Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii & Mitsuo Kaku
    The Increase in Surface CXCR4 Expression on　Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury.
    Cell Mol. Immunol., 8, 305-314 (2011)
  3. Changshui Xu, Jianuo Liu, Lina Chen, Shangdong Liang, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    HIV-1 gp120 Enhances Outward Potassium Current via CXCR4 and cAMP-Dependent Protein Kinase a Signaling in Cultured Rat Microglia.
    Glia., 59, 997-1007 (2011)
  4. Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura
    Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore.
    Bioconjugate Chem., 22, 923-930 (2011)
  5. Tomohiro Tanaka, Tetsuo Narumi, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Azamacrocyclic-metal Complexes as CXCR4 Antagonists.
    ChemMedChem, 6, 834-839 (2011)
  6. Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino, Wataru Nomura & Hirokazu Tamamura
    Intense Blue Fluorescence in a Leucine Zipper Assembly.
    ChemBioChem, 12, 691-694 (2011)
  7. Nami Ohashi, Wataru Nomura, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura
    Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding.
    Bioconjugate Chem., 22, 82-87 (2011)
  8. Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura
    Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C.
    ChemBioChem, 12, 535-539 (2011)
  9. Tetsuo Narumi & Jeffrey W. Bode
    α,α-Dichloroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation OF α-Peptide α-Ketoacids.
    Heterocycles, 82, 1515-1525 (2011)

原著論文　2010

  1. Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi & Nobutaka Fujii
    Synthesis of Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres
    Org. Biomol. Chem., 8, 616-621 (2010)
  2. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda & Hirokazu Tamamura
    Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells
    J. Am. Chem. Soc.(Commun.),132, 15899-15901 (2010)
  3. Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist
    Bioorg. Med. Chem. Lett., 20, 5853-5858 (2010)
  4. Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano & Hirokazu Tamamura
    Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies.
    Bioorg. Med. Chem., 18, 6771-6775 (2010)
  5. Shintaro Suzuki, Emiko Urano, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Kasthuraiah Maddali, Yan Han, Makiko Hamatake, Kosuke Miyauchi, Yves Pommier, John A. Beutler, Wataru Sugiura, Hideyoshi Fuji, Tyuji Hoshino, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Jun A. Komano & Hirokazu Tamamura
    Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products.
    J. Med. Chem., 53(14), 5356-5360 (2010)
  6. Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura & Shuzo Matsushita
    Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds.
    J. Virol., 84(15), 7558-7568 (2010)
  7. Toru Aoki, Saki Shimizu, Emiko Urano, Yuko Futahashi, Makiko Hamatake, Hirokazu Tamamura, Kazuo Terashima, Tsutomu Murakami, Naoki Yamamoto & Jun Komano
    Improvement of Lentiviral Vector-mediated Gene Transduction by Genetic Engineering of the Structural Protein Pr55Gag.
    Gene Ther., 17(9), 1124-1133(2010)
  8. Roberta Melchionna, Anna Di Carlo, Roberta De Mori, Claudia Cappuzzello, Laura Barberi, Antonio Musar?, Chiara Cencioni, Nobutaka Fujii, Hirokazu Tamamura, Marco Crescenzi, Maurizio C. Capogrossi, Monica Napolitano & Antonia Germani
    Induction of Myogenic Differentiation by SDF-1 via CXCR4 and CXCR7 Receptors.
    Muscle Nerve., 41(6), 828-835 (2010)
  9. Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura
    Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins.
    Biopolymers: Peptide Science, 94, 843-852 (2010)
  10. Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies.
    Bioconjugate Chem., 21(4), 709-714 (2010)
  11. Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the Mechanism of HIV.
    Bioorg. Med. Chem. Lett., 20, 354-358 (2010)

原著論文　2009

  1. Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura
    Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells.
    Angew. Chem., Int. Ed., 48, 9164-9166 (2009)
  2. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: The Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids.
    Org. Biomol. Chem., 7, 3805-3809 (2009)
  3. Nami Ohashi, Wataru Nomura, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura
    Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding.
    J. Pept. Sci., 5(10), 642-646 (2009)
  4. Yuka Inaba, Nobuko Yoshimoto, Yuta Sakamaki, Makoto Nakabayashi, Teikichi Ikura, Hirokazu Tamamura, Nobutoshi Ito, Masato Shimizu & Keiko Yamamoto
    A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor.
    J. Med. Chem., 52(5), 1438-1449 (2009)
  5. Fuminori Mizukoshi, Kenji Baba, Yuko Goto-Koshino, Asuka Setoguchi-Mukai, Yasuhito Fujino, Koichi Ohno, Hirokazu Tamamura, Shinya Oishi, Nobutaka Fujii & Hajime Tsujimoto
    Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus.
    J. Vet. Med. Sci., 71(1), 121-124 (2009)

原著論文　2008

  1. Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore.
    Org. Biomol. Chem., 6, 4374-4377 (2008)
  2. Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto & Hirokazu Tamamura
    Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening.
    Bioconjugate Chem., 19, 1917-1920 (2008)
  3. Hirotomo Nakata, Seth M. Steinberg, Yasuhiro Koh, Kenji Maeda, Yoshikazu Takaoka, Hirokazu Tamamura, Nobutaka Fujii & Hiroaki Mitsuya
    Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs.
    Antimicrob. Agents Chemother., 52(6), 2111-2119 (2008)
  4. Wouter H. P., Driessen, Nobutaka Fujii, Hirokazu Tamamura & Sean M. Sullivan
    Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells.
    Mol. Ther., 16(3), 516-524 (2008)
  5. Alexander Kasiyanov, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    Modulation of Network-driven, GABA-mediated Giant Depolarizing Potentials by SDF-1 in Developing Hippocampus.
    Developmental Neuroscience, 30(4), 285-292 (2008)

原著論文　2007

  1. Kenji Kabashima, Noriko Shiraishi, Kazunari Sugita, Tomoko Mori, Ayako Onoue, Miwa Kobayashi, Jun-ichi Sakabe, Ryutaro Yoshiki, Hirokazu Tamamura, Nobutaka Fujii, Kayo Inaba & Yoshiki Tokura
    CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells.
    Am. J Pathol., 171(4), 1249-1257 (2007)
  2. Kenji Kabashima, Kazunari Sugita, Noriko Shiraishi, Hirokazu Tamamura, Nobutaka Fujii & Yoshiki Tokura
    CXCR4 Engagement Promotes Dendritic Cell Survival and Maturation.
    Biochem. Biophys. Res. Commun., 361, 1012-1016 (2007)
  3. Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii
    Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics.
    Tetrahedron, 63, 9243-9254 (2007)
  4. Yamina A. Berchiche, Ken Y. Chow, Bernard Lagane, Martin Leduc, Yann Percherancier, Nobutaka Fujii, Hirokazu Tamamura, Fran?oise Bachelerie & Nikolaus Heveker
    Direct Assessment of CXCR4 Mutant Conformations Reveals Complex link between Receptor Structure and Galphai Activation.
    J. Biol. Chem. (Commun.), 282, 5111 – 5115 (2007)
  5. Shiro Kubonishi, Tomoko Kikuchi, Shinya Yamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Toshimitsu Matsui, Mitsune Tanimoto & Yoshio Katayama
    Rapid Hematopoietic Progenitor Mobilization by Sulfated Colominic Acid.
    Biochem. Biophys. Res. Commun., 355 (4), 970-975 (2007)
  6. Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jerome Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Peiper & Nobutaka Fujii
    Structure-Activity Relationships of Cyclic Peptide-Based Chemokine Receptor CXCR4 Antagonists: Disclosing the Importance of Side-Chain and Backbone Functionalities.
    J. Med. Chem., 50(2), 192-198 (2007)

原著論文　2006

  1. Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, Stephen C. Peiper, Kazuo Kitaura, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated Anti-S(N)2 ‘ Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists.
    J. Org. Chem., 71 (10), 3942-3951 (2006)
  2. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Satoko Mizokami, Kenichi Hiramatsu, Zixuan Wang, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper & Nobutaka Fujii
    Development of a Linear Type of Low Molecular Weight CXCR4 Antagonists Based on T140 Analogs.
    Org. Biomol. Chem., 4, 2354-2357 (2006)
  3. Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi & Nobutaka Fujii
    Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure.
    J. Med. Chem., 49 (11), 3412-3415 (2006)
  4. Eline Menu, Kewal Asosingh, Stefano Indraccolo, Hendrik De Raeve, Ivan Van Riet, Els Van Valckenborgh, Isabelle Vande Broek, Nobutaka Fujii, Hirokazu Tamamura, Ben Van Camp & Karin Vanderkerken
    The Involvement of Stromal Derived Factor 1α in Homing and Progression of Multiple Myeloma in the 5TMM Model.
    Haematologica/the Hematology Journal, 91(5), 605-612 (2006)
  5. Hirofumi Hanaoka, Takahiro Mukai, Hirokazu Tamamura, Tomohiko Mori, Seigo Ishino, Kazuma Ogawa, Yasuhiko Iida, Ryuichiro Doi, Nobutaka Fujii & Hideo Saji
    Development of a In-111-Labeled Peptide Derivative Targeting a Chemokine Receptor, CXCR4, for Imaging Tumors.
    Nucl. Med. Biol., 33 (4), 489-494 (2006)
  6. Alexander Kasyanov, Hirokazu Tamamura, Nobutaka Fujii & Huangui Xiong
    HIV-1 gp120 Enhances Giant Depolarizing Potentials via Chemokine Receptor CXCR4 in Neonatal Rat Hippocampus.
    Eur. J. Neuroscience, 23, 1120-1128 (2006)
  7. Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii
    Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides.
    Tetrahedron, 62, 1416-1424 (2006)
  8. Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper & Nobutaka Fujii
    Design and Synthesis of Downsized Metastin (45-54) Analogs with Maintenance of High GPR54 Agonistic Activity.
    Bioorg. Med. Chem. Lett., 16(1), 134-137 (2006)

原著論文　2005

  1. Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Structure-activity Relationship Studies on CXCR4 Antagonists Having Cyclic Pentapeptide Scaffolds.
    Org. Biomol. Chem., 3, 4392-4394 (2005)
  2. Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum
    New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion.
    Eur. Urol., 48 (6), 1025-1030 (2005)
  3. Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Photolabile Protection for One-Pot Sequential Native Chemical Ligation.
    ChemBioChem, 6 (11), 1983-1986 (2005)
  4. Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent
    A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools.
    QSAR Comb. Sci., 24 (5), 620-630 (2005)
  5. Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2′ Reactions.
    Tetrahedron Lett., 46, 4183-4186 (2005)
  6. Meike Burger, Tanja Hartmann, Myriam Krome, Justyna Rawluk, Hirokazu Tamamura, Nobutaka Fujii, Thomas J. Kipps & Jan A. Burger
    Small Peptide Inhibitors of the CXCR4 Chemokine Receptor (CD184) Antagonize the Activation, Migration and Antiapoptotic Responses of CXCL12 in Chronic Lymphocytic Leukemia B Cells.
    Blood, 106 (5), 1824-1830 (2005)
  7. Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide-scaffolds.
    J. Med. Chem., 48, 3280-3289 (2005)
  8. Yann Percherancier, Yamina Berchiche, Isabelle Slight, Rudolf Volkmer-Engert, Hirokazu Tamamura, Nobutaka Fujii, Michel Bouvier & Nikolaus Heveker
    Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers.
    J. Biol. Chem., 280, 9895 – 9903 (2005)
  9. Andrew C. W. Zannettino, Amanda N. Farrugia, Angela Kortesidis, Jim Manavis, Luen B. To, Sally K. Martin, Peter Diamond, Hirokazu Tamamura, Tsvee Lapidot, Nobutaka Fujii & Stan Gronthos
    Elevated Serum Levels of SDF-1α are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients.
    Cancer Res., 65(5), 1700-1709 (2005)
  10. Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii & Masao Matsuoka
    Mutations Conferring Resistance to HIV-1 Fusion Inhibitors Are Restricted by gp41 and Rev Responsive Element Functions.
    J. Virol., 79, 764-770 (2005)
  11. Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.
    J. Med. Chem., 48, 380-391 (2005)
  12. Erich Piovan, Valeria Tosello, Stefano Indraccolo, Anna Cabrelle, Ilenia Baesso, Livio Trentin, Rita Zamarchi, Hirokazu Tamamura, Nobutaka Fujii, Gianpietro Semenzato, Luigi-Chieco Bianchi & Alberto Amadori
    Chemokine Receptor Expression in EBV-associated Lymphoproliferation in Hu/SCID Mice: Implications for CXCL12/CXCR4 Axis in Lymphoma Generation.
    Blood, 105, 931-939 (2005)

著書

  1. 玉村啓和
    「第4章 最近の創薬研究」
    ベーシック薬学教科書シリーズ『創薬科学・医薬化学（第2版）』（株式会社　化学同人　京都）、25-64、2022.
  2. 小早川 拓也、辻 耕平、玉村 啓和
    「第１０章 ウイルス疾患に対するワクチン・抗体・阻害剤開発　第２節「種々の作用点をターゲットとした抗HIV剤の創製」」
    創薬研究者がこれだけは知っておきたい最近のウイルス学（株式会社　技術情報協会　東京）、440-451、2021.
  3. 小早川 拓也、玉村 啓和
    「第14章 抗HIV剤を指向したペプチドミメティック」
    生体分子と疾患―ヘルスサイエンスの切り札としての化学（日本化学会　編）（株式会社　化学同人　京都）、128-137、2021.
  4. Takuya Kobayakawa & Hirokazu Tamamura
    “Chloroalkene Dipeptide Isosteres as Peptidomimetics”
    In “Methods in Enzymology on Synthetic and Enzymatic Modifications of the Peptide Backbone,” Elsevier Inc., Vol. 656, pp. 191-239, 2021.doi.prg/10.1016/bs.mie.2021.04.015
  5. Tetsuo Narumi & Hirokazu Tamamura (edition)
    “PEPTIDE SCIENCE 2019” The Japanese Peptide Society, 4-1-2 Ina, Minoh, Osaka 562-8686, Japan, pp. 1-188, 2020.
  6. 小早川 拓也、玉村 啓和
    「第３章 ペプチド医薬に関連した今後の特許戦略と開発動向　第５節「ペプチドミメティクス技術の現状と今後の動向」」
    医薬品モダリティの特許戦略と技術開発動向（株式会社　技術情報協会　東京）、218-225、2019.
  7. 小早川 拓也、玉村 啓和
    「第II編 第6章 ペプチドミメティックを活用した中分子型創薬リードの創製」
    ペプチド創薬の最前線「監修　木曽良明」（株式会社　シーエムシー出版　東京）、48-60、2019.
  8. 小早川 拓也、玉村 啓和
    「第II編 第3章 ペプチドミメティック（ジペプチドイソスター）の合成と応用」
    中分子医薬開発に資するペプチド・核酸・糖鎖の合成・高機能化技術「監修　千葉一裕」（株式会社　シーエムシー出版　東京）、36-48、2018.
  9. Hirokazu Tamamura, Takuya Kobayakawa & Nami Ohashi
    “Mid-Size Drugs Based on Peptides and Peptidomimetics: A New Drug Category”
    In “Springer Briefs in Pharmaceutical Science & Drug Development,” Springer, 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore, pp. 1-100, 2018.
  10. 玉村 啓和、大橋 南美
    「第２章 ペプチドミメティックの開発と中分子創薬研究への応用　第１節「ペプチドミメティックを活用した中分子創薬研究」
    ペプチド医薬品のスクリーニング・安定化・製剤化技術（株式会社　技術情報協会　東京）、85-96、2017.
  11. Nami Ohashi, & Hirokazu Tamamura
    “Peptide-derived mid-sized anti-HIV agents”
    In “Amino Acids, Peptides and Proteins,” ed. by Maxim Ryadnov and Ferenc Hudecz, The Royal Society of Chemistry, Cambridge CB4 0WF, UK, vol. 41, pp. 1-29, 2017.
  12. 野村 渉、田中 智博、玉村 啓和
    「HIV阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
    pp101-107.　ペプチド医薬の最前線. (株)シーエムシー出版. 2012.
  13. Masuda A, Nomura, W, Ohba K, Yamamoto N, Tamamura H.
    Studies for Optimum Design of Artificial Zinc Finger Recombinases by Evaluation of Effects of DNA Binding Affinity and Linker Components on Recombination Efficiency.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 130-131, 2011.
  14. Nomura W, Nakahara T, Hashimoto C, Ohba K , Narumi T, Yamamoto N, Tamamura T.
    Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 132-133, 2011.
  15. Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
    Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells.
    Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 134-135, 2011.
  16. Narumi T, Bode JW.
    α,α-Dicholoroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation of α-Peptide α-Ketoacids.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 178, 2011.
  17. Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
    Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 220, 2011.
  18. Hashimoto C, Narumi T, Nomura W, Yamamoto N, Tamamura H.
    ynthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 103, 2011.
  19. Nomura W, Ohashi N, Mori A, Narumi T, Tanaka T, Masuda A, Tsutsumi H, Tamamura H.
    Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells.
    Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 40, 2011.
  20. Tanaka T, Nomura W, Narumi T, Yoshimura K, Matsushita S, Murakami T,　Komano J, Yamamoto N & Tamamura H
    From reverse to forward chemical genomics: Development of anti-HIV agent.
    Peptide Science 2009, Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka, 105-106, 2010.
  21. Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S & Fujii N
    Stereoselective Synthesis of Peptidomimetics Based on Acid-catalyzed Ring-opening of beta-Aziridinyl-alpha,beta-enoates.
    Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 149-150, 2009.
  22. Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N
    Development of Chemokine Receptor CXCR4 Antagonists Using Bio-mimetic Strategy.
    Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 145-146, 2009.
  23. Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T,　Ohba K, Yamamoto N, Fujii N & Tamamura H
    Structure-activity relationship study of CXCR4 antagonists on the cyclic pentapeptide scaffold: Identification of new pharmacophore moieties.
    Peptide Science 2008, Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka, 273-276, 2009.
  24. Kobayashi K, Narumi T, Oishi S, Ohno H, Fujii N
    Diastereoselective synthesis of trifuluoromethylalkene dipeptide isosters based on nucleophilic trifluoromethylaion.
    Peptide Science 2008, Motoyoshi Nomizu(Eds.), The Japanese peptide Society, Osaka, 13-14, 2009.
  25. Ohashi N, Kato M, Matsumoto H, Tanaka T, Tsutsumi H, Masuno H, Nomura W, Yoshida K, Ikura T, Ito N & Tamamura H.
    Chemical Synthesis of a PKC C1b Domain by a Peptide Ligation Method and Expression of the Protein in E. coli and Their Application.
    4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
  26. Tamamura H, Komano A, Nakahara T, Ohashi1 N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto N.
    Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
    4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
  27. Tsutsumi H, Tanabe Y, Abe S, Mino T, Ohashi N, Tanaka T, Nomura W & Tamamura H.
    Development of Peptide Tools for Fluorescence Imaging of Proteins in Living Cells.
    Peptide Science 2007, Saburo Amimoto and Shin Ono,(Eds.), The Japanese peptide Society, Osaka, 95-96, 2008.
  28. Tamamura H, Komano A, Nakahara T, Ohashi N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto　N.
    Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
    Peptide Science 2007, Saburo Amimoto and Shin Ono (Eds.), The Japanese peptide Society, Osaka, 335-336, 2008.
  29. Tamamura H, Tsutsumi H Masuno H, Ogawa T, Kenichi Hiramatsu K, Takanobu Araki T, Ueda S, Oishi S, Esaka A, Tanaka T, Ohashi N, Wang Z, Peiper SC, Trent JO, ＆ Fujii N
    Synthesis and biological evaluation of CXCR4 antagonists as pharmaceutical agents,
    Peptides 2006, Rolka K. and. Rekowski P. and. Silberring J.,(Eds.), KENES, Geneva, 110-111, 2007.
  30. 濱崎 啓太、堤 浩
    ナノマテリアル・シクロデキストリン.
    pp129-148．シクロデキストリン学会編．米田出版．2005．

英文総説

  1. Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura
    Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines.
    Biopolymers: Peptide Science, 106(4), 622-628 (2016)
  2. Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura
    Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C.
    Biopolymers: Peptide Science, 100(6), 613-620 (2013)
  3. Chie Hashimoto, Tomohiro Tanaka, Tetsuo Narumi, Wataru Nomura & Hirokazu Tamamura
    The Success and Failures of HIV Drug Discovery.
    Expert Opin. Drug Discov., 6, 1067-1090 (2011)
  4. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii
    A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists.
    Expert Opin. Drug Discov., 3(10), 1155-1166 (2008)
  5. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura & Nobutaka Fujii
    Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing.
    Perspec. Medicin. Chem., 2, 1-9 (2008)
  6. Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Shinya Oishi & Nobutaka Fujii
    Therapeutic Potential of the Chemokine Receptor CXCR4 Antagonists as Multi-functional Agents.
    Biopolymers: Peptide Science, 88(2), 279-289 (2007)
  7. Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii
    Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis.
    Lett. Drug Design Discovery, 4, 20-26 (2007)
  8. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno & Nobutaka Fujii
    Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-scaffolds towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Curr. Med. Chem., 14 (1), 93-102 (2007)
  9. Hirokazu Tamamura, Hiroshi Tsutsumi & Nobutaka Fujii
    The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases.
    Mini-Rev. Med. Chem., 6 (9), 109-120 (2006)
  10. Hirokazu Tamamura & Hiroshi Tsutsumi
    Specific Probes for Chemokine Receptors.
    Chem. Biol., 13, 8-10 (2006)
  11. Hirokazu Tamamura & Nobutaka Fujii
    The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Expert Opin. Ther. Targets, 9 (6),1267-1282 (2005)
  12. Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
    Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides.
    Curr. HIV Res., 3 (4), 289 – 301 (2005)

和文総説

  1. 玉村 啓和
    「HIVの研究を基盤とした抗SARS-CoV-2剤の創製」
    MEDCHEM NEWS（日本薬学会 医薬化学部会　東京）、33巻、4号、187-192、2023年 
  2. 玉村 啓和
    「創薬を先導する中分子ペプチド」
    月刊「細胞」（株式会社　ニューサイエンス社　東京）、55巻、9号、660-661、2023年
  3. 小早川 拓也、辻 耕平、玉村 啓和
    「ペプチドミメティックを活用した中分子型創薬リードの創製」
    「月刊バイオインダストリー」特集“ペプチド医薬の最新動向～広い観点からのペプチド創薬科学～” 「監修　木曽良明」（株式会社　シーエムシー出版　東京）、39巻、5号、69-84、2022年
  4. 野村 渉、玉村 啓和
    「HIV-1阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
    「月刊バイオインダストリー」特集“ペプチド医薬の最新動向～広い観点からのペプチド創薬科学～” 「監修　木曽良明」（株式会社　シーエムシー出版　東京）、39巻、5号、15-25、2022年
  5. 玉村 啓和、小早川 拓也、辻 耕平
    「環状ペプチドで標的細胞へターゲティングする」
    「Drug Delivery System」特集“中分子創薬とDDS”（日本DDS学会　東京）、35巻、3号、170-180、2020年
  6. 野村 渉、玉村 啓和
    「細胞内タンパク質を可視化するタグ—蛍光プローブシステム」
    「生化学」みにれびゅう（日本生化学会　東京）、89巻、1号、頁1-6、2017年
  7. 大橋 南美、玉村 啓和
    「ペプチドミメティックを活用した中分子創薬の研究」
    化学工業　特集「ペプチド化学の最前線(I)」 （化学工業社　川崎）、67巻 10号 頁9-17、2016年
  8. 玉村 啓和
    「中分子創薬の可能性―ペプチドを創薬へと展開するー」
    現代化学（株式会社　東京化学同人）、6月号 543号 頁47-51、2016年
  9. 野村 渉、玉村 啓和
    「多価型CXCR4リガンドの創製とがん細胞イメージング・検出」
    医学のあゆみ　第5土曜特集「GPCR研究の最前線2016」 （医歯薬出版株式会社　東京）、256巻 5号 頁430-437、2016年
  10. 野村 渉、玉村 啓和
    「ターゲットタンパク質を特異的に認識するプローブ」
    「化学工業」特集「ペプチド化学の新潮流(I)」（化学工業社　川崎）、65(11)巻 頁8～14、2014年
  11. 玉村 啓和
    「ペプチドミメティックスを活用した抗HIV剤の創製」
    「MEDCHEM NEWS」（日本薬学会 医薬化学部会）、24(1)巻 頁14～19、2014年
  12. 玉村 啓和
    「ケミカルバイオロジーを基盤とした抗HIV剤の創製」
    「薬学雑誌」（日本薬学会）、131(1)巻 頁69～78、2012年
  13. 野村 渉、田中 智博、相川 春夫、玉村 啓和
    「多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用」
    pp267-273．最新ペプチド合成技術とその創薬研究への応用．株式会社　メディカルドゥ．2012
  14. 鳴海 哲夫、Jeffrey W. Bode
    「α-ケト酸とヒドロキシアミンの化学選択的なライゲーション反応によるペプチド合成」
    pp68-75．最新ペプチド合成技術とその創薬研究への応用．株式会社　メディカルドゥ．2012
  15. 鳴海 哲夫、玉村 啓和
    「ペプチドミメティックによる創薬研究」
    「生化学」特集号「ペプチド科学と生化学の接点」（日本生化学会　東京）、第82巻6号　頁515－523、2010年
  16. 野村 渉、増田 朱美、玉村 啓和
    「エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製」
    「生化学」ミニレビュウ（日本生化学会　東京）、第82巻5号　頁393－397、2010年
  17. 橋本 知恵、玉村 啓和
    「タンパク質半合成技術を用いたプロテインスプライシング機構の律速段階を実証した」
    「ケミカルバイオロジー」（日本ケミカルバイオロジー学会　東京）、第3巻2号　頁15、2010年
  18. 玉村 啓和
    「種々の作用点をターゲットとした抗HIV剤の創製」
    日本エイズ学会誌　（日本エイズ学会）、11巻、2号、頁100-101、2009年
  19. 玉村 啓和
    「PK-Cを標的としたdiacylglycerolの環化誘導体の創製」
    ファルマシア　最前線（日本薬学会）、42巻、5号、頁431-435、2006年
  20. 玉村 啓和
    「抗ウイルス薬・抗AIDS (HIV)薬」
    BIO Clinica（北隆館　東京）、21巻、3号、頁224-230、2006年
  21. 藤井 信孝、大高 章、玉村 啓和
    「ケミカルプロテオミクスによる創薬基盤の革新―情報から制御へ」
    細胞工学　特集　飛躍するケミカルバイオロジー: 化学から生命現象を明らかに　(秀潤社　東京）、24巻、11号、頁1181-1186、2005年

オピニオン

  1. 玉村 啓和
    「明日の創薬を先導する中分子「ペプチド」」
    ファルマシア　オピニオン（日本薬学会　東京）、57巻、9号、791、2021年

総説の編集

  1. 玉村啓和
    「中分子ペプチドが拓く明日の創薬」
    月刊「細胞」（株式会社　ニューサイエンス社　東京）、55巻、9号、2023年
  2. Hirokazu Tamamura (Special Issue Editor)
    Molecules “Special Issue “Peptide-Lead Drug Discovery”
    Closed Jan 31, 2020.

研究内容・業績

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