研究業績

原著論文 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005
著書英文総説和文総説オピニオン総説の編集

List of publications of Hirokazu Tamamura, Ph. D.（原著論文、英文総説　※2004年以前を含む)

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原著論文2024

Kouki Shinohara, Takuya Kobayakawa, Kohei Tsuji, Yuki Takamatsu, Hiroaki Mitsuya & Hirokazu Tamamura
Naphthalen-1-ylethanamine–containing small molecule inhibitors of the papain-like protease of SARS-CoV-2.
Eur. J. Med. Chem., 280, 116963(article number) available online: Oct 18 (2024). doi: 10.1016/j.ejmech.2024.116963 (Science Tokyo press release)
Shin-ichiro Hattori, Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, Mi Li, Alexander Wlodawer, Yoshihiro Kawaoka, Shogo Misumi & Hiroaki Mitsuya
Structural and virologic mechanism of the emergence of resistance to Mpro inhibitors in SARS-CoV-2.
Proc. Natl. Acad. Sci. USA, doi.org/10.1073/pnas.2404175121
Kohei Tsuji, Hirokazu Tamamura & Terrence R. Burke, Jr.
Application of a Fluorescence Recovery-based Polo-like Kinase 1 Binding Assay to Polo-like Kinase 2 and Polo-like Kinase 3.
Biol. Pharm. Bull., 47 (7), 1282-1287 (2024). doi.org/10.1248/bpb.b24-00189 (Featured Article)
Kohei Tsuji, Hirokazu Tamamura & Terrence R. Burke, Jr.
Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component.
RSC Chem. Biol., Online Publication Date: Jun 4 (2024). doi.org/10.1039/ d4cb00031e (Inside Front Cover, TMDU press release)
Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kiyomi Nigorikawa, Peter Bolah, Airi Noborio, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Wataru Nomura, Hiroaki Mitsuya, Kenji Maeda & Hirokazu Tamamura
Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents
ACS Infect. Dis., 10 (6), 2250-2261 (2024). doi.org/10.1021/acsinfecdis.4c00194 (Supplementary Journal Cover, TMDU press release)
Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Peter Bolah, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
Effect of two-photon excitation to 8-azacoumarin derivatives as photolabile protecting groups
Chem. Pharm. Bull., 72 (3), 311-312 (2024). doi.org/10.1248/cpb.c24-00013 (Featured Article)

原著論文2023

Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Sayaka Boku, Masaki Kurakami, Masayuki Fujino, Takahiro Ishii, Yutaro Miura, Soshi Nishimura, Kouki Shinohara, Kenichi Yamamoto, Peter Bolah, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
Development of small-molecule anti-HIV-1 agents targeting HIV-1 capsid proteins.
Chem. Pharm. Bull., 72 (1), 41-47 (2024). doi.org/10.1248/cpb.c23-00618
Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement.
Chem. Pharm. Bull., 71, 879-886 (2023). doi.org/10.1248/cpb.c23-00562
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
Structure–Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moietie.
J. Med. Chem., 66, 13516-13529 (2023). doi.org/10.1021/acs.jmedchem.3c00777 (TMDU press release)
Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka & Hirokazu Tamamura
Development of Anti-HBV Agents Targeting HBV Capsid Proteins.
RSC. Med. Chem., 14, 1973-1980 (2023). doi.org/10.1039/d3md00258f (TMDU press release) (Front Cover)
Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda & Hirokazu Tamamura
Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity.
Eur. J. Med. Chem., 256, 115449(article number) published: Aug 05 (2023). doi: 10.1016/j.ejmech.2023.115449 (TMDU press release, TMDU Int’l press release)
Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki & Hirokazu Tamamura
Dimerized Fusion Inhibitor Peptides Targeting the HR1-HR2 Interaction of SARS-CoV-2.
RSC Adv., 13, 8779-8793 (2023). doi: 10.1039/d2ra07356k
Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura & Hiroaki Mitsuya
Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature Commun., 14, 1076(article number) (2023). doi: 10.1038/s41467-023-36729-0
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Yuki Kishihara, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
Low-molecular-weight Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins.
RSC Adv., 13, 2156-2167 (2023). doi: 10.1039/d2ra06837k
Kanako Matsuura, Mizuki Yamaura, Hiromi Sakawaki, Ai Himeno, Yalcin Pisil, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Shuzo Matsushita & Tomoyuki Miura
Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C.
Virology, 578, 171-179 (2023). doi.org/10.1016/j.virol.2022.12.004

原著論文2022

Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda & Hiroaki Takeuchi
4-Phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells.
Biochem. Biophys. Res. Commun., 641, 139-147 (2023). doi.org/10.1016/j.bbrc.2022.12.024
Kaho Matsumoto, Takeo Kuwata, William Tolbert, Jonathan Richard, Shilei Ding, Jérémie Prévost, Shokichi Takahama, George Judicate, Takamasa Ueno, Hirotomo Nakata, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Amos Smith III, Marzena Pazgier, Andrés Finzi & Shuzo Matsushita
Characterization of a novel CD4 mimetic compound YIR-821 against HIV-1 clinical isolates.
J. Virol., 97 (1), e01638-22 (2023). doi.org/10.1128/jvi.01638-22
Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors.
Bioorg. Med. Chem., 76, 117083(article number) (2022). doi.org: 10.1016/j.bmc.2022.117083
Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya & Hirokazu Tamamura
Potent and Biostable Inhibitors of the Main Protease of SARS-CoV-2.
iScience, 25 (11), 105365(article number) published: Nov 01 (2022). doi.org/10.1016/j.isci.2022.105365 (TMDU press release, TMDU Int’l press release)
Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinovd & Terrence R. Burke, Jr.
Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.
RSC Chemical Biology, 3 (9), 1111-1120 (2022). doi: 10.1039/D2CB00153E (Back Cover picture)
Kohei Tsuji, Takuya Kobayakawa, Kiju Konno, Ami Masuda, Kohei Takahashi, Nami Ohashi, Kazuhisa Yoshimura, Takeo Kuwata, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
Exploratory Studies on Soluble Small Molecule CD4 Mimics as HIV Entry Inhibitors.
Bioorg. Med. Chem., 56, 116616(article number) (2022). doi.org: 10.1016/j.bmc.2022.116616 (Cover picture)

原著論文2021

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, & Hirokazu Tamamura
Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-Methoxynaphthalene-labeled 1,2-Diacylglycerol-lactones
Org. Biomol. Chem., 19(38), 8264-8271 (2021). doi: 10.1039/d1ob00814e (Inside Front Cover)
Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji & Hirokazu Tamamura
Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application
J. Org. Chem., 86(7), 5091-5101 (2021). doi.org: 10.1021/acs.joc.0c03019 (TMDU & TOYAKU press release)
Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda
A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells with a Combination of Latency-reversing Agents Containing DAG-lactone PKC Activators
Frontiers in Microbiology, 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021.
Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura & Shiroh Futaki
Discovery of a Macropinocytosis-inducing Peptide Potentiated by Medium-mediated Intramolecular Disulfide Formation
Angew. Chem., Int. Ed., 60(21), 11928-11936 (2021). doi: 10.1002/anie.202016754
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
Small-molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins.
Biomolecules, 11, 208 (2021). https://doi.org/10.3390/biom11020208 (TMDU & AMED press release)
Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors.
J. Med. Chem.,64(3), 1481-1496 (2021). doi.org: 10.1021/acs.jmedchem.0c01153 (Supplementary Journal Cover, TMDU & AMED press release)
Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Kofi Baffour-Awuah Owusu, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Potent Leads Based on CA-19L, an Anti-HIV Active HIV-1 Capsid Fragment.
Bioorg. Med. Chem., 30, 115923 (2021). doi.org: 10.1016/j.bmc.2020.115923 (Cover picture)

原著論文2020

Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Shows Improved Genome Editing Accuracy.
Communications Biology, 3, 1-10 (2020). doi: 10.1038/s42003-020-01340-2　(TMDU & Hiroshima Univ. press release)
Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura
Bivalent HIV-1 Fusion Inhibitors Based on Peptidomimetics.
Bioorg. Med. Chem., 28(24), 115812 (2020). doi.org: 10.1016/j.bmc.2020.115812
Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications.
Org. Biomol. Chem., 18, 4217-4223 (2020). doi: 10.1039/d0ob00807a
Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Exploratory Studies on CA-15L, an Anti-HIV Active HIV-1 Capsid Fragment.
Bioorg. Med. Chem., 28(11), 115488 (2020). doi.org: 10.1016/j.bmc.2020.115488
Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases.
Biochemistry, 59(2), 197-204 (2020). doi: 10.1021/acs.biochem.9b00798

原著論文　2019

Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura & Shuzo Matsushita
Synergistic Inhibition of Cell-to-cell HIV-1 Infection by Combinations of Single Chain Variable Fragments and Fusion Inhibitors.
Biochem Biophys Rep., 20, (2019). Sep 21; doi: 10.1016/j.bbrep.2019.100687. eCollection 2019 Dec.
Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors.
ChemBioChem: Special Issue dedicated to the 10th IPS in Kyoto, 20(16) 2101-2108 (2019). doi: 10.1002/cbic.201900187 (Cover picture)
Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands.
Bioconjugate Chem., 30(5), 1442-1450 (2019). doi: 10.1021/acs.bioconjchem.9b00182
Maxwell M. Sakyiamah, Takuya Kobayakawa, Masayuki Fujino, Makoto Konno, Tetsuo Narumi, Tomohiro Tanaka, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Design, Synthesis and Biological Evaluation of Low Molecular Weight CXCR4 Ligands.
Bioorg. Med. Chem.: Special Issue entitled “Strategic Basic Molecular Medicinal Chemistry,” 27(6), 1130-1138 (2019). doi.org/10.1016/j.bmc.2019.02.013
Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada & Hirokazu Tamamura
Soluble-type Small-molecule CD4 Mimics as HIV Entry Inhibitors.
Bioorg. Med. Chem. Lett., 29(5), 719-723 (2019). doi.org/10.1016/j.bmcl.2019.01.011
Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-ichiro Hattori, Wataru Nomura, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya & Kenji Maeda
Benzolactam-Related Compounds Promote Apoptosis Via Protein Kinase C-Induced HIV Latency Reversal.
J. Biol. Chem., 294(1), 116-129 (2019). doi: 10.1074/jbc.RA118.005798.
Akinobu Z. Suzuki, Ryota Sekine, Shiori Takeda, Ryosuke Aikawa, Yukiko Shiraishi, Tomomi Hamaguchi, Hiroyuki Okuno, Hirokazu Tamamura & Toshiaki Furuta
A Clickable Caging Group as a New Platform for Modular Caged Compounds with Improved Photochemical Properties.
Chem. Comm., 55, 451-454 (2019). doi: 10.1039/c8cc07981a

原著論文　2018

Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa & Hirokazu Tamamura
Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors.
Biochemistry, 57(45), 6452-6459 (2018). doi: 10.1021/acs.biochem.8b00741
Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
Flexibility of Small Molecular CD4 Mimics as HIV Entry Inhibitors.
Bioorg. Med. Chem., 26(21), 5664-5671 (2018). doi.org: 10.1016/j.bmc.2018.10.011
Kei Toyama, Takuya Kobayakawa, Wataru Nomura & Hirokazu Tamamura
Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
Chem. Pharm. Bull., 66(11), 1083-1089 (2018).
Kei Toyama, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
Bioconjugate Chem., 29(6), 2050-2057 (2018). doi: 10.1021/acs.bioconjchem.8b00250
Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu & Hirokazu Tamamura
Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.
ACS Med. Chem. Lett., 9(1), 6-10 (2018). doi: 10.1021/acsmedchemlett.7b00234

原著論文　2017

Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura
Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
Bioconjugate Chem., 28(8), 2135-2144 (2017)
Takuya Kobayakawa & Hirokazu Tamamura
Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation.
Tetrahedron, 73(30), 4464-4471 (2017)
Kazuya Kobayashi, Takaaki Mizuguchi, Yasunao Hattori, Naho Ohara, Ryunosuke Ninomiya, Mika Iida, Honami Ooe, Yukako Yamazaki, Minami Takata, Hirokazu Tamamura & Kenichi Akaji
Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor.
J. Pept. Sci., 23(7-8), 581-586 (2017)
Hikaru Takano, Tetsuo Narumi, Wataru Nomura, and Hirokazu Tamamura
Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
J. Org. Chem., 82(5), 2739-2744 (2017)
Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells.
J. Pept. Sci., 23(7-8), 574-580 (2017)
Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Development of Anti-HIV Peptides Based on a Viral Capsid Protein.
Biopolymers: Peptide Science, 2017 Jan;108(1). doi: 10.1002/bip.22920 (2017)

原著論文　2016

Tomofumi Nakamura, Joseph R. Campbell, Amber R. Moore, Sachiko Otsu, Haruo Aikawa, Hirokazu Tamamura & Hiroaki Mitsuya
Development and Validation of a Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization.
J. Virol. Methods, 236, 196-206 (2016)
Takuya Kobayakawa & Hirokazu Tamamura
Efficient Synthesis of Xaa-Gly Type (Z)-Chloroalkene Dipeptide Isosteres via Organocuprate Mediated Reduction.
Tetrahedron, 72(32), 4968-4971 (2016)
Kei Toyama, Takaaki Mizuguchi, Wataru Nomura & Hirokazu Tamamura
Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization.
Bioorg. Med. Chem., 24(16), 3406-3412 (2016)
Kenichi Hiramatsu & Hirokazu Tamamura
A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst.
Eur. J. Org. Chem., 2016(21), 3491-3494 (2016)
Aisha Abduelmula, Ruijin Huang, Qin Pu, Hirokazu Tamamura, Gabriela Morosan-Puopolo & Beate Brand-Saberi
SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite.
Int. J. Dev. Biol., 60(1-2-3), 29-38 (2016)
Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, and Tom W. Muir
Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.
Nat Commun., doi: 10.1038/ncomms10589 (2016)
Kenichi Hiramatsu, Takashi Honjo, Vivek Rauniyar, and F. Dean Toste
Enantioselective Synthesis of Fluoro−Dihydroquinazolones and −Benzooxazinones by Fluorination-Initiated Asymmetric Cyclization Reactions.
ACS Catal., 6 (1), 151–154 (2016)
Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura　& Hirokazu Tamamura
Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.
ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions, 11(8), 940-946 (2016)
Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori; Yu Irahara; Yuko Yamada; Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.
Bioorg. Med. Chem. Lett., 26(2), 397-400 (2016)

原著論文　2015

Hikaru Takano, Tetsuo, Narumi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group.
Org. Lett., 17(21), 5372-5375 (2015)
Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.
Bioorg. Med. Chem., 23(21), 6967-6973 (2015)
Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.
Org. Biomol. Chem., 13(32), 8734-8739 (2015)
Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.
Bioorg. Med. Chem., 23(15), 4423-4427 (2015)
Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura
An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides.
Bioconjugate Chem., 26(6), 1080-1085 (2015)
Takuya Kobayakawa, Tetsuo Narumi & Hirokazu Tamamura
Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres.
Org. Lett., 17(10), 2302-2305 (2015)

原著論文　2014

Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura
Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.
Chem. Pharm. Bull.,62(10), 1019-1025 (2014)
Maryna Masyuk, Aisha Abduelmula, Gabriela Morosan-Puopolo, Veysel Odemis, Rizwan Rehimi, Nargis Khalida, Faisal Yusuf, Jurgen Engele, Hirokazu Tamamura, Carsten Theiss & Beate Brand-Saberi
Retrograde Migration of Pectoral Girdle Muscle Precursors Depends on CXCR4/SDF-1 Signaling.
Histochem. Cell. Biol.,142(5), 473-488 (2014)
Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.
Tetrahedron, 70(34), 5122-5127 (2014)
Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura
Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups.
Tetrahedron, 70(29), 4400-4404 (2014)
Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.
Org. Biomol. Chem., 12(23), 3821-3826 (2014)
Tetsuo Narumi, Seiji Tsuzuki & Hirokazu Tamamura
Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab Initio Calculations.
Asian J. Org. Chem., 3(4), 497-503 (2014)
Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura
Isostere-Based Design of 8-Azacoumarin-Type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls.
Org. Lett., 16(4), 1184-1187 (2014)

原著論文　2013

Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura
A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics.
Bioorg. Med. Chem., 21(24), 7884-7889 (2013)
Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies.
Bioorg. Med. Chem., 21(22), 6878-6885 (2013)
Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi
Generation of a Replication-competent Simian-human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic.
J. Gen.Virol., 94(12), 2710-2716 (2013)
Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4.
ChemMedChem, 8(10), 1668-1672 (2013)
Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura
Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.
ACS Chem. Biol., 8(10), 2235-2244 (2013)
Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors.
Bioorg. Med. Chem., 21(15), 4452-4458 (2013)
Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.
Bioorg. Med. Chem., 21(9), 2518-2526 (2013)
Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
Low Molecular Weight CXCR4 Ligands with Variable Spacers.
ChemMedChem, 8(1), 118-124 (2013)

原著論文　2012

Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura
Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation.
Org. Lett., 14, 4490-4493 (2012)
Tetsuo Narumi, Tomohiro Tanaka, Chie Hashimoto, Wataru Nomura, Haruo Aikawa, Akira Sohma, Kyoko Itotani, Miyako Kawamata, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
Pharmacophore-Based Small Molecule CXCR4 Ligands.
Bioorg. Med. Chem. Lett., 22, 4169-4172 (2012)
Chie Hashimoto, Wataru Nomura, Aki Ohya, Emiko Urano, Kosuke Miyauchi, Tetsuo Narumi, Haruo Aikawa, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines.
Bioorg. Med. Chem.,　20, 3287-3291 (2012)
Wataru Nomura, Akemi Masuda, Kenji Ohba, Arisa Urabe, Nobutoshi Ito, Akihide Ryo, Naoki Yamamoto & Hirokazu Tamamura
Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion. on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined　by a Facile Fluorescent System.
Biochemistry, 51, 1510-1517 (2012)
Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun Komano, Naoki Yamamoto & Hirokazu Tamamura
A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency.
ChemMedChem, 7, 205-208 (2012)
Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins.
Bioorg. Med. Chem., 20, 1468-1474 (2012)

原著論文　2011

Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
Small Molecular CD4 Mimics as HIV Entry Inhibitors.
Bioorg. Med. Chem., 19, 6735-6742 (2011)
Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii & Mitsuo Kaku
The Increase in Surface CXCR4 Expression on　Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury.
Cell Mol. Immunol., 8, 305-314 (2011)
Changshui Xu, Jianuo Liu, Lina Chen, Shangdong Liang, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
HIV-1 gp120 Enhances Outward Potassium Current via CXCR4 and cAMP-Dependent Protein Kinase a Signaling in Cultured Rat Microglia.
Glia., 59, 997-1007 (2011)
Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura
Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore.
Bioconjugate Chem., 22, 923-930 (2011)
Tomohiro Tanaka, Tetsuo Narumi, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
Azamacrocyclic-metal Complexes as CXCR4 Antagonists.
ChemMedChem, 6, 834-839 (2011)
Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino, Wataru Nomura & Hirokazu Tamamura
Intense Blue Fluorescence in a Leucine Zipper Assembly.
ChemBioChem, 12, 691-694 (2011)
Nami Ohashi, Wataru Nomura, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura
Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding.
Bioconjugate Chem., 22, 82-87 (2011)
Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura
Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C.
ChemBioChem, 12, 535-539 (2011)
Tetsuo Narumi & Jeffrey W. Bode
α,α-Dichloroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation OF α-Peptide α-Ketoacids.
Heterocycles, 82, 1515-1525 (2011)

原著論文　2010

Tetsuo Narumi, Ryoko Hayashi, Kenji Tomita, Kazuya Kobayashi, Noriko Tanahara, Hiroaki Ohno, Takeshi Naito, Eiichi Kodama, Masao Matsuoka, Shinya Oishi & Nobutaka Fujii
Synthesis of Biological Evaluation of Selective CXCR4 Antagonists Containing Alkene Dipeptide Isosteres
Org. Biomol. Chem., 8, 616-621 (2010)
Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda & Hirokazu Tamamura
Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells
J. Am. Chem. Soc.(Commun.),132, 15899-15901 (2010)
Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Shuzo Matsushita & Hirokazu Tamamura
CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist
Bioorg. Med. Chem. Lett., 20, 5853-5858 (2010)
Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano & Hirokazu Tamamura
Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies.
Bioorg. Med. Chem., 18, 6771-6775 (2010)
Shintaro Suzuki, Emiko Urano, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Kasthuraiah Maddali, Yan Han, Makiko Hamatake, Kosuke Miyauchi, Yves Pommier, John A. Beutler, Wataru Sugiura, Hideyoshi Fuji, Tyuji Hoshino, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Jun A. Komano & Hirokazu Tamamura
Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products.
J. Med. Chem., 53(14), 5356-5360 (2010)
Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura & Shuzo Matsushita
Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds.
J. Virol., 84(15), 7558-7568 (2010)
Toru Aoki, Saki Shimizu, Emiko Urano, Yuko Futahashi, Makiko Hamatake, Hirokazu Tamamura, Kazuo Terashima, Tsutomu Murakami, Naoki Yamamoto & Jun Komano
Improvement of Lentiviral Vector-mediated Gene Transduction by Genetic Engineering of the Structural Protein Pr55Gag.
Gene Ther., 17(9), 1124-1133(2010)
Roberta Melchionna, Anna Di Carlo, Roberta De Mori, Claudia Cappuzzello, Laura Barberi, Antonio Musar?, Chiara Cencioni, Nobutaka Fujii, Hirokazu Tamamura, Marco Crescenzi, Maurizio C. Capogrossi, Monica Napolitano & Antonia Germani
Induction of Myogenic Differentiation by SDF-1 via CXCR4 and CXCR7 Receptors.
Muscle Nerve., 41(6), 828-835 (2010)
Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura
Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins.
Biopolymers: Peptide Science, 94, 843-852 (2010)
Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies.
Bioconjugate Chem., 21(4), 709-714 (2010)
Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
CD4 Mimics Targeting the Mechanism of HIV.
Bioorg. Med. Chem. Lett., 20, 354-358 (2010)

原著論文　2009

Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura
Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells.
Angew. Chem., Int. Ed., 48, 9164-9166 (2009)
Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii & Hirokazu Tamamura
Structure-activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: The Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids.
Org. Biomol. Chem., 7, 3805-3809 (2009)
Nami Ohashi, Wataru Nomura, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura
Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding.
J. Pept. Sci., 5(10), 642-646 (2009)
Yuka Inaba, Nobuko Yoshimoto, Yuta Sakamaki, Makoto Nakabayashi, Teikichi Ikura, Hirokazu Tamamura, Nobutoshi Ito, Masato Shimizu & Keiko Yamamoto
A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor.
J. Med. Chem., 52(5), 1438-1449 (2009)
Fuminori Mizukoshi, Kenji Baba, Yuko Goto-Koshino, Asuka Setoguchi-Mukai, Yasuhito Fujino, Koichi Ohno, Hirokazu Tamamura, Shinya Oishi, Nobutaka Fujii & Hajime Tsujimoto
Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus.
J. Vet. Med. Sci., 71(1), 121-124 (2009)

原著論文　2008

Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii & Hirokazu Tamamura
Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore.
Org. Biomol. Chem., 6, 4374-4377 (2008)
Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto & Hirokazu Tamamura
Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening.
Bioconjugate Chem., 19, 1917-1920 (2008)
Hirotomo Nakata, Seth M. Steinberg, Yasuhiro Koh, Kenji Maeda, Yoshikazu Takaoka, Hirokazu Tamamura, Nobutaka Fujii & Hiroaki Mitsuya
Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs.
Antimicrob. Agents Chemother., 52(6), 2111-2119 (2008)
Wouter H. P., Driessen, Nobutaka Fujii, Hirokazu Tamamura & Sean M. Sullivan
Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells.
Mol. Ther., 16(3), 516-524 (2008)
Alexander Kasiyanov, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
Modulation of Network-driven, GABA-mediated Giant Depolarizing Potentials by SDF-1 in Developing Hippocampus.
Developmental Neuroscience, 30(4), 285-292 (2008)

原著論文　2007

Kenji Kabashima, Noriko Shiraishi, Kazunari Sugita, Tomoko Mori, Ayako Onoue, Miwa Kobayashi, Jun-ichi Sakabe, Ryutaro Yoshiki, Hirokazu Tamamura, Nobutaka Fujii, Kayo Inaba & Yoshiki Tokura
CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells.
Am. J Pathol., 171(4), 1249-1257 (2007)
Kenji Kabashima, Kazunari Sugita, Noriko Shiraishi, Hirokazu Tamamura, Nobutaka Fujii & Yoshiki Tokura
CXCR4 Engagement Promotes Dendritic Cell Survival and Maturation.
Biochem. Biophys. Res. Commun., 361, 1012-1016 (2007)
Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii
Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics.
Tetrahedron, 63, 9243-9254 (2007)
Yamina A. Berchiche, Ken Y. Chow, Bernard Lagane, Martin Leduc, Yann Percherancier, Nobutaka Fujii, Hirokazu Tamamura, Fran?oise Bachelerie & Nikolaus Heveker
Direct Assessment of CXCR4 Mutant Conformations Reveals Complex link between Receptor Structure and Galphai Activation.
J. Biol. Chem. (Commun.), 282, 5111 – 5115 (2007)
Shiro Kubonishi, Tomoko Kikuchi, Shinya Yamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Toshimitsu Matsui, Mitsune Tanimoto & Yoshio Katayama
Rapid Hematopoietic Progenitor Mobilization by Sulfated Colominic Acid.
Biochem. Biophys. Res. Commun., 355 (4), 970-975 (2007)
Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jerome Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Peiper & Nobutaka Fujii
Structure-Activity Relationships of Cyclic Peptide-Based Chemokine Receptor CXCR4 Antagonists: Disclosing the Importance of Side-Chain and Backbone Functionalities.
J. Med. Chem., 50(2), 192-198 (2007)

原著論文　2006

Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, Stephen C. Peiper, Kazuo Kitaura, Akira Otaka & Nobutaka Fujii
Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated Anti-S(N)2 ‘ Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists.
J. Org. Chem., 71 (10), 3942-3951 (2006)
Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Satoko Mizokami, Kenichi Hiramatsu, Zixuan Wang, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper & Nobutaka Fujii
Development of a Linear Type of Low Molecular Weight CXCR4 Antagonists Based on T140 Analogs.
Org. Biomol. Chem., 4, 2354-2357 (2006)
Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi & Nobutaka Fujii
Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure.
J. Med. Chem., 49 (11), 3412-3415 (2006)
Eline Menu, Kewal Asosingh, Stefano Indraccolo, Hendrik De Raeve, Ivan Van Riet, Els Van Valckenborgh, Isabelle Vande Broek, Nobutaka Fujii, Hirokazu Tamamura, Ben Van Camp & Karin Vanderkerken
The Involvement of Stromal Derived Factor 1α in Homing and Progression of Multiple Myeloma in the 5TMM Model.
Haematologica/the Hematology Journal, 91(5), 605-612 (2006)
Hirofumi Hanaoka, Takahiro Mukai, Hirokazu Tamamura, Tomohiko Mori, Seigo Ishino, Kazuma Ogawa, Yasuhiko Iida, Ryuichiro Doi, Nobutaka Fujii & Hideo Saji
Development of a In-111-Labeled Peptide Derivative Targeting a Chemokine Receptor, CXCR4, for Imaging Tumors.
Nucl. Med. Biol., 33 (4), 489-494 (2006)
Alexander Kasyanov, Hirokazu Tamamura, Nobutaka Fujii & Huangui Xiong
HIV-1 gp120 Enhances Giant Depolarizing Potentials via Chemokine Receptor CXCR4 in Neonatal Rat Hippocampus.
Eur. J. Neuroscience, 23, 1120-1128 (2006)
Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii
Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides.
Tetrahedron, 62, 1416-1424 (2006)
Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper & Nobutaka Fujii
Design and Synthesis of Downsized Metastin (45-54) Analogs with Maintenance of High GPR54 Agonistic Activity.
Bioorg. Med. Chem. Lett., 16(1), 134-137 (2006)

原著論文　2005

Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
Structure-activity Relationship Studies on CXCR4 Antagonists Having Cyclic Pentapeptide Scaffolds.
Org. Biomol. Chem., 3, 4392-4394 (2005)
Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum
New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion.
Eur. Urol., 48 (6), 1025-1030 (2005)
Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
Photolabile Protection for One-Pot Sequential Native Chemical Ligation.
ChemBioChem, 6 (11), 1983-1986 (2005)
Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent
A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools.
QSAR Comb. Sci., 24 (5), 620-630 (2005)
Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2′ Reactions.
Tetrahedron Lett., 46, 4183-4186 (2005)
Meike Burger, Tanja Hartmann, Myriam Krome, Justyna Rawluk, Hirokazu Tamamura, Nobutaka Fujii, Thomas J. Kipps & Jan A. Burger
Small Peptide Inhibitors of the CXCR4 Chemokine Receptor (CD184) Antagonize the Activation, Migration and Antiapoptotic Responses of CXCL12 in Chronic Lymphocytic Leukemia B Cells.
Blood, 106 (5), 1824-1830 (2005)
Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide-scaffolds.
J. Med. Chem., 48, 3280-3289 (2005)
Yann Percherancier, Yamina Berchiche, Isabelle Slight, Rudolf Volkmer-Engert, Hirokazu Tamamura, Nobutaka Fujii, Michel Bouvier & Nikolaus Heveker
Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers.
J. Biol. Chem., 280, 9895 – 9903 (2005)
Andrew C. W. Zannettino, Amanda N. Farrugia, Angela Kortesidis, Jim Manavis, Luen B. To, Sally K. Martin, Peter Diamond, Hirokazu Tamamura, Tsvee Lapidot, Nobutaka Fujii & Stan Gronthos
Elevated Serum Levels of SDF-1α are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients.
Cancer Res., 65(5), 1700-1709 (2005)
Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii & Masao Matsuoka
Mutations Conferring Resistance to HIV-1 Fusion Inhibitors Are Restricted by gp41 and Rev Responsive Element Functions.
J. Virol., 79, 764-770 (2005)
Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.
J. Med. Chem., 48, 380-391 (2005)
Erich Piovan, Valeria Tosello, Stefano Indraccolo, Anna Cabrelle, Ilenia Baesso, Livio Trentin, Rita Zamarchi, Hirokazu Tamamura, Nobutaka Fujii, Gianpietro Semenzato, Luigi-Chieco Bianchi & Alberto Amadori
Chemokine Receptor Expression in EBV-associated Lymphoproliferation in Hu/SCID Mice: Implications for CXCL12/CXCR4 Axis in Lymphoma Generation.
Blood, 105, 931-939 (2005)

著書

玉村啓和
「第4章最近の創薬研究」
ベーシック薬学教科書シリーズ『創薬科学・医薬化学（第2版）』（株式会社　化学同人　京都）、25-64、2022.
小早川拓也、辻耕平、玉村啓和
「第１０章ウイルス疾患に対するワクチン・抗体・阻害剤開発　第２節「種々の作用点をターゲットとした抗HIV剤の創製」」
創薬研究者がこれだけは知っておきたい最近のウイルス学（株式会社　技術情報協会　東京）、440-451、2021.
小早川拓也、玉村啓和
「第14章抗HIV剤を指向したペプチドミメティック」
生体分子と疾患―ヘルスサイエンスの切り札としての化学（日本化学会　編）（株式会社　化学同人　京都）、128-137、2021.
Takuya Kobayakawa & Hirokazu Tamamura
“Chloroalkene Dipeptide Isosteres as Peptidomimetics”
In “Methods in Enzymology on Synthetic and Enzymatic Modifications of the Peptide Backbone,” Elsevier Inc., Vol. 656, pp. 191-239, 2021.doi.prg/10.1016/bs.mie.2021.04.015
Tetsuo Narumi & Hirokazu Tamamura (edition)
“PEPTIDE SCIENCE 2019” The Japanese Peptide Society, 4-1-2 Ina, Minoh, Osaka 562-8686, Japan, pp. 1-188, 2020.
小早川拓也、玉村啓和
「第３章ペプチド医薬に関連した今後の特許戦略と開発動向　第５節「ペプチドミメティクス技術の現状と今後の動向」」
医薬品モダリティの特許戦略と技術開発動向（株式会社　技術情報協会　東京）、218-225、2019.
小早川拓也、玉村啓和
「第II編第6章ペプチドミメティックを活用した中分子型創薬リードの創製」
ペプチド創薬の最前線「監修　木曽良明」（株式会社　シーエムシー出版　東京）、48-60、2019.
小早川拓也、玉村啓和
「第II編第3章ペプチドミメティック（ジペプチドイソスター）の合成と応用」
中分子医薬開発に資するペプチド・核酸・糖鎖の合成・高機能化技術「監修　千葉一裕」（株式会社　シーエムシー出版　東京）、36-48、2018.
Hirokazu Tamamura, Takuya Kobayakawa & Nami Ohashi
“Mid-Size Drugs Based on Peptides and Peptidomimetics: A New Drug Category”
In “Springer Briefs in Pharmaceutical Science & Drug Development,” Springer, 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore, pp. 1-100, 2018.
玉村啓和、大橋南美
「第２章ペプチドミメティックの開発と中分子創薬研究への応用　第１節「ペプチドミメティックを活用した中分子創薬研究」
ペプチド医薬品のスクリーニング・安定化・製剤化技術（株式会社　技術情報協会　東京）、85-96、2017.
Nami Ohashi, & Hirokazu Tamamura
“Peptide-derived mid-sized anti-HIV agents”
In “Amino Acids, Peptides and Proteins,” ed. by Maxim Ryadnov and Ferenc Hudecz, The Royal Society of Chemistry, Cambridge CB4 0WF, UK, vol. 41, pp. 1-29, 2017.
野村渉、田中智博、玉村啓和
「HIV阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
pp101-107.　ペプチド医薬の最前線. (株)シーエムシー出版. 2012.
Masuda A, Nomura, W, Ohba K, Yamamoto N, Tamamura H.
Studies for Optimum Design of Artificial Zinc Finger Recombinases by Evaluation of Effects of DNA Binding Affinity and Linker Components on Recombination Efficiency.
Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 130-131, 2011.
Nomura W, Nakahara T, Hashimoto C, Ohba K , Narumi T, Yamamoto N, Tamamura T.
Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins.
Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 132-133, 2011.
Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
Development of Bivalent Ligands for CXCR4 with Rigid Linkers and Application to Detection of Cancer Cells.
Proceedings of the Twenty-Second American Peptide Symposium, Michal Lebl (Eds.), American Peptide Society, San Diego, 134-135, 2011.
Narumi T, Bode JW.
α,α-Dicholoroisoxazolidinones for The Synthesis and Chemoselective Peptide Ligation of α-Peptide α-Ketoacids.
Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 178, 2011.
Nomura W, Tanaka T, Masuda A, Narumi T, Tamamura H.
Development of a Bivalent Ligand for a Chemokine Receptor CXCR4 by Utilizing Polyproline Helix as a Linker.
Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 220, 2011.
Hashimoto C, Narumi T, Nomura W, Yamamoto N, Tamamura H.
ynthesis and Evaluation of CXCR4-derived Peptides Targeting the Development of AIDS Vaccines.
Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 103, 2011.
Nomura W, Ohashi N, Mori A, Narumi T, Tanaka T, Masuda A, Tsutsumi H, Tamamura H.
Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells.
Peptide Science 2010, Nobutaka Fujii and Yoshiaki Kiso (Ed.), The Japanese peptide Society, Osaka, 40, 2011.
Tanaka T, Nomura W, Narumi T, Yoshimura K, Matsushita S, Murakami T,　Komano J, Yamamoto N & Tamamura H
From reverse to forward chemical genomics: Development of anti-HIV agent.
Peptide Science 2009, Kouji Okamoto (Ed.), The Japanese peptide Society, Osaka, 105-106, 2010.
Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S & Fujii N
Stereoselective Synthesis of Peptidomimetics Based on Acid-catalyzed Ring-opening of beta-Aziridinyl-alpha,beta-enoates.
Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 149-150, 2009.
Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N
Development of Chemokine Receptor CXCR4 Antagonists Using Bio-mimetic Strategy.
Peptides for Youth, S. Del Valle, E. Escher and W. D. Lubell (Eds.), The American peptide Society, USA, 145-146, 2009.
Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T,　Ohba K, Yamamoto N, Fujii N & Tamamura H
Structure-activity relationship study of CXCR4 antagonists on the cyclic pentapeptide scaffold: Identification of new pharmacophore moieties.
Peptide Science 2008, Motoyoshi Nomizu (Ed.), The Japanese peptide Society, Osaka, 273-276, 2009.
Kobayashi K, Narumi T, Oishi S, Ohno H, Fujii N
Diastereoselective synthesis of trifuluoromethylalkene dipeptide isosters based on nucleophilic trifluoromethylaion.
Peptide Science 2008, Motoyoshi Nomizu(Eds.), The Japanese peptide Society, Osaka, 13-14, 2009.
Ohashi N, Kato M, Matsumoto H, Tanaka T, Tsutsumi H, Masuno H, Nomura W, Yoshida K, Ikura T, Ito N & Tamamura H.
Chemical Synthesis of a PKC C1b Domain by a Peptide Ligation Method and Expression of the Protein in E. coli and Their Application.
4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
Tamamura H, Komano A, Nakahara T, Ohashi1 N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto N.
Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
4th International Peptide Symposium, Cairn, Australia, Oct21-25, 2007, in press.
Tsutsumi H, Tanabe Y, Abe S, Mino T, Ohashi N, Tanaka T, Nomura W & Tamamura H.
Development of Peptide Tools for Fluorescence Imaging of Proteins in Living Cells.
Peptide Science 2007, Saburo Amimoto and Shin Ono,(Eds.), The Japanese peptide Society, Osaka, 95-96, 2008.
Tamamura H, Komano A, Nakahara T, Ohashi N, Tanaka T, Tsutsumi H, Nomura W, Urano E, Hua Y, Fuji H, Hamatake M, Miyauchi K, Morikawa Y, Hoshino T, Sugiura W & Yamamoto　N.
Identification of Sequential Motifs Relevant to Inhibitory Activity against HIV Integrase.
Peptide Science 2007, Saburo Amimoto and Shin Ono (Eds.), The Japanese peptide Society, Osaka, 335-336, 2008.
Tamamura H, Tsutsumi H Masuno H, Ogawa T, Kenichi Hiramatsu K, Takanobu Araki T, Ueda S, Oishi S, Esaka A, Tanaka T, Ohashi N, Wang Z, Peiper SC, Trent JO, ＆ Fujii N
Synthesis and biological evaluation of CXCR4 antagonists as pharmaceutical agents,
Peptides 2006, Rolka K. and. Rekowski P. and. Silberring J.,(Eds.), KENES, Geneva, 110-111, 2007.
濱崎啓太、堤浩
ナノマテリアル・シクロデキストリン.
pp129-148．シクロデキストリン学会編．米田出版．2005．

英文総説

Takuya Kobayakawa, Kohei Tsuji & Hirokazu Tamamura Design, synthesis and evaluation of bioactivity of peptidomimetics based on chloroalkene dipeptide isosteres.
Bioorg. Med. Chem. 110, 117811(article number) (2024).
doi.org/10.1016/j.bmc.2024.117811
Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura
Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines.
Biopolymers: Peptide Science, 106(4), 622-628 (2016)
Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura
Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C.
Biopolymers: Peptide Science, 100(6), 613-620 (2013)
Chie Hashimoto, Tomohiro Tanaka, Tetsuo Narumi, Wataru Nomura & Hirokazu Tamamura
The Success and Failures of HIV Drug Discovery.
Expert Opin. Drug Discov., 6, 1067-1090 (2011)
Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii
A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists.
Expert Opin. Drug Discov., 3(10), 1155-1166 (2008)
Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura & Nobutaka Fujii
Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing.
Perspec. Medicin. Chem., 2, 1-9 (2008)
Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Shinya Oishi & Nobutaka Fujii
Therapeutic Potential of the Chemokine Receptor CXCR4 Antagonists as Multi-functional Agents.
Biopolymers: Peptide Science, 88(2), 279-289 (2007)
Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii
Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis.
Lett. Drug Design Discovery, 4, 20-26 (2007)
Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno & Nobutaka Fujii
Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-scaffolds towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
Curr. Med. Chem., 14 (1), 93-102 (2007)
Hirokazu Tamamura, Hiroshi Tsutsumi & Nobutaka Fujii
The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases.
Mini-Rev. Med. Chem., 6 (9), 109-120 (2006)
Hirokazu Tamamura & Hiroshi Tsutsumi
Specific Probes for Chemokine Receptors.
Chem. Biol., 13, 8-10 (2006)
Hirokazu Tamamura & Nobutaka Fujii
The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
Expert Opin. Ther. Targets, 9 (6),1267-1282 (2005)
Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides.
Curr. HIV Res., 3 (4), 289 – 301 (2005)

和文総説

玉村啓和
「HIVの研究を基盤とした抗SARS-CoV-2剤の創製」
MEDCHEM NEWS（日本薬学会医薬化学部会　東京）、33巻、4号、187-192、2023年
玉村啓和
「創薬を先導する中分子ペプチド」
月刊「細胞」（株式会社　ニューサイエンス社　東京）、55巻、9号、660-661、2023年
小早川拓也、辻耕平、玉村啓和
「ペプチドミメティックを活用した中分子型創薬リードの創製」
「月刊バイオインダストリー」特集“ペプチド医薬の最新動向～広い観点からのペプチド創薬科学～” 「監修　木曽良明」（株式会社　シーエムシー出版　東京）、39巻、5号、69-84、2022年
野村渉、玉村啓和
「HIV-1阻害剤・腫瘍認識プローブとしてのケモカイン受容体リガンド」
「月刊バイオインダストリー」特集“ペプチド医薬の最新動向～広い観点からのペプチド創薬科学～” 「監修　木曽良明」（株式会社　シーエムシー出版　東京）、39巻、5号、15-25、2022年
玉村啓和、小早川拓也、辻耕平
「環状ペプチドで標的細胞へターゲティングする」
「Drug Delivery System」特集“中分子創薬とDDS”（日本DDS学会　東京）、35巻、3号、170-180、2020年
野村渉、玉村啓和
「細胞内タンパク質を可視化するタグ—蛍光プローブシステム」
「生化学」みにれびゅう（日本生化学会　東京）、89巻、1号、頁1-6、2017年
大橋南美、玉村啓和
「ペプチドミメティックを活用した中分子創薬の研究」
化学工業　特集「ペプチド化学の最前線(I)」（化学工業社　川崎）、67巻 10号頁9-17、2016年
玉村啓和
「中分子創薬の可能性―ペプチドを創薬へと展開するー」
現代化学（株式会社　東京化学同人）、6月号 543号頁47-51、2016年
野村渉、玉村啓和
「多価型CXCR4リガンドの創製とがん細胞イメージング・検出」
医学のあゆみ　第5土曜特集「GPCR研究の最前線2016」（医歯薬出版株式会社　東京）、256巻 5号頁430-437、2016年
野村渉、玉村啓和
「ターゲットタンパク質を特異的に認識するプローブ」
「化学工業」特集「ペプチド化学の新潮流(I)」（化学工業社　川崎）、65(11)巻頁8～14、2014年
玉村啓和
「ペプチドミメティックスを活用した抗HIV剤の創製」
「MEDCHEM NEWS」（日本薬学会医薬化学部会）、24(1)巻頁14～19、2014年
玉村啓和
「ケミカルバイオロジーを基盤とした抗HIV剤の創製」
「薬学雑誌」（日本薬学会）、131(1)巻頁69～78、2012年
野村渉、田中智博、相川春夫、玉村啓和
「多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用」
pp267-273．最新ペプチド合成技術とその創薬研究への応用．株式会社　メディカルドゥ．2012
鳴海哲夫、Jeffrey W. Bode
「α-ケト酸とヒドロキシアミンの化学選択的なライゲーション反応によるペプチド合成」
pp68-75．最新ペプチド合成技術とその創薬研究への応用．株式会社　メディカルドゥ．2012
鳴海哲夫、玉村啓和
「ペプチドミメティックによる創薬研究」
「生化学」特集号「ペプチド科学と生化学の接点」（日本生化学会　東京）、第82巻6号　頁515－523、2010年
野村渉、増田朱美、玉村啓和
「エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製」
「生化学」ミニレビュウ（日本生化学会　東京）、第82巻5号　頁393－397、2010年
橋本知恵、玉村啓和
「タンパク質半合成技術を用いたプロテインスプライシング機構の律速段階を実証した」
「ケミカルバイオロジー」（日本ケミカルバイオロジー学会　東京）、第3巻2号　頁15、2010年
玉村啓和
「種々の作用点をターゲットとした抗HIV剤の創製」
日本エイズ学会誌　（日本エイズ学会）、11巻、2号、頁100-101、2009年
玉村啓和
「PK-Cを標的としたdiacylglycerolの環化誘導体の創製」
ファルマシア　最前線（日本薬学会）、42巻、5号、頁431-435、2006年
玉村啓和
「抗ウイルス薬・抗AIDS (HIV)薬」
BIO Clinica（北隆館　東京）、21巻、3号、頁224-230、2006年
藤井信孝、大高章、玉村啓和
「ケミカルプロテオミクスによる創薬基盤の革新―情報から制御へ」
細胞工学　特集　飛躍するケミカルバイオロジー: 化学から生命現象を明らかに　(秀潤社　東京）、24巻、11号、頁1181-1186、2005年

オピニオン

玉村啓和
「明日の創薬を先導する中分子「ペプチド」」
ファルマシア　オピニオン（日本薬学会　東京）、57巻、9号、791、2021年

総説の編集

玉村啓和
「中分子ペプチドが拓く明日の創薬」
月刊「細胞」（株式会社　ニューサイエンス社　東京）、55巻、9号、2023年
Hirokazu Tamamura (Special Issue Editor)
Molecules “Special Issue “Peptide-Lead Drug Discovery”
Closed Jan 31, 2020.