メディシナルケミストリー分野　　大学院修士課程　医歯理工保健学専攻　　大学院博士課程　生命理工医療科学専攻

玉村 啓和

略歴

tamamura玉村　啓和（たまむら　ひろかず）

Hirokazu Tamamura, Ph.D.

東京科学大学　総合研究院
生体材料工学研究所　メディシナルケミストリー分野
副学長／副研究院補佐／教授
博士（薬学）（京都大学）

〒101-0062 東京都千代田区神田駿河台 2-3-10
Tel: (03)5280-8036
Fax: (03)5280-8039
e-mail: tamamura.mr（ここに@をいれてください）tmd.ac.jp

生年月日

1964年7月24日

学歴・職歴・資格

1988年　京都大学薬学部卒業
1989年　京都大学大学院薬学研究科　修士課程　中退
1989-1997年　京都大学薬学部　助手
1997-2005年　京都大学大学院薬学研究科　講師、助教授
この間、
1999-2000年　米国国立がん研究所(National Cancer Institute/NIH)　博士研究員
2005年　東京医科歯科大学生体材料工学研究所　教授
2024年10月　東京工業大学との統合により、東京科学大学総合研究院生体材料工学研究所
副学長、副研究院長補佐、教授

専門

ペプチド・タンパク質化学、創薬化学、ケミカルバイオロジー
ペプチドミメティックを活用した中分子創薬、HIVやコロナウイルス等を対象とした抗ウイルス剤の創製に力を入れている。大学院生(1年しか在席していないが)の時から、アカデミックな創薬化学を基盤としながら、医薬品を開発したいと考えており、2023年にAphexdaTMがFDAより承認された。

所属学会

日本ケミカルバイオロジー研究会、日本薬学会、日本ペプチド学会、アメリカ化学会、日本エイズ学会、日本化学会、有機合成化学協会

受賞歴

  1. 2001年　日本薬学会奨励賞
  2. 1998年　第７回日本薬学会医薬化学部会年会ポスター賞
  3. 1998年　日本ペプチド学会奨励賞

List of publications of Hirokazu Tamamura, Ph. D.

  1. Kouki Shinohara, Takuya Kobayakawa, Kohei Tsuji, Yuki Takamatsu, Hiroaki Mitsuya & Hirokazu Tamamura
    Naphthalen-1-ylethanamine–containing small molecule inhibitors of the papain-like protease of SARS-CoV-2.
    Eur. J. Med. Chem., 280, 116963(article number) available online: Oct 18 (2024). doi: 10.1016/j.ejmech.2024.116963 (Science Tokyo press release)
  2. Shin-ichiro Hattori, Haydar Bulut, Hironori Hayashi, Naoki Kishimoto, Nobutoki Takamune, Kazuya Hasegawa, Yuri Furusawa, Seiya Yamayoshi, Kazutaka Murayama, Hirokazu Tamamura, Mi Li, Alexander Wlodawer, Yoshihiro Kawaoka, Shogo Misumi & Hiroaki Mitsuya
    Structural and virologic mechanism of the emergence of resistance to Mpro inhibitors in SARS-CoV-2.
    Proc. Natl. Acad. Sci. USA, doi.org/10.1073/pnas.2404175121
  3. Kohei Tsuji, Hirokazu Tamamura & Terrence R. Burke, Jr.Application of a Fluorescence Recovery-based Polo-like Kinase 1 Binding Assay to Polo-like Kinase 2 and Polo-like Kinase 3.
    Biol. Pharm. Bull., 47 (7), 1282-1287 (2024). doi.org/10.1248/bpb.b24-00189 (Featured Article)
  4. Kohei Tsuji, Hirokazu Tamamura & Terrence R. Burke, Jr.Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component.
    RSC Chem. Biol., Online Publication Date: Jun 4 (2024). doi.org/10.1039/ d4cb00031e (Inside Front Cover, TMDU press release)
  5. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kiyomi Nigorikawa, Peter Bolah, Airi Noborio, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Wataru Nomura, Hiroaki Mitsuya, Kenji Maeda & Hirokazu TamamuraDiscovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents
    ACS Infect. Dis., 10 (6), 2250-2261 (2024). doi.org/10.1021/acsinfecdis.4c00194 (Supplementary Journal Cover, TMDU press release)
  6. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Peter Bolah, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu TamamuraEffect of two-photon excitation to 8-azacoumarin derivatives as photolabile protecting groups
    Chem. Pharm. Bull., 72 (3), 311-312 (2024). doi.org/10.1248/cpb.c24-00013　(Featured Article)
  7. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Sayaka Boku, Masaki Kurakami, Masayuki Fujino, Takahiro Ishii, Yutaro Miura, Soshi Nishimura, Kouki Shinohara, Kenichi Yamamoto, Peter Bolah, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu TamamuraDevelopment of small-molecule anti-HIV-1 agents targeting HIV-1 capsid proteins.
    Chem. Pharm. Bull., 72 (1), 41-47 (2024). doi.org/10.1248/cpb.c23-00618
  8. Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
    Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement.
    Chem. Pharm. Bull., 71, 879-886 (2023).
  9. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya & Hirokazu Tamamura
    Structure–Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moietie.
    J. Med. Chem., 66, 13516-13529 (2023). doi.org/10.1021/acs.jmedchem.3c00777 (TMDU press release)
  10. Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka & Hirokazu Tamamura
    Development of Anti-HBV Agents Targeting HBV Capsid Proteins.
    RSC. Med. Chem., 14, 1973-1980 (2023). doi.org/10.1039/d3md00258f (TMDU press release) (Front Cover)
  11. Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda & Hirokazu Tamamura
    Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity.
    Eur. J. Med. Chem., 256, 115449(article number) published: Aug 05 (2023). doi: 10.1016/j.ejmech.2023.115449 (TMDU press release, TMDU Int’l press release)
  12. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki & Hirokazu Tamamura
    Dimerized Fusion Inhibitor Peptides Targeting the HR1-HR2 Interaction of SARS-CoV-2.
    RSC Adv., 13, 8779-8793 (2023). doi: 10.1039/d2ra07356k
  13. Nobuyo Higashi-Kuwata, Kohei Tsuji, Hironori Hayashi, Haydar Bulut, Maki Kiso, Masaki Imai, Hiromi Ogata-Aoki, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Nobutoki Takamune, Naoki Kishimoto, Shin-ichiro Hattori, Debananda Das, Yukari Uemura, Yosuke Shimizu, Manabu Aoki, Kazuya Hasegawa, Satoshi Suzuki, Akie Nishiyama, Junji Saruwatari, Yukiko Shimizu, Yoshikazu Sukenaga, Yuki Takamatsu, Kiyoto Tsuchiya, Kenji Maeda, Kazuhisa Yoshimura, Shun Iida, Seiya Ozono, Tadaki Suzuki, Tadashi Okamura, Shogo Misumi, Yoshihiro Kawaoka, Hirokazu Tamamura & Hiroaki Mitsuya
    Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature Commun., 14, 1076(article number) (2023). doi: 10.1038/s41467-023-36729-0
  14. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Takato Onishi, Sayaka Boku, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Yuki Kishihara, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
    Low-molecular-weight Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins.
    RSC Adv., 13, 2156-2167 (2023). doi: 10.1039/d2ra06837k
  15. Kanako Matsuura, Mizuki Yamaura, Hiromi Sakawaki, Ai Himeno, Yalcin Pisil, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Shuzo Matsushita & Tomoyuki MiuraSensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C.
    Virology, 578, 171-179 (2023). doi.org/10.1016/j.virol.2022.12.004
  16. Haruki Kitamura, Sayaka Sukegawa, Kouki Matsuda, Kousuke Tanimoto, Takuya Kobayakawa, Kazuho Takahashi, Hirokazu Tamamura, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Kenji Maeda & Hiroaki Takeuchi
    4-Phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells.
    Biochem. Biophys. Res. Commun., 641, 139-147 (2023). doi.org/10.1016/j.bbrc.2022.12.024
  17. Kaho Matsumoto, Takeo Kuwata, William Tolbert, Jonathan Richard, Shilei Ding, Jérémie Prévost, Shokichi Takahama, George Judicate, Takamasa Ueno, Hirotomo Nakata, Takuya Kobayakawa, Kohei Tsuji, Hirokazu Tamamura, Amos Smith III, Marzena Pazgier, Andrés Finzi & Shuzo Matsushita
    Characterization of a novel CD4 mimetic compound YIR-821 against HIV-1 clinical isolates.
    J. Virol., 97 (1), e01638-22 (2023). doi.org/10.1128/jvi.01638-22
  18. Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors.
    Bioorg. Med. Chem., 76, 117083(article number) (2022). doi.org: 10.1016/j.bmc.2022.117083
  19. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya & Hirokazu Tamamura
    Potent and Biostable Inhibitors of the Main Protease of SARS-CoV-2.
    iScience, 25 (11), 105365(article number) published: Nov 01 (2022). doi.org/10.1016/j.isci.2022.105365 (TMDU press release, TMDU Int’l press release)
  20. Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinovd & Terrence R. Burke, Jr.
    Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1.
    RSC Chemical Biology, 3 (9), 1111-1120 (2022). doi: 10.1039/D2CB00153E (Back Cover picture)
  21. Kohei Tsuji, Takuya Kobayakawa, Kiju Konno, Ami Masuda, Kohei Takahashi, Nami Ohashi, Kazuhisa Yoshimura, Takeo Kuwata, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Exploratory Studies on Soluble Small Molecule CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 56, 116616(article number) (2022). doi.org: 10.1016/j.bmc.2022.116616 (Cover picture)
  22. Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, & Hirokazu Tamamura
    Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-Methoxynaphthalene-labeled 1,2-Diacylglycerol-lactones
    Org. Biomol. Chem., 19(38), 8264-8271 (2021). doi: 10.1039/d1ob00814e (Inside Front Cover)
  23. Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji & Hirokazu Tamamura
    Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application
    J. Org. Chem., 86(7), 5091-5101 (2021). doi.org: 10.1021/acs.joc.0c03019 (TMDU & TOYAKU press release)
  24. Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda
    A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells with a Combination of Latency-reversing Agents Containing DAG-lactone PKC Activators
    Frontiers in Microbiology, 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021.
  25. Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masahi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura & Shiroh Futaki
    Discovery of a Macropinocytosis-inducing Peptide Potentiated by Medium-mediated Intramolecular Disulfide Formation
    Angew. Chem., Int. Ed., 60(21), 11928-11936 (2021). doi: 10.1002/anie.202016754
  26. Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura
    Small-molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins.
    Biomolecules,  11, 208 (2021). https://doi.org/10.3390/biom11020208 (TMDU & AMED press release)
  27. Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
    Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors.
    J. Med. Chem., 64(3), 1481-1496 (2021). doi.org: 10.1021/acs.jmedchem.0c01153 (Supplementary Journal Cover, TMDU & AMED press release)
  28. Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Kofi Baffour-Awuah Owusu, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Potent Leads Based on CA-19L, an Anti-HIV Active HIV-1 Capsid Fragment.
    Bioorg. Med. Chem., 30, 115923 (2021). doi.org: 10.1016/j.bmc.2020.115923 (Cover picture)
  29. Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
    A Cell Cycle-dependent CRISPR-Cas9 Activation System Based on an Anti-CRISPR Protein Shows Improved Genome Editing Accuracy.
    Communications Biology, 3, 1-10 (2020). doi: 10.1038/s42003-020-01340-2
  30. Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami & Hirokazu Tamamura
    Bivalent HIV-1 Fusion Inhibitors Based on Peptidomimetics.
    Bioorg. Med. Chem., 28(24), 115812 (2020). doi.org: 10.1016/j.bmc.2020.115812
  31. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Synthesis of Hydrophilic Caged DAG-lactones for Chemical Biology Applications.
    Org. Biomol. Chem., 18, 4217-4223 (2020). doi: 10.1039/d0ob00807a
  32. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Exploratory Studies on CA-15L, an Anti-HIV Active HIV-1 Capsid Fragment.
    Bioorg. Med. Chem., 28(11), 115488 (2020). doi.org: 10.1016/j.bmc.2020.115488
  33. Daisuke Matsumoto, Hirokazu Tamamura & Wataru Nomura
    TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases.
    Biochemistry, 59(2), 197-204 (2020). doi: 10.1021/acs.biochem.9b00798
  34. Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura & Shuzo Matsushita
    Synergistic Inhibition of Cell-to-cell HIV-1 Infection by Combinations of Single Chain Variable Fragments and Fusion Inhibitors.
    Biochem Biophys Rep., 20, (2019). Sep 21; doi: 10.1016/j.bbrep.2019.100687. eCollection 2019 Dec.
  35. Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    C34 Dimeric Derivatives Utilizing Disulfide Bridges as Novel HIV-1 Fusion Inhibitors.
    ChemBioChem: Special Issue dedicated to the 10th IPS in Kyoto, 20(16) 2101-2108 (2019). doi: 10.1002/cbic.201900187 (Cover picture)
  36. Maxwell M. Sakyiamah, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
    Development of a NanoBRET-based Sensitive Screening Method for CXCR4 Ligands.
    Bioconjugate Chem., 30(5), 1442-1450 (2019). doi: 10.1021/acs.bioconjchem.9b00182
  37. Maxwell M. Sakyiamah, Takuya Kobayakawa, Masayuki Fujino, Makoto Konno, Tetsuo Narumi, Tomohiro Tanaka, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Design, Synthesis and Biological Evaluation of Low Molecular Weight CXCR4 Ligands.
    Bioorg. Med. Chem.: Special Issue entitled “Strategic Basic Molecular Medicinal Chemistry,” 27(6), 1130-1138 (2019). doi.org/10.1016/j.bmc.2019.02.013
  38. Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada & Hirokazu Tamamura
    Soluble-type Small-molecule CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem. Lett., 29(5), 719-723 (2019). doi.org/10.1016/j.bmcl.2019.01.011
  39. Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-ichiro Hattori, Wataru Nomura, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya & Kenji Maeda
    Benzolactam-Related Compounds Promote Apoptosis Via Protein Kinase C-Induced HIV Latency Reversal.
    J. Biol. Chem., 294(1), 116-129 (2019). doi: 10.1074/jbc.RA118.005798.
  40. Akinobu Z. Suzuki, Ryota Sekine, Shiori Takeda, Ryosuke Aikawa, Yukiko Shiraishi, Tomomi Hamaguchi, Hiroyuki Okuno, Hirokazu Tamamura & Toshiaki Furuta
    A Clickable Caging Group as a New Platform for Modular Caged Compounds with Improved Photochemical Properties.
    Chem. Comm., 55, 451-454 (2019). doi: 10.1039/c8cc07981a
  41. Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa & Hirokazu Tamamura
    Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors.
    Biochemistry, 57(45), 6452-6459 (2018). doi: 10.1021/acs.biochem.8b00741
  42. Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada & Hirokazu Tamamura
    Flexibility of Small Molecular CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 26(21), 5664-5671 (2018). doi.org: 10.1016/j.bmc.2018.10.011
  43. Kei Toyama, Takuya Kobayakawa, Wataru Nomura & Hirokazu Tamamura
    Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
    Chem. Pharm. Bull., 66(11), 1083-1089 (2018).
  44. Kei Toyama, Wataru Nomura, Takuya Kobayakawa & Hirokazu Tamamura
    Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.
    Bioconjugate Chem., 29(6), 2050-2057 (2018). doi: 10.1021/acs.bioconjchem.8b00250
  45. Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu & Hirokazu Tamamura
    Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application.
    ACS Med. Chem. Lett., 9(1), 6-10 (2018). doi: 10.1021/acsmedchemlett.7b00234
  46. Nami Ohashi, Ryosuke Kobayashi, Wataru Nomura, Takuya Kobayakawa, Agnes Czikora, Brienna K Herold, Nancy E. Lewin, Peter M. Blumberg& Hirokazu Tamamura
    Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
    Bioconjugate Chem., 28(8), 2135-2144 (2017)
  47. Takuya Kobayakawa & Hirokazu Tamamura
    Stereoselective Synthesis of Xaa-Yaa Type (Z)-Chloroalkene Dipeptide Isosteres via Efficient Utilization of Organocopper Reagents Mediated Allylic Alkylation.
    Tetrahedron, 73(30), 4464-4471 (2017)
  48. Kazuya Kobayashi, Takaaki Mizuguchi, Yasunao Hattori, Naho Ohara, Ryunosuke Ninomiya, Mika Iida, Honami Ooe, Yukako Yamazaki, Minami Takata, Hirokazu Tamamura & Kenichi Akaji
    Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor.
    J. Pept. Sci., 23(7-8), 581-586 (2017)
  49. Hikaru Takano, Tetsuo Narumi, Wataru Nomura, and Hirokazu Tamamura
    Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization.
    J. Org. Chem., 82(5), 2739-2744 (2017)
  50. Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
    Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells.
    J. Pept. Sci., 23(7-8), 574-580 (2017)
  51. Takaaki Mizuguchi, Nami Ohashi, Daichi Matsumoto, Chie Hashimoto, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Development of Anti-HIV Peptides Based on a Viral Capsid Protein.
    Biopolymers: Peptide Science, 2017 Jan;108(1). doi: 10.1002/bip.22920 (2017)
  52. Tomofumi Nakamura, Joseph R. Campbell, Amber R. Moore, Sachiko Otsu, Haruo Aikawa, Hirokazu Tamamura & Hiroaki Mitsuya
    Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization.
    J. Virol. Methods, 236, 196-206 (2016)
  53. Takuya Kobayakawa & Hirokazu Tamamura
    Efficient Synthesis of Xaa-Gly Type (Z)-Chloroalkene Dipeptide Isosteres via Organocuprate Mediated Reduction.
    Tetrahedron, 72(32), 4968-4971 (2016)
  54. Kei Toyama, Takaaki Mizuguchi, Wataru Nomura & Hirokazu Tamamura
    Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization.
    Bioorg. Med. Chem., 24(16), 3406-3412 (2016)
  55. Kenichi Hiramatsu & Hirokazu Tamamura
    A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst.
    Eur. J. Org. Chem., 2016(21), 3491-3494 (2016)
  56. Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura
    Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines.
    Biopolymers: Peptide Science, 106(4), 622-628 (2016)
  57. Aisha Abduelmula, Ruijin Huang, Qin Pu, Hirokazu Tamamura, Gabriela Morosan-Puopolo & Beate Brand-Saberi
    SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite.
    Int. J. Dev. Biol., 60(1-2-3), 29-38 (2016)
  58. Nami Ohashi, Shigeyoshi Harada, Takaaki Mizuguchi, Yu Irahara, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura　& Hirokazu Tamamura
    Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.
    ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions, 11(8), 940-946 (2016)
  59. Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori; Yu Irahara; Yuko Yamada; Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura & Hirokazu Tamamura
    A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor.
    Bioorg. Med. Chem. Lett., 26(2), 397-400 (2016)
  60. Hikaru Takano, Tetsuo, Narumi, Wataru Nomura, Toshiaki Furuta & Hirokazu Tamamura
    Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group.
    Org. Lett., 17(21), 5372-5375 (2015)
  61. Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe, Takaaki Mizuguchi & Hirokazu Tamamura
    Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands.
    Bioorg. Med. Chem., 23(21), 6967-6973 (2015)
  62. Wataru Nomura, Taisuke Koseki, Nami Ohashi, Takaaki Mizuguchi & Hirokazu Tamamura
    Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression.
    Org. Biomol. Chem., 13(32), 8734-8739 (2015)
  63. Takaaki Mizuguchi, Nami Ohashi, Wataru Nomura, Mao Komoriya, Chie Hashimoto, Naoki Yamamoto, Tsutomu Murakami, & Hirokazu Tamamura
    Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins.
    Bioorg. Med. Chem., 23(15), 4423-4427 (2015)
  64. Wataru Nomura, Nami Ohashi, Atsumi Mori & Hirokazu Tamamura
    An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides.
    Bioconjugate Chem., 26(6), 1080-1085 (2015)
  65. Takuya Kobayakawa, Tetsuo Narumi & Hirokazu Tamamura
    Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres.
    Org. Lett., 17(10), 2302-2305 (2015)
  66. Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura
    Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer.
    Chem. Pharm. Bull.,62(10), 1019-1025 (2014)
  67. Maryna Masyuk, Aisha Abduelmula, Gabriela Morosan-Puopolo, Veysel Odemis, Rizwan Rehimi, Nargis Khalida, Faisal Yusuf, Jurgen Engele, Hirokazu Tamamura, Carsten Theiss & Beate Brand-Saberi
    Retrograde Migration of Pectoral Girdle Muscle Precursors Depends on CXCR4/SDF-1 Signaling.
    Histochem. Cell. Biol.,142(5), 473-488 (2014)
  68. Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura,Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker.
    Tetrahedron, 70(34), 5122-5127 (2014)
  69. Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura
    Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups.
    Tetrahedron, 70(29), 4400-4404 (2014)
  70. Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura,Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka
    Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins.
    Org. Biomol. Chem., 12(23), 3821-3826 (2014)
  71. Tetsuo Narumi, Seiji Tsuzuki & Hirokazu Tamamura
    Imidazolium Salt-Catalyzed Friedel-Crafts-Type Conjugate Addition of Indoles: Analysis of Indole/Imidazolium Complex by High Level ab Initio Calculations.
    Asian J. Org. Chem., 3(4), 497-503 (2014)
  72. Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura
    Isostere-Based Design of 8-Azacoumarin-Type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls.
    Org. Lett., 16(4), 1184-1187 (2014)
  73. Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura
    Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C.
    Biopolymers: Peptide Science, 100(6), 613-620 (2013)
  74. Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura
    A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics.
    Bioorg. Med. Chem., 21(24), 7884-7889 (2013)
  75. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies.
    Bioorg. Med. Chem., 21(22), 6878-6885 (2013)
  76. Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi
    Generation of a Replication-competent Simian-human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic.
    J. Gen.Virol., 94(12), 2710-2716 (2013)
  77. Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4.
    ChemMedChem, 8(10), 1668-1672 (2013)
  78. Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura
    Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products.
    ACS Chem. Biol., 8(10), 2235-2244 (2013)
  79. Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors.
    Bioorg. Med. Chem., 21(15), 4452-4458 (2013)
  80. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.
    Bioorg. Med. Chem., 21(9), 2518-2526 (2013)
  81. Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Low Molecular Weight CXCR4 Ligands with Variable Spacers.
    ChemMedChem, 8(1), 118-124 (2013)
  82. Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura
    Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation.
    Org. Lett., 14, 4490-4493 (2012)
  83. Tetsuo Narumi, Tomohiro Tanaka, Chie Hashimoto, Wataru Nomura, Haruo Aikawa, Akira Sohma, Kyoko Itotani, Miyako Kawamata, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Pharmacophore-based small molecule CXCR4 ligands.
    Bioorg. Med. Chem. Lett., 22, 4169-4172 (2012)
  84. Chie Hashimoto, Wataru Nomura, Aki Ohya, Emiko Urano, Kosuke Miyauchi, Tetsuo Narumi, Haruo Aikawa, Jun A. Komano, Naoki Yamamoto & Hirokazu Tamamura
    Evaluation of a Synthetic C34 Trimer of HIV-1 gp41 as AIDS Vaccines.
    Bioorg. Med. Chem., 20, 3287-3291 (2012)
  85. Wataru Nomura, Akemi Masuda, Kenji Ohba, Arisa Urabe, Nobutoshi Ito, Akihide Ryo, Naoki Yamamoto &Hirokazu Tamamura
    Effects of DNA Binding of Zinc Finger and Linkers for Domain Fusion on Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System.
    Biochemistry, 51, 1510-1517(2012)
  86. Wataru Nomura, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun Komano, Naoki Yamamoto & Hirokazu Tamamura
    A Synthetic C34 Trimer of HIV-1 gp41 Shows Significant Increase of Inhibition Potency.
    ChemMedChem, 7, 205-208 (2012)
  87. Tetsuo Narumi, Mao Komoriya, Chie Hashimoto, Honggui Wu, Wataru Nomura, Shintaro Suzuki, Tomohiro Tanaka, Joe Chiba, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura
    Conjugation of Cell-penetrating Peptides Leads to Identification of Anti-HIV Peptides from Matrix Proteins.
    Bioorg. Med. Chem., 20, 1468-1474 (2012)
  88. Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Wataru Nomura, Shuzo Matsushita &Hirokazu Tamamura
    Small Molecular CD4 Mimics as HIV Entry Inhibitors.
    Bioorg. Med. Chem., 19, 6735-6742 (2011)
  89. Chie Hashimoto, Tomohiro Tanaka, Tetsuo Narumi, Wataru Nomura & Hirokazu Tamamura
    The Success and Failures of HIV Drug Discovery.
    Expert Opin. Drug Discov., 6, 1067-1090 (2011)
  90. Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii & Mitsuo Kaku
    The Increase in Surface CXCR4 Expression on　Lung Extravascular Neutrophils and its Effects on Neutrophils During Endotoxin-Induced Lung Injury.
    Cell Mol. Immunol., 8, 305-314 (2011)
  91. Changshui Xu, Jianuo Liu, Lina Chen, Shangdong Liang, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    HIV-1 gp120 Enhances Outward Potassium Current via CXCR4 and cAMP-Dependent Protein Kinase a Signaling in Cultured Rat Microglia.
    Glia., 59, 997-1007 (2011)
  92. Wataru Nomura, Nami Ohashi, Yoshiaki Okuda, Tetsuo Narumi, Teikichi Ikura, Nobutoshi Ito & Hirokazu Tamamura
    Fluorescence-Quenching Screening of Protein Kinase C Ligands with an Environmentally Sensitive Fluorophore.
    Bioconjugate Chem., 22, 923-930 (2011)
  93. Tomohiro Tanaka, Tetsuo Narumi, Taro Ozaki, Akira Sohma, Nami Ohashi, Chie Hashimoto, Kyoko Itotani, Wataru Nomura, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Azamacrocyclic-metal Complexes as CXCR4 Antagonists.
    ChemMedChem, 6, 834-839 (2011)
  94. Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino, Wataru Nomura & Hirokazu Tamamura
    Intense Blue Fluorescence in a Leucine Zipper Assembly.
    ChemBioChem, 12, 691-694 (2011)
  95. Nami Ohashi, Wataru Nomura, Tetsuo Narumi, Nancy E. Lewin, Kyoko Itotani, Peter M. Blumberg & Hirokazu Tamamura
    Fluorescent-responsive Synthetic C1b Domains of Protein Kinase Cδ as Reporters of Specific High Affinity Ligand Binding.
    Bioconjugate Chem., 22, 82-87 (2011)
  96. Wataru Nomura, Tetsuo Narumi, Nami Ohashi, Yuki Serizawa, Nancy E. Lewin, Peter M. Blumberg, Toshiaki Furuta & Hirokazu Tamamura
    Synthetic Caged DAG-lactones for Photochemically-controlled Activation of Protein Kinase C.
    ChemBioChem, 12, 535-539 (2011)
  97. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Akemi Masuda & Hirokazu Tamamura
    Bivalent Ligands of CXCR4 with Rigid Linkers for Elucidation of Dimerization State in Cells
    J. Am. Chem. Soc.(Commun.),132, 15899-15901 (2010)
  98. Tetsuo Narumi, Chihiro Ochiai, Kazuhisa Yoshimura, Shigeyoshi Harada, Tomohiro Tanaka, Wataru Nomura, Hiroshi Arai, Taro Ozaki, Nami Ohashi, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the HIV Entry Mechanism and their Hybrid Molecules with a CXCR4 Antagonist
    Bioorg. Med. Chem. Lett., 20, 5853-5858 (2010)
  99. Shintaro Suzuki, Kasthuraiah Maddali, Chie Hashimoto, Emiko Urano, Nami Ohashi, Tomohiro Tanaka, Taro Ozaki, Hiroshi Arai, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Yves Pommier, Jun A. Komano & Hirokazu Tamamura
    Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies.
    Bioorg. Med. Chem., 18, 6771-6775 (2010)
  100. Shintaro Suzuki, Emiko Urano, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Kasthuraiah Maddali, Yan Han, Makiko Hamatake, Kosuke Miyauchi, Yves Pommier, John A. Beutler, Wataru Sugiura, Hideyoshi Fuji, Tyuji Hoshino, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Jun A. Komano & Hirokazu Tamamura
    Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products.
    J. Med. Chem., 53(14), 5356-5360 (2010)
  101. Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai,Hirokazu Tamamura & Shuzo Matsushita
    Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds.
    J. Virol., 84(15), 7558-7568 (2010)
  102. Toru Aoki, Saki Shimizu, Emiko Urano, Yuko Futahashi, Makiko Hamatake, Hirokazu Tamamura, Kazuo Terashima, Tsutomu Murakami, Naoki Yamamoto & Jun Komano
    Improvement of Lentiviral Vector-mediated Gene Transduction by Genetic Engineering of the Structural Protein Pr55Gag.
    Gene Ther., 17(9), 1124-1133(2010)
  103. Roberta Melchionna, Anna Di Carlo, Roberta De Mori, Claudia Cappuzzello, Laura Barberi, Antonio Musar?, Chiara Cencioni, Nobutaka Fujii, Hirokazu Tamamura, Marco Crescenzi, Maurizio C. Capogrossi, Monica Napolitano & Antonia Germani
    Induction of Myogenic Differentiation by SDF-1 via CXCR4 and CXCR7 Receptors.
    Muscle Nerve., 41(6), 828-835 (2010)
  104. Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi & Hirokazu Tamamura
    Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins.
    Biopolymers: Peptide Science, 94, 843-852 (2010)
  105. Toru Nakahara, Wataru Nomura, Kenji Ohba, Aki Ohya, Tomohiro Tanaka, Chie Hashimoto, Tetsuo Narumi, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura
    Remodeling of Dynamic Structures of HIV-1 Envelope Proteins Leads to Synthetic Antigen Molecules Inducing Neutralizing Antibodies.
    Bioconjugate Chem., 21(4), 709-714 (2010)
  106. Yuko Yamada, Chihiro Ochiai, Kazuhisa Yoshimura, Tomohiro Tanaka, Nami Ohashi, Tetsuo Narumi, Wataru Nomura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura
    CD4 Mimics Targeting the Mechanism of HIV.
    Bioorg. Med. Chem. Lett., 20, 354-358 (2010)
  107. Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi & Hirokazu Tamamura
    Fluorogenically Active Leucine Zipper Peptides as New Tag-Probe Pairs for Protein Imaging in Living Cells.
    Angew. Chem., Int. Ed., 48, 9164-9166 (2009)
  108. Tomohiro Tanaka, Wataru Nomura, Tetsuo Narumi, Ai Esaka, Shinya Oishi, Nami Ohashi, Kyoko Itotani, Barry J. Evans, Zi-xuan Wang, Stephen C. Peiper, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study on Artificial CXCR4 Ligands Possessing the Cyclic Pentapeptide Scaffold: The Exploration of Amino Acid Residues of Pentapeptides by Substitutions of Several Aromatic Amino Acids.
    Org. Biomol. Chem., 7, 3805-3809 (2009)
  109. Nami Ohashi, Wataru Nomura, Mai Kato, Tetsuo Narumi, Nancy E. Lewin, Peter M. Blumberg & Hirokazu Tamamura
    Synthesis of Protein Kinase Cδ C1b Domain by Native Chemical Ligation Methodology and Characterization of Its Folding and Ligand Binding.
    J. Pept. Sci., 5(10), 642-646 (2009)
  110. Yuka Inaba, Nobuko Yoshimoto, Yuta Sakamaki, Makoto Nakabayashi, Teikichi Ikura, Hirokazu Tamamura, Nobutoshi Ito, Masato Shimizu & Keiko Yamamoto
    A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor.
    J. Med. Chem., 52(5), 1438-1449 (2009)
  111. Fuminori Mizukoshi, Kenji Baba, Yuko Goto-Koshino, Asuka Setoguchi-Mukai, Yasuhito Fujino, Koichi Ohno,Hirokazu Tamamura, Shinya Oishi, Nobutaka Fujii & Hajime Tsujimoto
    Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus.
    J. Vet. Med. Sci., 71(1), 121-124 (2009)
  112. Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Ai Esaka, Chihiro Ochiai, Jun Sato, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii & Hirokazu Tamamura
    Structure-activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore.
    Org. Biomol. Chem., 6, 4374-4377 (2008)
  113. Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto &Hirokazu Tamamura
    Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening.
    Bioconjugate Chem., 19, 1917-1920 (2008)
  114. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii
    A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists.
    Expert Opin. Drug Discov., 3(10), 1155-1166 (2008)
  115. Hirotomo Nakata, Seth M. Steinberg, Yasuhiro Koh, Kenji Maeda, Yoshikazu Takaoka, Hirokazu Tamamura, Nobutaka Fujii & Hiroaki Mitsuya
    Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs.
    Antimicrob. Agents Chemother., 52(6), 2111-2119 (2008)
  116. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura & Nobutaka Fujii
    Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing.
    Perspec. Medicin.l Chem., 2, 1-9 (2008)
  117. Wouter H. P., Driessen, Nobutaka Fujii, Hirokazu Tamamura & Sean M. Sullivan
    Development of Peptide-targeted Lipoplexes to CXCR4-expressing Rat Glioma Cells and Rat Proliferating Endothelial Cells.
    Mol. Ther., 16(3), 516-524 (2008)
  118. Alexander Kasiyanov, Nobutaka Fujii, Hirokazu Tamamura & Huangui Xiong
    Modulation of Network-driven, GABA-mediated Giant Depolarizing Potentials by SDF-1 in Developing Hippocampus.
    Developmental Neuroscience, 30(4), 285-292 (2008)
  119. Kenji Kabashima, Noriko Shiraishi, Kazunari Sugita, Tomoko Mori, Ayako Onoue, Miwa Kobayashi, Jun-ichi Sakabe, Ryutaro Yoshiki, Hirokazu Tamamura, Nobutaka Fujii, Kayo Inaba & Yoshiki Tokura
    CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells.
    Am. J Pathol., 171(4), 1249-1257 (2007)
  120. Kenji Kabashima, Kazunari Sugita, Noriko Shiraishi, Hirokazu Tamamura, Nobutaka Fujii & Yoshiki Tokura
    CXCR4 Engagement Promotes Dendritic Cell Survival and Maturation.
    Biochem. Biophys. Res. Commun., 361, 1012-1016 (2007)
  121. Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii
    Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics.
    Tetrahedron, 63, 9243-9254 (2007)
  122. Yamina A. Berchiche, Ken Y. Chow, Bernard Lagane, Martin Leduc, Yann Percherancier, Nobutaka Fujii,Hirokazu Tamamura, Fran?oise Bachelerie & Nikolaus Heveker
    Direct Assessment of CXCR4 Mutant Conformations Reveals Complex link between Receptor Structure and Galphai Activation.
    J. Biol. Chem. (Commun.), 282, 5111 – 5115 (2007)
  123. Shiro Kubonishi, Tomoko Kikuchi, Shinya Yamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Toshimitsu Matsui, Mitsune Tanimoto & Yoshio Katayama
    Rapid Hematopoietic Progenitor Mobilization by Sulfated Colominic Acid.
    Biochem. Biophys. Res. Commun., 355 (4), 970-975 (2007)
  124. Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Shinya Oishi & Nobutaka Fujii
    Therapeutic Potential of the Chemokine Receptor CXCR4 Antagonists as Multi-functional Agents.
    Biopolymers: Peptide Science, 88(2), 279-289 (2007)
  125. Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Takanobu Araki, Hirokazu Tamamura, Jerome Cluzeau, Hiroaki Ohno, Shuichi Kusano, Hideki Nakashima, John O. Trent, Stephen C. Peiper & Nobutaka Fujii
    Structure-Activity Relationships of Cyclic Peptide-Based Chemokine Receptor CXCR4 Antagonists: Disclosing the Importance of Side-Chain and Backbone Functionalities.
    J. Med. Chem., 50(2), 192-198 (2007)
  126. Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii
    Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis.
    Lett. Drug Design Discovery, 4, 20-26 (2007)
  127. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno & Nobutaka Fujii
    Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-scaffolds towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Curr. Med. Chem., 14 (1), 93-102 (2007)
  128. Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, Stephen C. Peiper, Kazuo Kitaura, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated Anti-S(N)2 ‘ Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists.
    J. Org. Chem., 71 (10), 3942-3951 (2006)
  129. Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Satoko Mizokami, Kenichi Hiramatsu, Zixuan Wang, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper & Nobutaka Fujii
    Development of a Linear Type of Low Molecular Weight CXCR4 Antagonists Based on T140 Analogs.
    Org. Biomol. Chem., 4, 2354-2357 (2006)
  130. Hirokazu Tamamura, Hiroshi Tsutsumi & Nobutaka Fujii
    The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases.
    Mini-Rev. Med. Chem., 6, 989-995 (2006)
  131. Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi & Nobutaka Fujii
    Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure.
    J. Med. Chem., 49 (11), 3412-3415 (2006)
  132. Eline Menu, Kewal Asosingh, Stefano Indraccolo, Hendrik De Raeve, Ivan Van Riet, Els Van Valckenborgh, Isabelle Vande Broek, Nobutaka Fujii, Hirokazu Tamamura, Ben Van Camp & Karin Vanderkerken
    The Involvement of Stromal Derived Factor 1α in Homing and Progression of Multiple Myeloma in the 5TMM Model.
    Haematologica/the Hematology Journal, 91(5), 605-612 (2006)
  133. Hirofumi Hanaoka, Takahiro Mukai, Hirokazu Tamamura, Tomohiko Mori, Seigo Ishino, Kazuma Ogawa, Yasuhiko Iida, Ryuichiro Doi, Nobutaka Fujii & Hideo Saji
    Development of a In-111-Labeled Peptide Derivative Targeting a Chemokine Receptor, CXCR4, for Imaging Tumors.
    Nucl. Med. Biol., 33 (4), 489-494 (2006)
  134. Alexander Kasyanov, Hirokazu Tamamura, Nobutaka Fujii & Huangui Xiong
    HIV-1 gp120 Enhances Giant Depolarizing Potentials via Chemokine Receptor CXCR4 in Neonatal Rat Hippocampus.
    Eur. J. Neuroscience, 23, 1120-1128 (2006)
  135. Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii
    Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides.
    Tetrahedron, 62, 1416-1424 (2006)
  136. Hirokazu Tamamura & Hiroshi Tsutsumi
    Specific Probes for Chemokine Receptors.
    Chem. Biol., 13, 8-10 (2006)
  137. Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper & Nobutaka Fujii
    Design and Synthesis of Downsized Metastin (45-54) Analogs with Maintenance of High GPR54 Agonistic Activity.
    Bioorg. Med. Chem. Lett., 16(1), 134-137 (2006)
  138. Hirokazu Tamamura & Nobutaka Fujii
    The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis.
    Expert Opin. Ther. Targets, 9 (6),1267-1282 (2005)
  139. Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Structure-activity Relationship Studies on CXCR4 Antagonists Having Cyclic Pentapeptide Scaffolds.
    Org. Biomol. Chem., 3, 4392-4394 (2005)
  140. Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum
    New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion.
    Eur. Urol., 48 (6), 1025-1030 (2005)
  141. Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Photolabile Protection for One-Pot Sequential Native Chemical Ligation.
    ChemBioChem, 6 (11), 1983-1986 (2005)
  142. Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent
    A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools.
    QSAR Comb. Sci., 24 (5), 620-630 (2005)
  143. Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka
    Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2′ Reactions.
    Tetrahedron Lett., 46, 4183-4186 (2005)
  144. Meike Burger, Tanja Hartmann, Myriam Krome, Justyna Rawluk, Hirokazu Tamamura, Nobutaka Fujii, Thomas J. Kipps & Jan A. Burger
    Small Peptide Inhibitors of the CXCR4 Chemokine Receptor (CD184) Antagonize the Activation, Migration and Antiapoptotic Responses of CXCL12 in Chronic Lymphocytic Leukemia B Cells.
    Blood, 106 (5), 1824-1830 (2005)
  145. Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka & Nobutaka Fujii
    Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide-scaffolds.
    J. Med. Chem., 48, 3280-3289 (2005)
  146. Yann Percherancier, Yamina Berchiche, Isabelle Slight, Rudolf Volkmer-Engert, Hirokazu Tamamura, Nobutaka Fujii, Michel Bouvier & Nikolaus Heveker
    Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers.
    J. Biol. Chem., 280, 9895 – 9903 (2005)
  147. Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
    Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides.
    Curr. HIV Res., 3 (4), 289 – 301 (2005)
  148. Andrew C. W. Zannettino, Amanda N. Farrugia, Angela Kortesidis, Jim Manavis, Luen B. To, Sally K. Martin, Peter Diamond, Hirokazu Tamamura, Tsvee Lapidot, Nobutaka Fujii & Stan Gronthos
    Elevated Serum Levels of SDF-1α are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients.
    Cancer Res., 65(5), 1700-1709 (2005)
  149. Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii & Masao Matsuoka
    Mutations Conferring Resistance to HIV-1 Fusion Inhibitors Are Restricted by gp41 and Rev Responsive Element Functions.
    J. Virol., 79, 764-770 (2005)
  150. Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogs of the CXCR4 Antagonist FC131.
    J. Med. Chem., 48, 380-391 (2005)
  151. Erich Piovan, Valeria Tosello, Stefano Indraccolo, Anna Cabrelle, Ilenia Baesso, Livio Trentin, Rita Zamarchi,Hirokazu Tamamura, Nobutaka Fujii, Gianpietro Semenzato, Luigi-Chieco Bianchi & Alberto Amadori
    Chemokine Receptor Expression in EBV-associated Lymphoproliferation in Hu/SCID Mice: Implications for CXCL12/CXCR4 Axis in Lymphoma Generation.
    Blood, 105, 931-939 (2005)
  152. Christopher D. C. Allen, K. Mark Ansel, Caroline Low, Robin Lesley, Hirokazu Tamamura, Nobutaka Fujii & Jason G. Cyster
    Germinal Center Dark and Light Zone Organization Is Mediated by CXCR4 and CXCR5.
    Nat. Immunol., 5, 943-952 (2004)
  153. Hirokazu Tamamura, Dina M. Sigano, Nancy E. Lewin, Megan L. Peach, Marc C. Nicklaus, Peter M. Blumberg & Victor E. Marquez
    Conformationally Constrained Analogues of Diacylglycerol (DAG). 23. Hydrophobic Ligand-Protein Interactions versus Ligand-Lipid Interactions of DAG-Lactones with Protein Kinase C (PK-C).
    J. Med. Chem., 47, 4858-4864 (2004)
  154. Akira Otaka, Satoshi Ueda, Kenji Tomita, Yoshiaki Yano, Hirokazu Tamamura, Katsumi Matsuzaki & Nobutaka Fujii
    Facile Synthesis of Membrane-embedded Peptides Utilizing Lipid Bilayer-assisted Chemical Ligation.
    Chem. Commun., 2004 (15), 1722-1723 (2004)
  155. Hirokazu Tamamura, Miho Fujisawa, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka & Nobutaka Fujii
    Identification of a CXCR4 Antagonist, a T140 Analog, as an Anti-rheumatoid Arthritis Agent.
    FEBS Lett., 569 (1), 99-104 (2004)
  156. Mitsuko Takenaga, Hirokazu Tamamura, Kenichi Hiramatsu, Natsumi Nakamura, Yoko Yamaguchi, Aki Kitagawa, Shinichi Kawai, Hideki Nakashima, Nobutaka Fujii & Rie Igarashi
    A Single Treatment with Microcapsules Containing a CXCR4 Antagonist Suppresses Pulmonary Metastasis of Murine Melanoma.
    Biochem. Biophys. Res. Commun., 320 (1), 226-232 (2004)
  157. Norio Yamamoto, Rongge Yang, Yoshiyuki Yoshinaka, Shinji Amari, Tatsuya Nakano, Jindrich Cinatl, Holger Rabenau, Hans Wilhelm Doerr, Gerhard Hunsmann, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii & Naoki Yamamoto
    HIV Protease Inhibitor Nelfinavir Inhibits Replication of SARS-associated Coronavirus.
    Biochem. Biophys. Res. Commun., 318 (3), 719-725 (2004)
  158. Akira Otaka, Junko Watanabe, Akira Yukimasa, Yoshikazu Sasaki, Hideaki Watanabe, Takayoshi Kinoshita, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii
    SmI2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres.
    J. Org. Chem., 69(5), 1634-1645 (2004)
  159. Hirokazu Tamamura & Nobutaka Fujii
    Two Orthogonal Approaches to Overcome Multi-Drug Resistant HIV-1s: Development of Protease Inhibitors and Entry Inhibitors Based on CXCR4 Antagonists.
    Curr. Drug Targets-Infectious Disorders, 4(2), 103-110 (2004)
  160. Hirokazu Tamamura, Makiko Mizumoto, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Topochemical Exploration of Potent Compounds Using Retro-Enantiomer Libraries of Cyclic Pentapeptides.
    Org. Biomol. Chem., 2, 1255-1257 (2004)
  161. Hui Peng, Yunlong Huang, Jeremy Rose, David Erichsen, Shelley Herek, Nobutaka Fujii, Hirokazu Tamamura& Jialin Zheng
    Stromal Cell-Derived Factor 1-Mediated CXCR4 Signaling in Rat and Human Cortical Neural Progenitor Cells.
    J. Neurosci. Res., 76, 35-50 (2004)
  162. Hirokazu Tamamura, Dina M. Sigano, Nancy E. Lewin, Peter M. Blumberg & Victor E. Marquez
    Conformationally Constrained Analogues of Diacylglycerol. 20. The Search for an Elusive Binding Site on Protein Kinase C (PK-C) through Relocation of the Carbonyl Pharmacophore along the sn-1 Side Chain of DAG-lactones.
    J. Med. Chem., 47, 644-655 (2004)
  163. Tomohiko Mori, Ryuichiro Doi, Masayuki Koizumi, Eiji Toyoda, Daisuke Ito, Kazuhiro Kami, Toshihiko Masui, Koji Fujimoto, Hirokazu Tamamura, Kenichi Hiramatsu, Nobutaka Fujii & Masayuki Imamura
    CXCR4 Antagonist Inhibits Stromal Cell-derived Factor 1-induced Migration and Invasion of Human Pancreatic Cancer.
    Mol. Cancer Ther., 3, 29-37 (2004)
  164. John O. Trent, Zi-xuan Wang, James L. Murray, Wenhai Shao, Hirokazu Tamamura, Nobutaka Fujii & Stephen C. Peiper
    Lipid Bilayer Simulations of CXCR4 with Inverse Agonists and Weak Partial Agonists.
    J. Biol. Chem., 278, 47136-47144 (2003)
  165. Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Satoshi Ueda, Shuichi Kusano, Shigemi Terakubo, Miki Akamatsu, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Enhancement of the T140-based Pharmacophores Leads to the Development of More Potent and Bio-stable CXCR4 Antagonists.
    Org. Biomol. Chem., 1, 3663-3669 (2003)
  166. Hirokazu Tamamura, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Synthesis of Potent CXCR4 Inhibitors Possessing Low Cytotoxicity and Improved Biostability Based on T140 Derivatives.
    Org. Biomol. Chem., 1, 3656-3662 (2003)
  167. Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka & Nobutaka Fujii
    T140 Analogs as CXCR4 Antagonists Identified as Anti-metastatic Agents in the Treatment of Breast Cancer.
    FEBS Lett., 550, 79-83 (2003)
  168. Toshina Oonuma, Masami Morimatsu, Takayuki Nakagawa, Rina Uyama, Nobuo Sasaki, Hirokazu Tamamura, Nobutaka Fujii, Shizu Hashimoto, Hozumi Yamamura & Bunei Syuto
    Role of CXCR4 and SDF-1 in Mammary Tumor Metastasis in the Cat.
    J. Vet. Med. Sci., 65(10), 1069-1073 (2003)
  169. Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, James A. Broach, John O. Trent, Zixuan Wang & Stephen C. Peiper
    Molecular-Size Reduction of a Potent CXCR4-Chemokine Antagonist Using Orthogonal Combination of Conformation- and Sequence-Based Libraries.
    Angew. Chem. Int. Ed., 42(28), 3251-3253 (2003)
  170. Hirokazu Tamamura, Terukazu Kato, Akira Otaka & Nobutaka Fujii
    Synthesis of Potent -Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and Their Structure-Activity Relationship Studies.
    Org. Biomol. Chem., 1(14), 2468-2473 (2003)
  171. Akira Otaka, Akira Yukimasa, Junko Watanabe, Yoshikazu Sasaki, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii
    Application of Samarium Diiodide (SmI2)-induced Reduction of γ-Acetoxy-α,β-enoates with α-Specific Kinetic Electrophilic Trapping for the Synthesis of Amino Acid Derivatives.
    Chem. Commun., 2003(15), 1834-1835 (2003)
  172. Tadashi Yasuda, A. Robin Poole, Makoto Shimizu, Takefumi Nakagawa, Sohel M. Julovi, Hirokazu Tamamura, Nobutaka Fujii & Takashi Nakamura
    Involvement of CD44 in Induction of Matrix Metalloproteinases by a COOH-Terminal Heparin-Binding Fragment of Fibronectin in Human Articular Cartilage in Culture.
    Arthritis Rheum., 48(5), 1271-1280 (2003)
  173. Hirokazu Tamamura, Yasuhiro Koh, Satoshi Ueda, Yoshikazu Sasaki, Tomonori Yamasaki, Manabu Aoki, Kenji Maeda, Yoriko Watai, Hisashi Arikuni, Akira Otaka, Hiroaki Mitsuya & Nobutaka Fujii
    Reduction of Peptide Character of HIV Protease Inhibitors that Exhibit Nanomolar Potency against Multi-drug Resistant HIV-1 Strains.
    J. Med. Chem., 46(9), 1764-1768 (2003)
  174. Nobutaka Fujii, Hideki Nakashima & Hirokazu Tamamura
    The Therapeutic Potential of CXCR4 Antagonists in the Treatment of HIV.
    Expert Opin. Investig. Drugs, 12(2), 185-195 (2003)
  175. Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
    Diastereoselective Synthesis of New ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics.
    J. Org. Chem., 67(17), 6162-6173 (2002)
  176. Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, Yoshihiko Odagaki, Shinya Oishi, Hirokazu Tamamura, Nobuyuki Hamanaka & Nobutaka Fujii
    Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2′ Reactions.
    J. Org. Chem., 67(17), 6152-6161 (2002)
  177. Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii
    Regio- and Stereoselective Ring-opening of Chiral 1,3-Oxazolidin-2-one Derivatives by Organocopper Reagents Provides Novel Access to Di-, tri- and tetra-substituted Alkene Dipeptide Isosteres.
    J. Chem. Soc., Perkin Trans. 1, 2002(15), 1786-1793 (2002)
  178. Akira Otaka, Miki Nakamura, Daisuke Nameki, Eiichi Kodama, Susumu Uchiyama, Syota Nakamura, Hiroaki Nakano, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka & Nobutaka Fujii
    Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells.
    Angew. Chem. Int. Ed., 41(16), 2937-2940 (2002)
  179. Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka & Nobutaka Fujii
    Diastereoselective Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-Type Dipeptide Isosteres Based on Organocopper-Mediated anti-SN2′ Reaction.
    Org. Lett., 4(7), 1055-1058 (2002)
  180. Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka & Nobutaka Fujii
    Diastereoselective Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-Type Dipeptide Isosteres by Organocopper-Mediated anti-SN2′ Reaction.
    Org. Lett., 4(7), 1051-1054 (2002)
  181. Wen-bo Zhang, Jean-Marc Navenot, Bodduluri Haribabu, Hirokazu Tamamura, Kenichi Hiramatsu, Akane Omagari, Gang Pei, Jhon P. Manfredi, Nobutaka Fujii, James R. Broach & Stephen C. Peiper
    A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals T140 is an Inverse Agonist and AMD3100 and ALX40-4C Are Weak Partial Agonists.
    J. Biol. Chem., 277(27), 24515-24521 (2002)
  182. Hirokazu Tamamura, Kenichi Hiramatsu, Kazuhide Miyamoto, Akane Omagari, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Yoshihiro Kuroda, Terumichi Nakagawa, Akira Otaka & Nobutaka Fujii
    Synthesis and Evaluation of Pseudopeptide Analogs of a Specific CXCR4 Inhibitor, T140: The Insertion of an (E)-Alkene Dipeptide Isostere into the βII’-Turn Moiety.
    Bioorg. Med. Chem. Lett., 12(6), 923-928 (2002)
  183. Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Shinya Oishi, Hiromu Habashita, Taisei Kanamoto, Kazuyo Gotoh, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Certification of the Critical Importance of L-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study.
    Bioorg. Med. Chem., 10(5), 1417-1426 (2002)
  184. Hirokazu Tamamura, Tadakazu Hori, Akira Otaka & Nobutaka Fujii
    Efficient Stereoselective Synthesis of Peptidomimetics Containing Hydroxyethylamine Dipeptide Isosteres Utilizing the Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions.
    J. Chem. Soc., Perkin Trans. 1, 2002(5), 577-580 (2002)
  185. Hirokazu Tamamura
    Development of Selective Antagonists against an HIV Second Receptor.
    YAKUGAKU ZASSHI, 121(11), 781-792 (2001)
  186. Nobutaka Fujii & Hirokazu Tamamura
    Peptide-lead CXCR4 Antagonists with High Anti-HIV Activity.
    Curr. Opin. Invest. Drugs, 2(9), 1198-1202 (2001)
  187. Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka & Nobutaka Fujii
    Stereoselective Synthesis of a Set of Two Functionalized (E)-Alkene Dipeptide Isosteres of L-Amino Acid-L-Glu and L-Amino acid-D-Glu.
    J. Chem. Soc., Perkin Trans. 1, 2001(19), 2445-2451 (2001)
  188. Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii
    New Access to α-Substituted (Z)-Fluoroalkene Dipeptide Isosteres Utilizing Organocopper Reagents under ‘Reduction-oxidative Alkylation (R-OA)’ Conditions.
    Tetrahedron Lett., 42(2), 5443-5446 (2001)
  189. Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Taisei Kanamoto, Kazuyo Gotoh, Kenji Kanbara, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Synthesis and Evaluation of Bifunctional Anti-HIV Agents Based on Specific CXCR4 Antagonists-AZT Conjugation.
    Bioorg. Med. Chem., 9(8), 2179-2187 (2001)
  190. Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Kazuyo Gotoh, Taisei Kanamoto, Younong Xu, Eiichi Kodama, Masao Matsuoka, Toshio Hattori, Naoki Yamamoto, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Development of Specific CXCR4 Inhibitors Possessing High Selectivity Indexes as Well as Complete Stability in Serum Based on an Anti-HIV Peptide T140.
    Bioorg. Med. Chem. Lett., 11(14), 1897-1902 (2001)
  191. Kenji Kanbara, Setsuko Sato, Jun-ichi Tanuma, Hirokazu Tamamura, Kazuyo Gotoh, Manabu Yoshimori, Taisei Kanamoto, Motoo Kitano, Nobutaka Fujii & Hideki Nakashima
    Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134.
    AIDS Res. Hum. Retroviruses, 17(7), 615-622 (2001)
  192. Kazuyo Gotoh, Manabu Yoshimori, Kenji Kanbara, Hirokazu Tamamura, Taisei Kanamoto, Katsura Mochizuki, Nobutaka Fujii & Hideki Nakashima
    Increase of R5 HIV-1 Infection and CCR5 Expression in T cells Treated with High Concentrations of CXCR4 Antagonists and SDF-1.
    J. Infect. Chemother., 7, 28-36 (2001)
  193. Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Nobuyuki Hamanaka, Akira Otaka & Nobutaka Fujii
    Conformational Study of a Highly Specific CXCR4 Inhibitor, T140,Disclosing the Close Proximity of Its Intrinsic Pharmacophores Associated with Strong Anti-HIV Activity.
    Bioorg. Med. Chem. Lett., 11(3), 359-362 (2001)
  194. Akira Otaka, Hideaki Watanabe, Etsuko Mitsuyama, Akira Yukimasa, Hirokazu Tamamura & Nobutaka Fujii
    Synthesis of (Z)-Fluoroalkene Dipeptide Isosteres Utilizing Organocopper-Mediated Reduction of γ,γ-Difluoro-α,β-enoates.
    Tetrahedron Lett., 42 (2), 285-287 (2001)
  195. Hirokazu Tamamura, Akane Omagari, Shinya Oishi, Taisei Kanamoto, Naoki Yamamoto, Stephen C. Peiper, Hideki Nakashima, Akira Otaka & Nobutaka Fujii
    Pharmacophore Identification of a Specific CXCR4 Inhibitor, T140, Leads to Development of Effective Anti-HIV Agents with Very High Selectivity Indexes.
    Bioorg. Med. Chem. Lett., 10(23), 2633-2637 (2000)
  196. Keiko Udaka, Karl-Heinz Wiesmuller, Stefan Kienle, Gunther Jung, Hirokazu Tamamura, Hideo Yamagishi, Ko Okumura, Peter Walden, Taku Suto & Toshisuke Kawasaki
    An Automated Prediction of MHC Class 1-Binding Peptides Based on Positional Scanning with Peptide Libraties.
    Immunogenetics, 51(10), 816-828 (2000)
  197. Akira Otaka, Etsuko Mitsuyama, Takayoshi Kinoshita, Hirokazu Tamamura & Nobutaka Fujii
    Stereoselective Synthesis of CF2-Substituted Phosphothreonine Mimetics and Their Incorporation into Peptides Using Newly Developed Deprotection Procedure.
    J. Org. Chem., 65, 4888-4899 (2000)
  198. Hirokazu Tamamura, Bruno Bienfait, Kassoum Nacro, Nancy E. Lewin, Peter M. Blumberg & Victor E. Marquez
    Conformationally Constrained Analogues of Diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG Lactones in Binding to Protein Kinase C.
    J. Med. Chem., 43, 3209-3217 (2000)
  199. Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura & Nobutaka Fujii
    A New Practical Strategy for the Synthesis of Long-Chain Phosphopeptide.
    Chem. Pharm. Bull., 48(8), 1230-1233 (2000)
  200. Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura & Nobutaka Fujii
    Development of New Methodology for the Synthesis of Functionalized -Fluorophosphonates and Its Practical Application to the Preparation of Phosphopeptide Mimetics.
    Chem. Commun. , 2000, 1081-1082 (2000)
  201. Kiyokazu Kakugawa, Keiko Udaka, Kosuke Nakashima, Kayo Inaba, Yoshihiro Oka, Haruo Sugiyama, Hirokazu Tamamura & Hideo Yamagishi
    Efficient Induction of Peptide-Specific Cytotoxic T Lymphocytes by LPS-Activated Spleen Cells.
    Microbiol. Immunol., 44(2), 123-133 (2000)
  202. Tutomu Murakami, Tian-Yuan Zhang, Yoshio Koyanagi, Yuetsu Tanaka, Jin Kim, Yoichi Suzuki, Shigeru Minoguchi, Hirokazu Tamamura, Michinori Waki, Akiyoshi Matsumoto, Nobutaka Fujii, Hisatoshi Shida, James A. Hoxie, Stephen C. Peiper & Naoki Yamamoto
    Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection.
    J. Virol., 73(9), 7489-7496 (1999)
  203. Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka & Nobutaka Fujii
    Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing , -Unsaturated Ester Groups.
    J. Chem. Soc., Perkin Trans. 1, 1999, 2983-2996 (1999)
  204. Younong Xu, Hirokazu Tamamura, Rieko Arakaki, Hideki Nakashima, Xiaoyan Zhang, Nobutaka Fujii, Takashi Uchiyama & Toshio Hattori
    Marked Increase in Anti-HIV Activity, as Well as Inhibitory Activity against HIV Entry Mediated by CXCR4, Linked to Enhancement of the Binding Ability of Tachyplesin Analogs to CXCR4.
    AIDS Res. Hum. Retroviruses, 15(5), 419-427 (1999)
  205. Rieko Arakaki, Hirokazu Tamamura, Mariappan Premanathan, Kenji Kanbara, Sivasundaram Ramanan, Katsura Mochizuki, Masanori Baba, Nobutaka Fujii & Hideki Nakashima
    T134, a Small Molecule CXCR4 Inhibitor, Has No Cross Drug-Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure.
    J. Virol., 73(2), 1719-1723 (1999)
  206. Hirokazu Tamamura, Younong Xu, Toshio Hattori, Xiaoyan Zhang, Rieko Arakaki, Kenji Kanbara, Akane Omagari, Akira Otaka, Toshiro Ibuka, Naoki Yamamoto, Hideki Nakashima & Nobutaka Fujii
    A Low Molecular Weight Inhibitor against the Chemokine Receptor CXCR4: a Strong Anti-HIV Peptide T140.
    Biochem. Biophys. Res. Commun., 253(3), 877-882 (1998)
  207. Hiroaki Ohno, Kiyonori Ishii, Asami Honda, Hirokazu Tamamura, Nobutaka Fujii, Yoshiji Takemoto & Toshiro Ibuka
    A 2,3-cis-Selective Synthesis of Aziridines Bearing a Vinyl Group from Allyl Methyl Carbonates and Allyl Mesylates.
    J. Chem. Soc., Perkin Trans. 1, 1998(22), 3703-3716 (1998)
  208. Hirohide Uenishi, Norimasa Iwanami, Hideo Yamagishi, Takako Nakatani, Toshisuke Kawasaki, Hirokazu Tamamura, Nobutaka Fujii & Kagemasa Kuribayashi
    Induction of Crossreactivity in Endogenous Viral Peptide Non-reactive to FBL-3 Tumor-specific Helper T-Cell Clones.
    Microbiol. Immunol., 42(7), 479-484 (1998)
  209. Toshio Hattori, Haruko Komoda, Savita Pahwa, Masaki Tateyama, Xiaoyan Zhang, Younong Xu, Shigeru Oguma, Hirokazu Tamamura, Nobutaka Fujii, Katuyuki Fukutake & Takashi Uchiyama
    Decline of Anti-DP107 Antibody Associated with Clinical Progression.
    AIDS, 12(12), 1557-1559 (1998)
  210. Hirohide Uenishi, Norimasa Iwanami, Kagemasa Kuribayashi, Hirokazu Tamamura, Nobutaka Fujii, Takako Nakatani, Toshisuke Kawasaki & Hideo Yamagishi
    Overlapping Epitopes of Friend Murine Leukemia Virus gag-Encoded Leader Sequence Recognized by Single Cytotoxic T-Lymphocyte Clones.
    Immunology Lett., 62, 33-38 (1998)
  211. Hirokazu Tamamura, Makoto Imai, Tsunehito Ishihara, Masao Masuda, Hanae Funakoshi, Hiromi Oyake, Tsutomu Murakami, Rieko Arakaki, Hideki Nakashima, Akira Otaka, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Pharmacophore Identification of a Chemokine Receptor (CXCR4) Antagonist, T22 ([Tyr5,12, Lys7]-Polyphemusin II), witch Specifically Blocks T Cell Line-Tropic HIV-1 Infection.
    Bioorg. Med. Chem., 6(7), 1033-1041 (1998)
  212. Hirokazu Tamamura, Michinori Waki, Makoto Imai, Akira Otaka, Toshiro Ibuka, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Tsutomu Murakami, Hideki Nakashima, Naoki Yamamoto & Nobutaka Fujii
    Downsizing of an HIV-Cell Fusion Inhibitor, T22 ([Tyr5,12, Lys7]-Polyphemusin II), with the Maintenance of Anti-HIV Activity and Solution Structure.
    Bioorg. Med. Chem., 6(4), 473-479 (1998)
  213. Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Convenient One-pot Synthesis of Cystine-Containing Peptides Using the Trimethylsilyl Chloride-Dimethylsulfoxide/Trifluoroacetic Acid System and its Application to the Synthesis of Bifunctional Anti-HIV Compounds.
    J. Chem. Soc., Perkin Trans. 1, 1998(3), 495-500 (1998)
  214. Hirokazu Tamamura, Rieko Arakaki, Hanae Funakoshi, Makoto Imai, Akira Otaka, Toshiro Ibuka, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Effective Lowly Cytotoxic Analogs of an HIV-Cell Fuion Inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II).
    Bioorg. Med. Chem., 6(2), 231-238 (1998)
  215. Hirokazu Tamamura, Fumihiro Matsumoto, Kyoko Sakano, Akira Otaka, Toshiro Ibuka & Nobutaka Fujii
    Unambiguous Synthesis of Stromal Cell-Derived Factor-1 by Regioselective Disulfide Bond Formation Using a DMSO-Aqueous HCl System.
    Chem. Commun., 1998(1), 151-152 (1998)
  216. Hiromu Habashita, Takeshi Kawasaki, Masako Akaji, Hirokazu Tamamura, Tetsutaro Kimachi, Nobutaka Fujii & Toshiro Ibuka
    One-Pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols.
    Tetrahedron Lett., 38(48), 8307-8310 (1997)
  217. Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii & Toshiro Ibuka
    Regio- and Stereoselectivity in Reactions of 2,3-cis– and trans-3-Alkyl-2-vinylaziridines with Organocopper Reagents: Importance of 2,3-cis-Stereochemistry in Controlling Selectivity.
    Tetrahedron Lett., 38(42), 7383-7386 (1997)
  218. Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Hiroaki Ohno, Toshiro Ibuka, Akira Otaka & Nobutaka Fujii
    Regiospecific Ring-Opening Reactions of Aziridines Bearing an α,β-Unsaturated Ester Group with Trifluoroacetic Acid or Methanesulfonic Acid: Application to the Stereoselective Synthesis of (E)-Alkene Dipeptide Isosteres.
    Chem. Commun., 1997, 2327-2328 (1997)
  219. Tsutomu Murakami, Toshihiro Nakajima, Yoshio Koyanagi, Kazunobu Tachibana, Nobutaka Fujii, Hirokazu Tamamura, Nobuaki Yoshida, Michinori Waki, Akiyoshi Matsumoto, Osamu Yoshie, Tadamitsu Kishimoto, Naoki Yamamoto & Takashi Nagasawa
    A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line-tropic HIV-1 Infection.
    J. Exp. Med., 186(8), 1389-1393 (1997)
  220. Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake & Yoshinori Yamamoto
    Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α,β-Unsaturated Ester Group.
    Tetrahedron, 53(38), 12933-12946 (1997)
  221. Toshiro Ibuka, Norio Mimura, Hiroaki Ohno, Kazuo Nakai, Masako Akaji, Hiromu Habashita, Hirokazu Tamamura, Yoshihisa Miwa, Tooru Taga, Nobutaka Fujii & Yoshinori Yamamoto
    Palladium(o)-Catalyzed Isomerization Reactions of Aziridines Bearing an α,β-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers.
    J. Org. Chem., 62(9), 2982-2991 (1997)
  222. Toshiro Ibuka, Norio Mimura, Hiroshi Aoyama, Masako Akaji, Hiroaki Ohno, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto
    A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-vinylaziridines over Their 2,3-trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosters.
    J. Org. Chem., 62(4), 999-1015 (1997)
  223. Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Kyoko Sakano, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    An Anti-HIV Peptide, T22, Forms a Highly Active Complex with Zn(II).
    Biochem. Biophys. Res. Commun., 229, 648-652 (1996)
  224. Toshiro Ibuka, Kazuo Nakai, Masako Akaji, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto
    An Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols in a One-pot Manner: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure N-Protected 1,2-Amino Alcohols.
    Tetrahedron, 52, 11739-11752 (1996)
  225. Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Analysis of the Interaction of an Anti-HIV Peptide, T22 ([Tyr5,12, Lys7]-Polyphemusin II), with Gp120 and CD4 by Surface Plasmon Resonance.
    Biochim. Biophys. Acta, 1298, 37-44 (1996)
  226. Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka & Nobutaka Fujii
    A Convenient One-pot Synthesis of Cystine-Containing Peptides from Protected Peptidyl Resins Using the Trimethylsilyl Chloride-Dimethylsulfoxide-Trifluoroacetic Acid System.
    J. Chem. Soc., Perkin Trans. 1 (Perkin Commun.), 1996, 1911-1912 (1996)
  227. Michinori Waki, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Hirokazu Tamamura, Nobutaka Fujii, Tsutomu Murakami, Hideki Nakashima & Naoki Yamamoto
    Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity.
    Chem. Lett., 1996, 571-572 (1996)
  228. Nobutaka Fujii, Hiromu Habashita, Masako Akaji, Kazuo Nakai, Toshiro Ibuka, Masahiro Fujiwara, Hirokazu Tamamura & Yoshinori Yamamoto
    A Simple One-pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols.
    J. Chem. Soc., Perkin Trans. 1 (Perkin Commun.), 1996, 865-866 (1996)
  229. Toshiro Ibuka, Masako Akaji, Norio Mimura, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto
    A Thermodynamic Preference of Chiral cis-γ,δ-Epimino-(E)-α,β-Unsaturated Esters over Other Stereoisomers: Synthetically Useful Pd(0)-Catalyzed Equilibrated Reactions of Aziridines Bearing an α,β-Unsaturated Ester Groups.
    Tetrahedron Lett., 37, 2849-2852 (1996)
  230. Norio Mimura, Toshiro Ibuka, Masako Akaji, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto
    An Unusual Thermodynamic Preference of Chiral N-Arylsulfonyl cis-3-Alkyl-2-vinylaziridines over Theirtrans-Isomers: Palladium(0)-Catalyzed Equilibration Reaction.
    J. Chem. Soc., Chem. Commun., 1996, 351-352 (1996)
  231. Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Tsunehito Ishihara, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Interaction of an Anti-HIV Peptide, T22, with Gp120 and CD4.
    Biochem. Biophys. Res. Commun., 219, 555-559 (1996)
  232. Tokukazu Kondo, Hirohide Uenishi, Takeyuki Shimizu, Toshiyasu Hirama, Michihiro Iwashiro, Kagemasa Kuribayashi, Hirokazu Tamamura, Nobutaka Fujii, Ryuichi Fujisawa, Masaaki Miyazawa & Hideo Yamagishi
    A Signal Retroviral Gag Precursor Signal Peptide Recognized by FBL-3 Tumor-Specific Cytotoxic T Lymphocytes.
    J. Virol., 69, 6735-6741 (1995)
  233. Benjamin S. Weeks, Motoyoshi Nomizu, Akira Otaka, Christi A. Weston, Akiko Okusu, Hirokazu Tamamura, Naoki Yamamoto & Nobutaka Fujii
    The Synthetic [Tyr5,12, Lys7]-Polyphemusin II Peptide (T22) Binds to the CD4 Cell Surface Molecule.
    Biochem. Biophys. Res. Commun., 215, 626-631 (1995)
  234. Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto
    A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alcohols.
    Tetrahedron Lett., 36, 6247-6250 (1995)
  235. Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke, Jr. & Peter P. Roller
    Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides.
    J. Org. Chem., 60, 3967-3974 (1995)
  236. Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto & Toshiro Ibuka
    SN2′ Ring Opening of Aziridines Bearing an α,β-Unsaturated Ester Group with Organocopper Reagents. A New Stereoselective Synthesis Route to (E)-Alkene Dipeptide Isosters.
    J. Chem. Soc., Perkin Trans. 1, 1995, 1359-1371 (1995)
  237. Hirokazu Tamamura, Tsutomu Murakami, Sankichi Horiuchi, Keiji Sugihara, Akira Otaka, Wataru Takada, Toshiro Ibuka, Michinori Waki, Naoki Yamamoto & Nobutaka Fujii
    Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-Human Immunodeficiency Virus Activity.
    Chem. Pharm. Bull., 43, 853-858 (1995)
  238. Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan & Yoshinori Yamamoto
    Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions.
    J. Org. Chem., 60, 2044-2058 (1995)
  239. Hirokazu Tamamura, Akira Otaka, Junko Nakamura, Kaori Okubo, Takaki Koide, Kyoko Ikeda, Toshiro Ibuka & Nobutaka Fujii
    Disulfide Bond-Forming Reaction using a Dimethyl Sulfoxide / Aqueous HCl System and Its Application to Regioselective Two Disulfide Bond Formation.
    Int. J. Peptide Protein Res., 45, 312-319 (1995)
  240. Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke, Jr., Hirokazu Tamamura & Nobutaka Fujii
    Practical Synthesis of Phosphopeptides using Dimethyl-protected Phosphoamino Acid Derivatives.
    J. Chem. Soc., Chem. Commun., 1995, 387-389 (1995)
  241. Akira Otaka, Kengo Miyoshi, Terrence R. Burke, Jr., Peter P. Roller, Hideki Kubota, Hirokazu Tamamura & Nobutaka Fujii
    Synthesis and Application of N-Boc-L-2-amino-4-(diethylphosphono)-4, 4-difluorobutanoic acid for Solid-Phase Synthesis of Nonhydrolyzable Phosphoserine Peptide Analogs.
    Tetrahedron Lett., 36, 927-930 (1995)
  242. Hirokazu Tamamura, Akira Otaka, Wataru Takada, Yoshihiro Terakawa, Hidenori Yoshizawa, Masao Masuda, Toshiro Ibuka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Solution-Phase Synthesis of an Anti-Human Immunodeficiency Virus Peptide, T22 ([Tyr5,12, Lys7]-Polyphemusin II), and the Modification of Trp by the p-Methoxybenzyl Group of Cys during Trimethylsilyl Trifluoromethanesulfonate Deprotection.
    Chem. Pharm. Bull., 43, 12-18 (1995)
  243. Takeyuki Shimizu, Hirohide Uenishi, Yasufumi Teramura, Michihiro Iwashiro, Kagemasa Kuribayashi, Hirokazu Tamamura, Nobutaka Fujii & Hideo Yamagishi
    Fine Structure of a Virus-Encoded Helper T-Cell Epitope Expressed on FBL-3 Tumor Cells.
    J. Virol., 68, 7704-7708 (1994)
  244. Hirokazu Tamamura, Tsutomu Murakami, Masao Masuda, Akira Otaka, Wataru Takada, Toshiro Ibuka, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Structure-Activity Relationships of an Anti-HIV Peptide, T22.
    Biochem. Biophys. Res. Commun., 205, 1729-1735 (1994)
  245. Akira Otaka, Hirokazu Tamamura, Yoshihiro Terakawa, Masao Masuda, Takaki Koide, Tsutomu Murakami, Hideki Nakashima, Katsumi Matsuzaki, Koichiro Miyajima, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Molecular Parameters for the Anti-Human Immunodeficiency Virus Activity of T22 ([Tyr5,12, Lys7]-Polyphemusin II).
    Biol. Pharm. Bull., 17, 1669-1672 (1994)
  246. Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Hirokazu Tamamura, Akira Otaka & Toshiro Ibuka
    Synthesis of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks.
    Chem. Pharm. Bull., 42, 2241-2250 (1994)
  247. Toshiro Ibuka, Keisuke Suzuki, Hiromu Habashita, Akira Otaka, Hirokazu Tamamura, Norio Mimura, Yoshihisa Miwa, Tooru Taga & Nobutaka Fujii
    (E)-Stereoselective Synthesis of Vinylglycines from (R)-Serine via Organocopper-BF3 and Related Reagents.
    J. Chem. Soc., Chem. Commun., 1994, 2151-2152 (1994)
  248. Benjamin S. Weeks, Motoyoshi Nomizu, Akira Otaka, Christi A. Weston, Akiko Okusu, Hirokazu Tamamura, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii
    Lymphocytes and Promonocytes Attach to the Synthetic [Tyr5,12, Lys7]-Polyphemusin II Peptide.
    Biochem. Biophys. Res. Commun., 202, 470-475 (1994)
  249. Hirokazu Tamamura, Akira Otaka, Junko Nakamura, Kaori Okubo, Takaki Koide, Kyoko Ikeda & Nobutaka Fujii
    Disulfide Bond Formation in S-Acetamidomethyl Cysteine-Containing Peptides by the Combination of Silver Trifluoromethanesulfonate and Dimethylsulfoxide / Aqueous HCl.
    Tetrahedron Lett., 34, 4931-4934 (1993)
  250. Hirokazu Tamamura, Masataka Kuroda, Masao Masuda, Akira Otaka, Susumu Funakoshi, Hideki Nakashima, Naoki Yamamoto, Michinori Waki, Akiyoshi Matsumoto, Jean M. Lancelin, Daisuke Kohda, Shinichi Tate, Fuyuhiko Inagaki & Nobutaka Fujii
    A Comparative Study of the Solution Structures of Tachyplesin I and a Novel Anti-HIV Synthetic Peptide, T22 ([Tyr5,12, Lys7]-Polyphemusin II), Determined by Nuclear Magnetic Resonance.
    Biochim. Biophys. Acta, 1163, 209-216 (1993)
  251. Hirokazu Tamamura, Rie Ikoma, Makoto Niwa, Susumu Funakoshi, Tsukasa Murakami & Nobutaka Fujii
    Antimicrobial Activity and Conformation of Tachyplesin I and Its Analogs.
    Chem. Pharm. Bull., 41, 978-980 (1993)
  252. Hirokazu Tamamura, Junko Nakamura, Katsuhiro Noguchi, Susumu Funakoshi & Nobutaka Fujii
    Acceleration of Nα-Deprotection Rate by the Addition of m-Cresol to Diluted Methanesulfonic Acid and Its Application to the Z(OMe)-Based Solid-Phase Syntheses of Human Pancreastatin-29 and Magainin 1.
    Chem. Pharm. Bull., 41, 954-957 (1993)
  253. Toshiro Ibuka, Tooru Taga, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii, Yukiyasu Chounan, Hisao Nemoto & Yoshinori Yamamoto
    Syn-SN2′ Pathway in the Reaction of Certain γ-(Mesyloxy)-α,β-Enoates with RCu(CN)MgX.BF3Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity.
    J. Org. Chem., 58, 1207-1214 (1993)
  254. Masao Masuda, Hideki Nakashima, Toshihiro Ueda, Hiroyasu Naba, Rie Ikoma, Akira Otaka, Yoshihiro Terakawa, Hirokazu Tamamura, Toshiro Ibuka, Tsutomu Murakami, Yoshio Koyanagi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto, Susumu Funakoshi & Nobutaka Fujii
    A Novel Anti-HIV Synthetic Peptide, T-22 ([Tyr5,12, Lys7]-Polyphemusin II).
    Biochem. Biophys. Res. Commun., 189, 845-850 (1992)
  255. Akihiro Funakoshi, Kyoko Miyasaka, Kenichi Kitani, Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Itsuro Nakano & Kazuhiko Tatemoto
    Comparative Effects of Mammalian Pancreastatin on the Pancreatic Exocrine Secretion.
    Japanese J. Pysiol., 39, 901-905 (1990)
  256. Kyoko Miyasaka, Akihiro Funakoshi, Yohichi Yasunami, Rieko Nakamura, Kenichi Kitani, Hirokazu Tamamura, Susumu Funakoshi & Nobutaka Fujii
    Rat Pancreastatin Inhibits Both Pancreatic Exocrine and Endocrine Secretions in Rats.
    Regulatory Peptides, 28, 189-198 (1990)
  257. Kyoko Miyasaka, Akihiro Funakoshi, Kenichi Kitani, Hirokazu Tamamura, Susumu Funakoshi & Nobutaka Fujii
    Inhibitory Effect of Pancreastatin on Pancreatic Exocrine Secretion. Pancreastatin Inhibits Central Vagel Nerve Stimulation.
    Gastroenterology, 99, 1751-1756 (1990)
  258. Hirokazu Tamamura, Mitsuhiro Ohta, Kumi Yoshizawa, Yoshiyuki Ono, Akihiro Funakoshi, Kyoko Miyasaka, Kayoko Tateishi, Atsuo Jimi, Haruaki Yajima, Nobutaka Fujii & Susumu Funakoshi
    Isolation and Characterization of a Tumor-Derived Human Protein Related to Chromogranin A and Its in Vitro Conversion to Human Pancreastatin-48.
    Eur. J. Biochem., 191, 33-39 (1990)
  259. Kyoko Miyasaka, Akihiro Funakoshi, Kenichi Kitani, Hirokazu Tamamura, Nobutaka Fujii & Susumu Funakoshi
    The Importance of the C-Terminal Amide Structure of Rat Pancreastatin to Inhibit Pancreatic Exocrine Secretion.
    FEBS Lett., 263, 279-280 (1990)
  260. Kayoko Tateishi, Akihiro Funakoshi, Hideyuki Wakasugi, Haruo Iguchi, Hirotsugu Shinozaki, Muneaki Abe, Susumu Funakoshi, Hirokazu Tamamura, Haruaki Yajima & Yuji Matsuoka
    Plasma Pancreastatin-Like Immunoreactivity in Various Diseases.
    J. Clin. Endocrin. and Metabo., 69, 1305-1308 (1989)
  261. Susumu Funakoshi, Hirokazu Tamamura, Mitsuhiro Ohta, Kumi Yoshizawa, Akihiro Funakoshi, Kyoko Miyasaka, Kayoko Tateishi, Kazuhiko Tatemoto, Itsuro Nakano, Haruaki Yajima & Nobutaka Fujii
    Isolation and Characterization of a Tumor-Derived Human Pancreastatin-Related Protein.
    Biochem. Biophys. Res. Commun., 164, 141-148 (1989)
  262. Akihiro Funakoshi, Atsuo Jimi, Yohichi Yasunami, Kayoko Tateishi, Susumu Funakoshi, Hirokazu Tamamura & Haruaki Yajima
    Bioactivity of Human Pancreastatin and Its Localization of Pancreas.
    Biochem. Biophys. Res. Commun., 159, 913-918 (1989)
  263. Akihiro Funakoshi, Kyoko Miyasaka, Kenichi Kitani, Hirokazu Tamamura, Susumu Funakoshi & Haruaki Yajima
    Bioactivity of Synthetic C-Terminal Fragment of Rat Pancreastatin on Endocrine Pancreas.
    Biochem. Biophys. Res. Commun., 158, 844-849 (1989)
  264. Kayoko Tateishi, Akihiro Funakoshi, Atsuo Jimi, Susumu Funakoshi, Hirokazu Tamamura, Haruaki Yajima & Yuji Matsuoka
    High Plasma Pancreastatinlike Immunoreactivity in a Patient with Malignant Insulinoma.
    Gastroenterology, 97, 1313-1318 (1989)
  265. Nobutaka Fujii, Akira Otaka, Toshihiro Watanabe, Akira Okamachi, Hirokazu Tamamura, Haruaki Yajima, Yoshimasa Inagaki, Motoyoshi Nomizu & Katsuhiko Asano
    Silver Trifluoromethanesulphonate as an S-Deprotecting Reagent for the Synthesis of Cystine Peptides.
    J. Chem. Soc., Chem. Commun., 1989, 283-284 (1989)
  266. Akihiro Funakoshi, Kyoko Miyasaka, Rieko Nakamura, Kenichi Kitani, Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii & Haruaki Yajima
    Bioactivity of Synthetic Human Pancreastatin on Exocrine Pancreas.
    Biochem. Biophys. Res. Commun., 156, 1237-1242 (1988)
  267. Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Kumi Yoshizawa, Haruaki Yajima, Kyoko Miyasaka, Akihiro Funakoshi, Mitsuhiro Ohta, Yoshimasa Inagaki & Louis A. Carpino
    Combination of a New Amide-precursor Reagent and Trimethylsilyl Bromide Deprotection for the Fmoc-based Solid Phase Synthesis of Human Pancreastatin and One of its Fragment.
    J. Chem. Soc., Chem. Commun., 1988, 1588-1590 (1988)

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